Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Borna Novak"'
Autor:
Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman
Publikováno v:
eLife, Vol 12 (2023)
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least
Externí odkaz:
https://doaj.org/article/376094e3254c440f9fdb0628df390ca2
Publikováno v:
Journal of Chemical Information and Modeling. 63:2769-2782
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39853fb5444a81882e36565056180150
https://doi.org/10.1021/acs.jcim.3c00155
https://doi.org/10.1021/acs.jcim.3c00155
Autor:
Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baf0065e922a07922b9b71aa51f6b7c7
https://doi.org/10.7554/elife.83602.sa2
https://doi.org/10.7554/elife.83602.sa2
Autor:
Artur Meller, Jeffrey M. Lotthammer, Louis G. Smith, Borna Novak, Lindsey A. Lee, Catherine C. Kuhn, Lina Greenberg, Leslie A. Leinwand, Michael J. Greenberg, Gregory R. Bowman
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc4bdc82f87b72d6bdd502517eef091
https://doi.org/10.1101/2022.09.05.506254
https://doi.org/10.1101/2022.09.05.506254
Autor:
Zhiwei Liu, Borna Novak, Matthew Connolly, Nicholas Cope, Maria Cavallo, Amber Gunderwala, Zhihong Wang
Publikováno v:
Journal of Biological Chemistry. 295:2407-2420
Class 3 mutations in B-Raf proto-oncogene, Ser/Thr kinase (BRAF), that result in kinase-impaired or kinase-dead BRAF have the highest mutation frequency in BRAF gene in lung adenocarcinoma. Several studies have reported that kinase-dead BRAF variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b2876f940d14709508a473296eac7ca
https://doi.org/10.1074/jbc.ra119.011536
https://doi.org/10.1074/jbc.ra119.011536
Publikováno v:
Biophysical Journal. 122:183a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9175eb958a382254bc7c5d1742c8229
https://doi.org/10.1016/j.bpj.2022.11.1128
https://doi.org/10.1016/j.bpj.2022.11.1128
Autor:
Zhiwei Liu, Zhihong Wang, Borna Novak, Kenneth Wong, Amber Gunderwala, Maria Cavallo, Yana Li, Nicholas Cope, Christine Candelora
Publikováno v:
ChemBioChem. 20:2850-2861
The most prevalent BRAF mutation, V600E, occurs frequently in melanoma and other cancers. Although extensive progress has been made toward understanding the biology of RAF kinases, little in vitro characterization of full-length BRAFV600E is availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d489f12ef1bd20f5b082e23c5912a5b7
https://doi.org/10.1002/cbic.201900266
https://doi.org/10.1002/cbic.201900266
Autor:
Neha Vithani, Gregory R. Bowman, Michael D. Ward, Jonathan H. Borowsky, Sukrit Singh, Borna Novak, Maxwell I. Zimmerman
Publikováno v:
Biophysical Journal
Coronaviruses have caused multiple epidemics in the past two decades, in addition to the current COVID-19 pandemic that is severely damaging global health and the economy. Coronaviruses employ between twenty and thirty proteins to carry out their vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfb2d30869b18525119b0c7cdf2d3d4
http://europepmc.org/articles/PMC8007187
http://europepmc.org/articles/PMC8007187
Publikováno v:
Biophysical Journal. 121:260a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb24a454832abb92ea501c01175065d
https://doi.org/10.1016/j.bpj.2021.11.1441
https://doi.org/10.1016/j.bpj.2021.11.1441
Autor:
Nicholas J, Cope, Borna, Novak, Zhiwei, Liu, Maria, Cavallo, Amber Y, Gunderwala, Matthew, Connolly, Zhihong, Wang
Publikováno v:
J Biol Chem
Class 3 mutations in B-Raf proto-oncogene, Ser/Thr kinase (BRAF), that result in kinase-impaired or kinase-dead BRAF have the highest mutation frequency in BRAF gene in lung adenocarcinoma. Several studies have reported that kinase-dead BRAF variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::260e67901a297597102059d17e8331b1
https://pubmed.ncbi.nlm.nih.gov/31929109
https://pubmed.ncbi.nlm.nih.gov/31929109