Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma.

Autor: Marasco M; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kumar D; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Seale T; Department of Oncology, Cancer Genetics and Epigenetics Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Borrego SG; Department of Oncology, Cancer Genetics and Epigenetics Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kaplun E; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Aricescu I; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA., Cole S; Department of Oncology, Cancer Genetics and Epigenetics Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Qeriqi B; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Qiu J; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chen X; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bahr A; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fidele D; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hofmann MH; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria., Gerlach D; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria., Savarese F; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria., Merghoub T; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Wolchok JD; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Yao Z; Mechanistic Biology, Loxo Oncology at Lilly, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Solit D; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Misale S; Department of Oncology, Cancer Genetics and Epigenetics Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: smisale1@jh.edu., Rosen N; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: rosenn@mskcc.org.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Nov 19; Vol. 5 (11), pp. 101818. Date of Electronic Publication: 2024 Nov 01.