Zobrazeno 1 - 10 of 317 pro vyhledávání: '"Bos, J.L."'
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Control of Epithelial Cell Migration and Invasion by the IKKbeta- and CK1alpha-Mediated Degradation of RAPGEF2
Autor: Magliozzi, R., Low, T.Y., Weijts, B.G.M.W., Cheng, T., Spanjaard, E., Mohammed, S., van Veen, A., Ovaa, H., de Rooij, J., Zwartkruis, G.J.T., Bos, J.L., de Bruin, A., Heck, A.J.R., Biomolecular Mass Spectrometry and Proteomics, Tissue Repair, Sub Biomol.Mass Spect. and Proteomics, Dep Pathobiologie, Sub Biomol.Mass Spectrometry & Proteom.
Publikováno v: Developmental Cell, 27, 574. Cell Press
Developmental Cell, 27(5), 574-585. Cell Press
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Epithelial cell migration is crucial for the development and regeneration of epithelial tissues. Aberrant regulation of epithelial cell migration has a major role in pathological processes such as the development of cancer metastasis and tissue fibro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3590f8632a0f912dcc46fab236d14
https://doi.org/10.1016/j.devcel.2013.10.023
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3
Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway
Autor: Meijer, L.A.T., Zhou, H., Chan, O.Y.A., Altelaar, A.F.M., Hennrich, M.L., Mohammed, S., Bos, J.L., Heck, A.J.R., Biomolecular Mass Spectrometry and Proteomics, Dep Scheikunde, Sub Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom.
Publikováno v: Molecular BioSystems, 9, 732. Royal Society of Chemistry
The small GTPase Rap1 is required for proper cell-cell junction formation and also plays a key role in mediating cAMP-induced tightening of adherens junctions and subsequent increased barrier function of endothelial cells. To further study how Rap1 c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cf436ac3ebf92d72c744cdee652bbc
http://ora.ox.ac.uk/objects/uuid:90d20e19-47d1-4959-98f4-d717e3706ac4
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4
Structural dynamics in the activation of Epac
Autor: Harper, S.M., Wienk, H., Wechselberger, R.W., Bos, J.L., Boelens, R., Rehmann, H., NMR-spectroscopie, Dep Scheikunde
Publikováno v: Journal of Biological Chemistry, 283(10), 6501. American Society for Biochemistry and Molecular Biology Inc.
Epac1 is a cAMP-responsive exchange factor for the small G-protein Rap. It consists of a regulatory region containing a cyclic nucleotide binding (CNB) domain and a catalytic region that activates Rap. In the absence of cAMP, access of Rap to the cat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a39c488539f0af84d2f867d3022e92c5
https://dspace.library.uu.nl/handle/1874/32232
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7
Differential fMet-Leu-Phe- and Platelet-activating Factor-induced Signaling Toward Ral Activation in Primary Human Neutrophils
Autor: M'Rabet, Laura, Coffer, P.J., Wolthuis, R.M.F., Zwartkruis, G.J.T., Koenderman, L., Bos, J.L.
Publikováno v: The Journal of Bioligical Chemistry, 274(31), 21847. The American Society for Biochemistry and Molecular Biology, Inc.
We have measured the activation of the small GTPase Ral in human neutrophils after stimulation with fMet- Leu-Phe (fMLP), platelet activating factor (PAF), and granulocyte macrophage-colony stimulating factor and compared it with the activation of tw
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::71b7a81f8df98e1d92f02c9cb68709f9
https://dspace.library.uu.nl/handle/1874/1657
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8
Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors
Autor: Osterop, A.P.R.M., Medema, R.H., Zon, G.C.M. van der, Bos, J.L., Möller, W., Maassen, J.A.
Publikováno v: European journal of biochemistry, 212, 477. Springer Verlag GmbH
Activation of the Ras proto-oncogene contributes in general to mitogenic activation of cells. We show here that epidermal growth factor (EGF) stimulates Ras.GTP formation very efficiently in a variety of cell lines expressing endogenous EGF receptors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::43ec8c0cda6753dd310fd934923346c5
https://dspace.library.uu.nl/handle/1874/7863
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9
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways
Autor: Burgering, B.M.T., Vries-Smits, A.M. de, Medema, R.H., Weeren, P.C. van, Tertoolen, L.G.J., Bos, J.L.
Publikováno v: Molecular and cellular biology, 13(12), 7248. American society for microbiology
Expression of p21rasAsn-17, a dominant negative mutant of p21ras that blocks p21ras activation by growth factors, inhibits activation of extracellular signal-regulated kinase 2 (ERK2) by insulin and platelet-derived growth factor in rat-1 cells [A. M
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::146c0b876ef83fd0c925c4dc28f1a8b7
https://dspace.library.uu.nl/handle/1874/7832
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10
The role of p21ras in receptor tyrosine kinase signaling
Autor: Medema, R.H., Bos, J.L.
Publikováno v: Critical reviews in oncogenesis, 4(6), 615. Begell House (formerly published by CRC Press)
The notion that ras proteins are required for the stimulation of mitogenesis by different receptor tyrosine kinases (RTKs) has spurred researchers to investigate the precise role of p21ras in signal transduction. A large number of stimuli can drive p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::39bf7f5f8743d762f37f79fabaec4f5d
https://dspace.library.uu.nl/handle/1874/7893
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