Identifying latent disease factors differently expressed in patient subgroups using group factor analysis

Autor: Ferreira, Fabio S., Ashburner, John, Bouzigues, Arabella, Suksasilp, Chatrin, Russell, Lucy L., Foster, Phoebe H., Ferry-Bolder, Eve, van Swieten, John C., Jiskoot, Lize C., Seelaar, Harro, Sanchez-Valle, Raquel, Laforce, Robert, Graff, Caroline, Galimberti, Daniela, Vandenberghe, Rik, de Mendonca, Alexandre, Tiraboschi, Pietro, Santana, Isabel, Gerhard, Alexander, Levin, Johannes, Sorbi, Sandro, Otto, Markus, Pasquier, Florence, Ducharme, Simon, Butler, Chris R., Ber, Isabelle Le, Finger, Elizabeth, Tartaglia, Maria C., Masellis, Mario, Rowe, James B., Synofzik, Matthis, Moreno, Fermin, Borroni, Barbara, Kaski, Samuel, Rohrer, Jonathan D., Mourao-Miranda, Janaina

In this study, we propose a novel approach to uncover subgroup-specific and subgroup-common latent factors addressing the challenges posed by the heterogeneity of neurological and mental disorders, which hinder disease understanding, treatment develo

Externí odkaz: http://arxiv.org/abs/2410.07890

Plasma biomarkers increase diagnostic confidence in patients with Alzheimer’s disease or frontotemporal lobar degeneration

Autor: Daniele Altomare, Ilenia Libri, Antonella Alberici, Jasmine Rivolta, Alessandro Padovani, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Barbara Borroni

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-9 (2024)

Abstract Background The recent development of techniques to assess plasma biomarkers has changed the way the research community envisions the future of diagnosis and management of Alzheimer’s disease (AD) and other neurodegenerative disorders. This

Externí odkaz: https://doaj.org/article/2c84c3f7a5c442ecaaff5bad82316c3a

A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors

Autor: Imogen J. Swift, Rosa Rademakers, NiCole Finch, Matt Baker, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Giacomina Rossi, Matthis Synofzik, Carlo Wilke, David Mengel, Caroline Graff, Leonel T. Takada, Raquel Sánchez-Valle, Anna Antonell, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Stefanie Schreiber, Stefan Vielhaber, Philipp Arndt, Isabel Santana, Maria Rosario Almeida, Fermín Moreno, Myriam Barandiaran, Alazne Gabilondo, Johannes Stubert, Estrella Gómez-Tortosa, Pablo Agüero, M. José Sainz, Tomohito Gohda, Maki Murakoshi, Nozomu Kamei, Sarah Kittel-Schneider, Andreas Reif, Johannes Weigl, Jinlong Jian, Chuanju Liu, Ginette Serrero, Thomas Greither, Gerit Theil, Ebba Lohmann, Stefano Gazzina, Silvia Bagnoli, Giovanni Coppola, Amalia Bruni, Mirja Quante, Wieland Kiess, Andreas Hiemisch, Anne Jurkutat, Matthew S. Block, Aaron M. Carlson, Geir Bråthen, Sigrid Botne Sando, Gøril Rolfseng Grøntvedt, Camilla Lauridsen, Amanda Heslegrave, Carolin Heller, Emily Abel, Alba Gómez-Núñez, Roger Puey, Andrea Arighi, Enmanuela Rotondo, Lize C. Jiskoot, Lieke H. H. Meeter, João Durães, Marisa Lima, Miguel Tábuas-Pereira, João Lemos, Bradley Boeve, Ronald C. Petersen, Dennis W. Dickson, Neill R. Graff-Radford, Isabelle LeBer, Leila Sellami, Foudil Lamari, Fabienne Clot, Barbara Borroni, Valentina Cantoni, Jasmine Rivolta, Alberto Lleó, Juan Fortea, Daniel Alcolea, Ignacio Illán-Gala, Lucie Andres-Cerezo, Philip Van Damme, Jordi Clarimon, Petra Steinacker, Emily Feneberg, Markus Otto, Emma L. van der Ende, John C. van Swieten, Harro Seelaar, Henrik Zetterberg, Aitana Sogorb-Esteve, Jonathan D. Rohrer

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Abstract Background Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This has led to a number

Externí odkaz: https://doaj.org/article/1d7c751ac55c494a90e49ef788756561

The role of parvalbumin interneuron dysfunction across neurodegenerative dementias

Autor: Smeralda, Carmelo Luca, Pandit, Siddhartha, Turrini, Sonia, Reilly, Julianne, Palmisano, Annalisa, Sprugnoli, Giulia, Hampel, Harald, Benussi, Alberto, Borroni, Barbara, Press, Daniel, Rotenberg, Alexander, El Fakhri, Georges, Koch, Giacomo, Rossi, Simone, Santarnecchi, Emiliano

Publikováno v: In Ageing Research Reviews November 2024 101

Fall of dwarfs: micro and macroeconomic determinants of the disappearance of European small banks

Autor: Poli, Federica, Rossi, Simone, Borroni, Mariarosa

Publikováno v: In Journal of International Financial Markets, Institutions & Money October 2024 96