Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.

Autor: Concato-Lopes VM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil. Electronic address: vir_93_@hotmail.com., Gonçalves-Lens MD; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, State University of Londrina, PR, Brazil., Tomiotto-Pellissier F; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil; Graduate Program in Biosciences and Biotechnology, Carlos Chagas Institute (ICC), Fiocruz, Curitiba, PR, Brazil; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Detoni MB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil., Cruz EMS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil., Bortoleti BTDS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil; Graduate Program in Biosciences and Biotechnology, Carlos Chagas Institute (ICC), Fiocruz, Curitiba, PR, Brazil., Carloto ACM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil., Rodrigues ACJ; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil; Graduate Program in Biosciences and Biotechnology, Carlos Chagas Institute (ICC), Fiocruz, Curitiba, PR, Brazil., Silva TF; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil., Siqueira EDS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil., de Matos RLN; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, State University of Londrina, PR, Brazil., Alves Cardoso IL; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, State University of Londrina, PR, Brazil., Conchon-Costa I; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil., Lazarin-Bidóia D; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil., Arakawa NS; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, State University of Londrina, PR, Brazil., Dekker RFH; Beta-Glucan Produtos Farmoquímicos-EIRELI, Lote 24(A) - Bloco Zirconia, Universidade Tecnológica Federal do Paraná, Avenida João Miguel Caram 731, CEP: 86036-700, Londrina, Paraná, Brazil., Mantovani MS; Laboratory of Toxicological Genetics, Department of Biology, State University of Londrina, PR, Brazil., Pavanelli WR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, State University of Londrina, PR, Brazil.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Jun; Vol. 128, pp. 155536. Date of Electronic Publication: 2024 Mar 13.

Biogenic silver nanoparticle exhibits schistosomicidal activity in vitro and reduces the parasitic burden in experimental schistosomiasis mansoni.

Autor: Detoni MB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil. Electronic address: marianabdetoni@gmail.com., Bortoleti BTDS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil; Graduate Program in Biosciences and Biotechnology, Carlos Chagas Institute, Fiocruz, Curitiba, Paraná, Brazil., Tomiotto-Pellissier F; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil; Graduate Program in Biosciences and Biotechnology, Carlos Chagas Institute, Fiocruz, Curitiba, Paraná, Brazil., Concato VM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Gonçalves MD; Laboratory of Biotransformation and Phytochemistry, Department of Chemistry, State University of Londrina, Londrina, Paraná, Brazil., Silva TF; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Ortiz LSF; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Gomilde AC; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Rodrigues ACJ; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., de Matos RLN; Laboratory of Animal Pathology, Department of Preventive Veterinary Medicine, State University of Londrina, Londrina, Paraná, Brazil., Bracarense APFRL; Laboratory of Animal Pathology, Department of Preventive Veterinary Medicine, State University of Londrina, Londrina, Paraná, Brazil., de Matos AMRN; Laboratory of Animal Pathology, Department of Preventive Veterinary Medicine, State University of Londrina, Londrina, Paraná, Brazil., Simão ANC; Clinical Analysis and Toxicology, Department of Pathology, State University of Londrina, Londrina, Paraná, Brazil., Endo TH; Laboratory of Basic and Applied Bacteriology, Department of Microbiology, State University of Londrina, Londrina, Paraná, Brazil., Kobayashi RKT; Laboratory of Basic and Applied Bacteriology, Department of Microbiology, State University of Londrina, Londrina, Paraná, Brazil., Nakazato G; Laboratory of Basic and Applied Bacteriology, Department of Microbiology, State University of Londrina, Londrina, Paraná, Brazil., Costa IN; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Conchon-Costa I; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Oliveira FJA; Laboratory of Experimental Parasitology, Department of Pathological Sciences, State University of Londrina, Paraná, Brazil., Pavanelli WR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Miranda-Sapla MM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil; Postgraduate Program in Pharmaceutical Science, University of Vale Do Itajaí, Santa Catarina, Brazil. Electronic address: mirandasapla@univali.br.

Publikováno v: Microbes and infection [Microbes Infect] 2023 Sep-Oct; Vol. 25 (7), pp. 105145. Date of Electronic Publication: 2023 Apr 28.

Caryocar coriaceum Wittm. fruit extracts as Leishmania inhibitors: in-vitro and in-silico approaches.

