Spadin, a Sortilin-derived peptide: a new concept in the antidepressant drug design

Autor: Heurteaux Catherine, Mazella Jean, Borsotto Marc

Publikováno v: Oléagineux, Corps gras, Lipides, Vol 18, Iss 4, Pp 202-207 (2011)

Depression is the most common of psychiatric illnesses. The design of effective treatments for this disorder is a challenging process. Recently, the two-pore domain potassium channel TREK-1 has been identified as a new target in depression, and its a

Externí odkaz: https://doaj.org/article/2b94c1f94dfe41e9acf32e9f2d51b510

Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b

Autor: Nasr, Nathalie, Faucherre, Adèle, Borsotto, Marc, Heurteaux, Catherine, Mazella, Jean, Jopling, Chris, Moha ou Maati, Hamid

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-33664-9⟩
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-33664-9⟩

KCNK2 is a 2 pore domain potassium channel involved in maintaining cellular membrane resting potentials. Although KCNK2 is regarded as a mechanosensitive ion channel, it can also be gated chemically. Previous research indicates that KCNK2 expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4eb19f6b90d43ed36882f65505fe5dca
http://link.springer.com/article/10.1038/s41598-018-33664-9

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M-type KCNQ2–KCNQ3 potassium channels are modulated by the KCNE2 subunit

Autor: Tinel, Norbert, Diochot, Sylvie, Lauritzen, Inger, Barhanin, Jacques, Lazdunski, Michel, Borsotto, Marc ^*

Publikováno v: In FEBS Letters 2000 480(2):137-141