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Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model

Autor: Bebarta, VS, Garrett, N, Brenner, M, Mahon, SB, Maddry, JK, Boudreau, S, Castaneda, M, Boss, GR

Publikováno v: Bebarta, VS; Garrett, N; Brenner, M; Mahon, SB; Maddry, JK; Boudreau, S; et al.(2017). Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model. ACADEMIC EMERGENCY MEDICINE, 24(9), 1088-1098. doi: 10.1111/acem.13213. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1tc2m19p

Hydrogen sulfide (H2 S) is a potentially deadly gas that naturally occurs in petroleum and natural gas. The Occupational Health and Safety Administration cites H2 S as a leading cause of workplace gas inhalation deaths. Mass casualties of H2 S toxici

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http://www.escholarship.org/uc/item/1tc2m19p

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Cisplatin Analogs Confer Protection against Cyanide Poisoning

Autor: Nath, AK, Shi, X, Harrison, DL, Morningstar, JE, Mahon, S, Chan, A, Sips, P, Lee, J, MacRae, CA, Boss, GR, Brenner, M, Gerszten, RE, Peterson, RT

Publikováno v: Nath, AK; Shi, X; Harrison, DL; Morningstar, JE; Mahon, S; Chan, A; et al.(2017). Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chemical Biology, 24(5), 565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0zp0p6zf

© 2017 Elsevier Ltd Cisplatin holds an illustrious position in the history of chemistry most notably for its role in the virtual cure of testicular cancer. Here we describe a role for this small molecule in cyanide detoxification in vivo. Cyanide ki

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http://www.escholarship.org/uc/item/0zp0p6zf

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Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote

Autor: Jiang, J, Chan, A, Ali, S, Saha, A, Haushalter, KJ, Lam, WLMR, Glasheen, M, Parker, J, Brenner, M, Mahon, SB, Patel, HH, Ambasudhan, R, Lipton, SA, Pilz, RB, Boss, GR

Publikováno v: Scientific reports, vol 6, iss 1
Jiang, J; Chan, A; Ali, S; Saha, A; Haushalter, KJ; Lam, WLMR; et al.(2016). Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote. Scientific Reports, 6. doi: 10.1038/srep20831. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9k95f0s4

Hydrogen sulfide is a highly toxic gas-second only to carbon monoxide as a cause of inhalational deaths. Its mechanism of toxicity is only partially known, and no specific therapy exists for sulfide poisoning. We show in several cell types, including

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https://escholarship.org/uc/item/9k95f0s4

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Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy

Autor: Lee, J, Kim, JG, Mahon, SB, Mukai, D, Yoon, D, Boss, GR, Patterson, SE, Rockwood, G, Isom, G, Brenner, M

Publikováno v: Lee, J; Kim, JG; Mahon, SB; Mukai, D; Yoon, D; Boss, GR; et al.(2014). Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy. Journal of Biomedical Optics, 19(5). doi: 10.1117/1.JBO.19.5.055001. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4qd236dc

A major need exists for methods to assess organ oxidative metabolic states in vivo. By contrasting the responses to cyanide (CN) poisoning versus hemorrhage in animal models, we demonstrate that diffuse optical spectroscopy (DOS) can detect cytochrom

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http://www.escholarship.org/uc/item/4qd236dc

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Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism

Autor: Kim, JG, Lee, J, Mahon, SB, Mukai, D, Patterson, SE, Boss, GR, Tromberg, BJ, Brenner, M

Publikováno v: Kim, JG; Lee, J; Mahon, SB; Mukai, D; Patterson, SE; Boss, GR; et al.(2012). Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism. Journal of Biomedical Optics, 17(10). doi: 10.1117/1.JBO.17.10.105005. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/869500gv

Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::4c5ee1d6f1e291e64ad7d08cd759217e
http://www.escholarship.org/uc/item/869500gv

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