Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Boshoff, Helena IM"'
Publikováno v:
In Current Opinion in Pharmacology October 2018 42:81-94
Autor:
Thomas, Sherine E, Whitehouse, Andrew J, Brown, Karen, Burbaud, Sophie, Belardinelli, Juan M, Sangen, Jasper, Lahiri, Ramanuj, Libardo, Mark Daben J, Gupta, Pooja, Malhotra, Sony, Boshoff, Helena IM, Jackson, Mary, Abell, Chris, Coyne, Anthony G, Blundell, Tom L, Floto, Rodrigo Andres, Mendes, Vítor
Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283d014d6acdc935d9392c6147b6c3dc
Autor:
Kasbekar, Monica, Fischer, Gerhard, Mott, Bryan T, Yasgar, Adam, Hyvönen, Marko, Boshoff, Helena IM, Abell, Chris, Barry, Clifton E, Thomas, Craig J
Enzymes in essential metabolic pathways are attractive targets for the treatment of bacterial diseases, but in many cases, the presence of homologous human enzymes makes them impractical candidates for drug development. Fumarate hydratase, an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241bef635b94afe0ae2d5712c457f457
Autor:
Whitehouse, Andrew J, Thomas, Sherine E, Brown, Karen P, Fanourakis, Alexander, Chan, Daniel S-H, Libardo, M Daben J, Mendes, Vitor, Boshoff, Helena IM, Floto, R Andres, Abell, Chris, Blundell, Tom L, Coyne, Anthony G
Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria that has emerged as a growing threat to individuals with cystic fibrosis and other pre-existing chronic lung diseases. Mab pulmonary infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65ced96ae0ee1ddeee07d598bd35b0a3
Autor:
Evans, Joanna C, Murugesan, Dinakaran, Post, John M, Mendes, Vitor, Wang, Zhe, Nahiyaan, Navid, Lynch, Sasha L, Thompson, Stephen, Green, Simon R, Ray, Peter C, Hess, Jeannine, Spry, Christina, Coyne, Anthony G, Abell, Chris, Boshoff, Helena IM, Wyatt, Paul G, Rhee, Kyu Y, Blundell, Tom L, Barry, Clifton E, Mizrahi, Valerie
Coenzyme A (CoA) is a ubiquitous cofactor present in all living cells and estimated to be required for up to 9% of intracellular enzymatic reactions. Mycobacterium tuberculosis (Mtb) relies on its own ability to biosynthesize CoA to meet the needs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f229c7104110e031d1f062c7673cbab
Autor:
Mendes, Vitor, Green, Simon R, Evans, Joanna C, Hess, Jeannine, Blaszczyk, Michal, Spry, Christina, Bryant, Owain, Cory-Wright, James, Chan, Daniel S-H, Torres, Pedro HM, Wang, Zhe, Nahiyaan, Navid, O'Neill, Sandra, Damerow, Sebastian, Post, John, Bayliss, Tracy, Lynch, Sasha L, Coyne, Anthony G, Ray, Peter C, Abell, Chris, Rhee, Kyu Y, Boshoff, Helena IM, Barry, Clifton E, Mizrahi, Valerie, Wyatt, Paul G, Blundell, Tom L
Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens including Mycobacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::764860a329724c072160131446005dec
Autor:
Paul G. Wyatt, Peter C. Ray, Kyu Y. Rhee, Sasha L. Lynch, Valerie Mizrahi, Clifton E. Barry, John Post, Helena I. Boshoff, Navid Nahiyaan, Anthony G. Coyne, Tom L. Blundell, Joanna C. Evans, Christina Spry, Dinakaran Murugesan, Vitor Mendes, Simon Green, Jeannine Hess, Stephen Thompson, Chris Abell, Zhe Wang
Publikováno v:
ACS Infectious Diseases
Coenzyme A (CoA) is a ubiquitous cofactor present in all living cells and estimated to be required for up to 9% of intracellular enzymatic reactions. Mycobacterium tuberculosis (Mtb) relies on its own ability to biosynthesize CoA to meet the needs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b118e20c165cc2ee3aa60e19f743440
https://www.repository.cam.ac.uk/handle/1810/322238
https://www.repository.cam.ac.uk/handle/1810/322238
Autor:
Clifton E. Barry, Paul G. Wyatt, Sasha L. Lynch, Pedro Henrique Monteiro Torres, Daniel Shiu-Hin Chan, Simon Green, Helena I. Boshoff, Joanna C. Evans, Vitor Mendes, Kyu Y. Rhee, James Cory-Wright, Michal Blaszczyk, Peter C. Ray, Valerie Mizrahi, Sebastian Damerow, Navid Nahiyaan, Anthony G. Coyne, John Post, Tom L. Blundell, Tracy Bayliss, Sandra O’Neill, Chris Abell, Jeannine Hess, Christina Spry, Zhe Wang, Owain J. Bryant
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens including Mycobacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93480516255c2e8d7aeba39be349059
http://europepmc.org/articles/PMC7794376
http://europepmc.org/articles/PMC7794376
Autor:
M. Daben J. Libardo, Monica Kasbekar, Helena I. Boshoff, Chris Abell, Craig J. Thomas, Clifton E. Barry, Paul Brear, Gerhard Fischer, Anthony G. Coyne, Andrew J. Whitehouse
With the growing worldwide prevalence of antibiotic-resistant strains of tuberculosis (TB), new targets are urgently required for the development of treatments with novel modes of action. Fumarate hydratase (fumarase), a vulnerable component of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2137f8a13f7a26d72652b5607976c34b
Autor:
Vitor Mendes, Alexander Fanourakis, Andrew J. Whitehouse, Daniel Shiu-Hin Chan, M. Daben J. Libardo, Sherine E. Thomas, Helena I. Boshoff, Karen Brown, Tom L. Blundell, Chris Abell, R. Andres Floto, Anthony G. Coyne
Publikováno v:
Journal of Medicinal Chemistry
Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria (NTM) that has emerged as a growing threat to individuals with cystic fibrosis, and other pre-existing chronic lung diseases. Mab pulmonary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52186c7af72fee73a2e1c29f1c70c7d2
https://doi.org/10.26434/chemrxiv.8131847.v1
https://doi.org/10.26434/chemrxiv.8131847.v1