Autor: Tomiotto-Pellissier F; Biosciences and Biotechnology Graduate Program, Carlos Chagas Institute (ICC), Fiocruz, Curitiba, Paraná, Brazil.; Department of Pathology Science, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Alves DR; Department of Natural Sciences, Ceará State University, Fortaleza, Ceará, Brazil.; Theoretical and Electrochemical Chemistry Group, Faculty of Philosophy Dom Aureliano Matos, State University of Ceará, Limoeiro do Norte, Ceará, Brazil., Morais SM; Department of Natural Sciences, Ceará State University, Fortaleza, Ceará, Brazil., Bortoleti BTDS; Biosciences and Biotechnology Graduate Program, Carlos Chagas Institute (ICC), Fiocruz, Curitiba, Paraná, Brazil.; Department of Pathology Science, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Gonçalves MD; Department of Chemistry, Center of Exact Sciences, State University of Londrina, Londrina, Paraná, Brazil., Silva TF; Department of Pathology Science, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Tavares ER; Department of Microbiology, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Yamauchi LM; Department of Microbiology, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Costa IN; Department of Pathology Science, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Marinho ES; Theoretical and Electrochemical Chemistry Group, Faculty of Philosophy Dom Aureliano Matos, State University of Ceará, Limoeiro do Norte, Ceará, Brazil., Marinho MM; Iguatu Faculty of Education, Science and Letters, State University of Ceará, Iguatu, Ceará, Brazil., Conchon-Costa I; Department of Pathology Science, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Miranda-Sapla MM; Department of Pathology Science, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Pavanelli WR; Biosciences and Biotechnology Graduate Program, Carlos Chagas Institute (ICC), Fiocruz, Curitiba, Paraná, Brazil.; Department of Pathology Science, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2022 Oct; Vol. 40 (17), pp. 8040-8055. Date of Electronic Publication: 2021 Mar 26.

Solidagenone in vivo leishmanicidal activity acting in tissue repair response, and immunomodulatory capacity in Leishmania amazonensis.

Autor: Bortoleti BTDS; Biosciences and Biotechnology Postgraduate Program, Carlos Chagas Institute (ICC/Fiocruz-PR), Curitiba, Paraná, Brazil; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Detoni MB; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Gonçalves MD; State University of Londrina (UEL/PR), Laboratory of Biotransformation and Phytochemistry, Londrina, Paraná, Brazil., Tomiotto-Pellissier F; Biosciences and Biotechnology Postgraduate Program, Carlos Chagas Institute (ICC/Fiocruz-PR), Curitiba, Paraná, Brazil; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Silva TF; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Concato VM; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Rodrigues ACJ; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Carloto AC; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., de Matos RLN; State University of Londrina (UEL/PR), Laboratory of Biotransformation and Phytochemistry, Londrina, Paraná, Brazil., Fattori V; State University of Londrina (UEL/PR), Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Londrina, Paraná, Brazil., Arakawa NS; State University of Londrina (UEL/PR), Laboratory of Biotransformation and Phytochemistry, Londrina, Paraná, Brazil., Verri WA Jr; State University of Londrina (UEL/PR), Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Londrina, Paraná, Brazil., Costa IN; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Conchon-Costa I; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Miranda-Sapla MM; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Wowk PF; Carlos Chagas Institute (ICC/Fiocruz-PR), Laboratory of Molecular Virology, Curitiba, Paraná, Brazil. Electronic address: pryscilla.wowk@fiocruz.br., Pavanelli WR; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil. Electronic address: wanderpavanelli@uel.br.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2022 Jul 01; Vol. 361, pp. 109969. Date of Electronic Publication: 2022 May 05.

Thiohydantoins as anti-leishmanial agents: n vitro biological evaluation and multi-target investigation by molecular docking studies.

Autor: Camargo PG; Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina, Brazil., Bortoleti BTDS; Programa de Pós Graduação em Biociências e Biotecnologia, Instituto Carlos Chagas, Curitiba, Brazil., Fabris M; Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina, Brazil., Gonçalves MD; Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina, Brazil., Tomiotto-Pellissier F; Programa de Pós Graduação em Biociências e Biotecnologia, Instituto Carlos Chagas, Curitiba, Brazil., Costa IN; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil., Conchon-Costa I; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil., Lima CHDS; Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Pavanelli WR; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil., Bispo MLF; Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina, Brazil., Macedo F Jr; Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina, Brazil.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2022 Apr; Vol. 40 (7), pp. 3213-3222. Date of Electronic Publication: 2020 Nov 13.