Výsledky vyhledávání - "Borreguero, Jose M."

Akademický článek

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Akademický článek

Generation of the configurational ensemble of an intrinsically disordered protein from unbiased molecular dynamics simulation

Autor: Shrestha, Utsab R., Juneja, Puneet, Zhang, Qiu, Gurumoorthy, Viswanathan, Borreguero, Jose M., Urban, Volker, Cheng, Xiaolin, Pingali, Sai Venkatesh, Smith, Jeremy C., O’Neill, Hugh M., Petridis, Loukas

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2019 Oct 01. 116(41), 20446-20452.

Externí odkaz: https://www.jstor.org/stable/26857992

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Solvent and mutation effects on the nucleation of amyloid $\beta$-protein folding

Autor: Cruz, Luis, Urbanc, Brigita, Borreguero, Jose M., Lazo, Noel D., Teplow, David B., Stanley, H. Eugene

Experimental evidence suggests that the folding and aggregation of the amyloid $\beta$-protein (A$\beta$) into oligomers is a key pathogenetic event in Alzheimer's disease (AD). Inhibiting the pathologic folding and oligomerization of A$\beta$ could

Externí odkaz: http://arxiv.org/abs/q-bio/0510048

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A possible mechanism for cold denaturation of proteins at high pressure

Autor: Marques, Manuel I., Borreguero, Jose M., Stanley, H. Eugene, Dokholyan, Nikolay V.

We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure w

Externí odkaz: http://arxiv.org/abs/cond-mat/0212639

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