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A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.

Autor: Lyon M; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110., Li P; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110., Ferreira JJ; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110., Lazarenko RM; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232., Kharade SV; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232., Kramer M; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232., McClenahan SJ; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232., Days E; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232., Bauer JA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232., Spitznagel BD; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232., Weaver CD; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232., Borrego Alvarez A; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110., Puga Molina LC; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110., Lybaert P; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110.; Laboratoire de recherche en Reproduction humaine, Université Libre de Bruxelles, Bruxelles 1050, Belgium., Khambekar S; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110., Liu A; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110., Lindsley CW; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232.; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232., Denton J; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232.; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232., Santi CM; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 24; Vol. 120 (4), pp. e2212338120. Date of Electronic Publication: 2023 Jan 17.