Targeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer

Autor: Yunong Xie, Haofeng Wu, Yimiao He, Linglin Liu, Ianto Bosheng Huang, Lei Zhou, Cheuk-Yin Lin, Rainbow Wing-Hei Leung, Jia-Jian Loh, Terence Kin-Wah Lee, Jin Ding, Kwan Man, Stephanie Ma, Man Tong

Publikováno v: Cell Death and Disease, Vol 15, Iss 2, Pp 1-15 (2024)

Abstract Hepatocellular carcinoma (HCC) is an aggressive malignancy without effective therapeutic approaches. Here, we evaluate the tumor-intrinsic mechanisms that attenuate the efficacy of immune checkpoint inhibitor (ICI) that is observed in patien

Externí odkaz: https://doaj.org/article/d8315cac64644c18a3125b5147874cd7

Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches

Autor: Zengbing Lu, Yu Zhou, Longlong Tu, Sze Wa Chan, Man P. Ngan, Dexuan Cui, Yuen Hang Julia Liu, Ianto Bosheng Huang, Jeng S. C. Kung, Chung Man Jessica Hui, John A. Rudd

Publikováno v: Frontiers in Physiology, Vol 11 (2021)

Nausea and emesis resulting from disease or drug treatment may be associated with disrupted gastric myoelectric activity (GMA). Conventional analytical techniques can determine the relative degrees of brady-, normo-, and tachygastric power, but lose

Externí odkaz: https://doaj.org/article/1bd3840da96441499db880ff785da2bb

Abstract 395: Resistance to tyrosine kinase inhibitor confers an immunosuppressive microenvironment and cross-resistance to immunotherapy through AXL/PDPK1 axis in liver cancer

Autor: Yunong Xie, Bosheng Huang, Huajian Yu, Jia-Jian Loh, Rainbow Wing-Hei Leung, Terence Lee, Stephanie Ma, Man Tong

Publikováno v: Cancer Research. 83:395-395

Systemic therapy is the current standard of care for unresectable advanced hepatocellular carcinoma (HCC), the most malignant form of liver cancer. Clinical practice guideline for HCC includes the management of the second-line immunotherapies after p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70a99860422d74cbf6b4c9a10a333d60
https://doi.org/10.1158/1538-7445.am2023-395

Constitutive activation of AMPK α1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction

Autor: Yan Liang, Yu Wang, Bosheng Huang, Bo Bai, Erfei Song

Publikováno v: British Journal of Pharmacology. 171:498-508

Background and Purpose AMP-activated protein kinase (AMPK), an important regulator of energy metabolism, comprises three (α, β and γ) subunits, each with a unique tissue distribution. As AMPK has a wide range of protein and gene targets, defining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78071ceab795830e51c9a816af0cd866
https://doi.org/10.1111/bph.12482

Contents Vol. 90, 2012

Autor: Keisuke Ishizawa, Jung Sook Suh, Maria Frosini, Masaki Imanishi, Sarah J. Mitchell, Kai Kappert, Linyong Xu, Georg Dechant, Sui-Lin Mo, Heiko Funke-Kaiser, Piero Tanganelli, Koichiro Tsuchiya, M. Zeitlinger, Ludo Willems, Josef Donnerer, Jae-Wook Oh, Z. Erdogan, A. Burian, Ingrid Liebmann, Ignacio Valencia-Hernández, Bosheng Huang, Christian Humpel, Min-Ji Song, Constanze M. Barwitz, Licht Miyamoto, Giampietro Sgaragli, José Carlos Villegas-Bedolla, Hyung-Sik Kang, Tomoyuki Nishizaki, Alessandra Larini, Shu-Feng Zhou, Jin-Jun Zhang, Geert Meyfroidt, Kisung Ko, Kerstin Seidel, Daniel Godínez-Hernández, Hyun Soo Kwak, Lorenzo Ricci, Luisa Lucas, Victoria C. Cogger, Héctor Urquiza-Marín, Yasumasa Ikeda, Yoshitaka Kihira, Gerald Zernig, Shuhei Tomita, Shoko Fujii, Sarah N. Hilmer, Ming Wei, Haeng-A. Kang, Geert Maleux, Yuling Chen, Rafael de Cabo, Min Park, Beatrice Gorelli, Lai-Bao Sun, Kai K. Kummer, Takeshi Kanno, Xue-Nong Zou, Chris Verslype, Sarah Bernhard, Ki-Mo Lee, Blanca Nateras-Marín, José Antonio Reyes-Ramírez, Sabrina Klare, Toshiaki Tamaki, Akinobu Gotoh, Brett Jones, Janine M. Prast, Hwa-Youn Lee, Eva Schrezenmeier, Christian Böhm, Wan Kyunn Whang, Takumi Sakurada, Shuichi Hamano, Jong Mi Lee, Yuki Izawa-Ishizawa, Isabel Spriet, Aniko Huizer-Pajkos, Chung Hyo Kim, David G. Le Couteur, Massimo Valoti, Sebastian Kirsch, C. Jandrisits, Petra Goldin-Lang, Andrew J. McLachlan, Druck Reinhardt Druck Basel, Uy Dong Sohn, Thao Thanh Nguyen, Sun Young Park, Xian-Guo Liu, Lijun Cao, Neel R. Nabar, Melanie Kroh, Qiu-Lan He, Werner Skuballa, Hisao Nagaya, Frank S. Zollmann, Lixiang Wu, Hironori Taira, Thomas Unger, Kristin Schmerbach

Publikováno v: Pharmacology. 90:I-IV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f47e12278c97a01fd01afb1a24b16c0
https://doi.org/10.1159/000345034