LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

Autor: Tanya S Freedman, Ying X Tan, Katarzyna M Skrzypczynska, Boryana N Manz, Frances V Sjaastad, Helen S Goodridge, Clifford A Lowell, Arthur Weiss

Publikováno v: eLife, Vol 4 (2015)

Clustering of receptors associated with immunoreceptor tyrosine-based activation motifs (ITAMs) initiates the macrophage antimicrobial response. ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocytosis and macrophage activati

Externí odkaz: https://doaj.org/article/b7d5c1c494df490692db2bf1105c03ed

Physician-Specific Practice Patterns About Discharge Readiness and Heart Failure Utilization Outcomes

Autor: James A. de Lemos, Boryana N. Manz, Kamal Shemisa, Lonnie Roy, Rebecca Vigen, Sandeep R Das, Daniel Cheeran, Anish B. Bhatt

Publikováno v: Circulation: Cardiovascular Quality and Outcomes. 11

Background: Although hospitalization for acute decompensated heart failure (HF) is common and associated with poor outcomes and high costs, few evidence-based recommendations are available to guide patient management. Thus, management of inpatient HF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e8fe9135e846b1ef2fa569e1d9290e
https://doi.org/10.1161/circoutcomes.117.004365

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

Autor: Ying X Tan, Clifford A. Lowell, Helen S. Goodridge, Boryana N. Manz, Arthur Weiss, Tanya S. Freedman, Katarzyna M. Skrzypczynska, Frances V. Sjaastad

Publikováno v: eLife, Vol 4 (2015)
Freedman, TS; Tan, YX; Skrzypczynska, KM; Manz, BN; Sjaastad, FV; Goodridge, HS; et al.(2015). LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. eLife, 4(OCTOBER2015). doi: 10.7554/eLife.09183. UCSF: Retrieved from: http://www.escholarship.org/uc/item/7w90b8w0
eLife
eLife, vol 4, iss OCTOBER2015

Clustering of receptors associated with immunoreceptor tyrosine-based activation motifs (ITAMs) initiates the macrophage antimicrobial response. ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocytosis and macrophage activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c31bcc63b1eb8731e6d9e82e00217c8
https://elifesciences.org/articles/09183

Small molecule inhibition of Csk alters affinity recognition by T cells

Autor: Boryana N. Manz, Ed Palmer, Kevan M. Shokat, Arthur Weiss, Adam H. Courtney, Ying Xim Tan, Florentine U. Rutaganira

Publikováno v: eLife, vol 4, iss AUGUST2015
Manz, BN; Tan, YX; Courtney, AH; Rutaganira, F; Palmer, E; Shokat, KM; et al.(2015). Small molecule inhibition of Csk alters affinity recognition by T cells. eLife, 4(AUGUST2015). doi: 10.7554/eLife.08088. UCSF: Retrieved from: http://www.escholarship.org/uc/item/95p5m15s
eLife
eLife, Vol 4 (2015)

The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling. To investigate how Csk activity regulates T cell antigen receptor (TCR) signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5849a45ee081fe8e947fa12d4548ccd4
https://escholarship.org/uc/item/95p5m15s

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases

Autor: Tamiko R. Katsumoto, Makoto Kudo, Dean Sheppard, Elliott C. Callahan, Chun Chen, Connor E. Rosen, Boryana N. Manz, Jing W. Zhu, Arthur Weiss, Jae Won Lee, Joseph Lin, Xiaozhu Huang, Aparna Sundaram, Michael A. Matthay

Publikováno v: The Journal of clinical investigation, vol 123, iss 5
Katsumoto, TR; Kudo, M; Chen, C; Sundaram, A; Callahan, EC; Zhu, JW; et al.(2013). The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. Journal of Clinical Investigation, 123(5), 2037-2048. doi: 10.1172/JCI66397. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0j10d9pr

Increased airway smooth muscle (ASM) contractility and the development of airway hyperresponsiveness (AHR) are cardinal features of asthma, but the signaling pathways that promote these changes are poorly understood. Tyrosine phosphorylation is tight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640ec4966fe7c5f946d234dd9a8aadfa
https://escholarship.org/uc/item/0j10d9pr