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Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.

Autor: Tadros R; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Zheng SL; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Grace C; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Jordà P; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Francis C; National Heart & Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Jurgens SJ; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Thomson KL; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Oxford Genetics Laboratories, Churchill Hospital, Oxford, UK., Harper AR; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Ormondroyd E; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., West DM; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Xu X; MRC London Institute of Medical Sciences, Imperial College London, London, UK., Theotokis PI; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Buchan RJ; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., McGurk KA; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK., Mazzarotto F; National Heart & Lung Institute, Imperial College London, London, UK.; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Boschi B; Genetics Unit, Careggi University Hospital, Florence, Italy., Pelo E; Genetics Unit, Careggi University Hospital, Florence, Italy., Lee M; National Heart & Lung Institute, Imperial College London, London, UK., Noseda M; National Heart & Lung Institute, Imperial College London, London, UK., Varnava A; National Heart & Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Vermeer AM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Genetics, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, (ERN GUARD-HEART; https://guardheart.ern-net.eu)., Walsh R; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Amin AS; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, (ERN GUARD-HEART; https://guardheart.ern-net.eu).; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., van Slegtenhorst MA; Department of Clinical Genetics, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands., Roslin N; The Centre for Applied Genomics, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Strug LJ; Departments of Statistical Sciences and Computer Science, Data Sciences Institute, University of Toronto, Toronto, ON, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada.; Ontario Regional Centre, Canadian Statistical Sciences Institute, University of Toronto, Toronto, ON, Canada., Salvi E; Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Lanzani C; Genomics of Renal Diseases and Hypertension Unit, Nephrology Operative Unit, IRCCS San Raffaele Hospital, Milan, Italy.; Chair of Nephrology, Vita-Salute San Raffaele University, Milan, Italy., de Marvao A; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK., Roberts JD; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, ON, Canada., Tremblay-Gravel M; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Giraldeau G; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Cadrin-Tourigny J; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., L'Allier PL; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Garceau P; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Talajic M; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Pinto YM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, (ERN GUARD-HEART; https://guardheart.ern-net.eu).; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Rakowski H; Peter Munk Cardiac Centre, Toronto, ON, Canada., Pantazis A; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Baksi J; National Heart & Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Halliday BP; National Heart & Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Prasad SK; National Heart & Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Barton PJ; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., O'Regan DP; MRC London Institute of Medical Sciences, Imperial College London, London, UK., Cook SA; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; National Heart Centre Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore., de Boer RA; Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands., Christiaans I; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Michels M; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, (ERN GUARD-HEART; https://guardheart.ern-net.eu).; Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands., Kramer CM; Department of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA., Ho CY; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA., Neubauer S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, NIHR Oxford Health Biomedical Research Centre, University of Oxford, Oxford, UK., Matthews PM; Department of Brain Sciences and UK Dementia Research Institute, Imperial College London, London, UK., Wilde AA; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, (ERN GUARD-HEART; https://guardheart.ern-net.eu).; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; ECGen, Cardiogenetics Focus Group of EHRA, France., Tardif JC; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Olivotto I; Department of Experimental and Clinical Medicine, Meyer Children Hospital, University of Florence, Florence, Italy., Adler A; Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., Goel A; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Ware JS; National Heart & Lung Institute, Imperial College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.; Program in Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bezzina CR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, (ERN GUARD-HEART; https://guardheart.ern-net.eu)., Watkins H; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Feb 06. Date of Electronic Publication: 2023 Feb 06.