Flavone inspired discovery of benzylidenebenzofuran-3(2H)-ones (aurones) as potent inhibitors of human protein kinase CK2.

Autor: Protopopov MV; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine. Electronic address: mykola.protopopov@gmail.com., Vdovin VS; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine., Starosyla SA; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine., Borysenko IP; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine; LLC Scientific and Service Firm 'Otava', 117/125 Borschagivska St., Suite 79, 03056 Kyiv, Ukraine., Prykhod'ko AO; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine; LLC Scientific and Service Firm 'Otava', 117/125 Borschagivska St., Suite 79, 03056 Kyiv, Ukraine., Lukashov SS; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine., Bilokin YV; OTAVA Ltd., 400 Applewood Crescent, Unit 100, Vaughan, Ontario L4K 0C3, Canada., Bdzhola VG; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine., Yarmoluk SM; Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Sep; Vol. 102, pp. 104062. Date of Electronic Publication: 2020 Jun 30.

The synthesis of 5-hetarylamino-3-aryl-1H-indazoles as inhibitors of protein kinase CK2.

Autor: Protopopov, M. V.¹ mykola.protopopov@imbg.org.ua, Vdovin, V. S.¹, Lukashov, S. S.¹, Ostrynska, O. V.¹, Borysenko, I. P.^1,2, Borovykov, O. V.¹, Starosyla, S. A.¹, Bilokin, Y. V.³, Kukharenko, O. P.¹, Bdzhola, V. G.¹, Yarmoluk, S. M.¹

Publikováno v: Biopolymers & Cell. 2020, Vol. 36 Issue 6, p466-476. 11p.