Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Autor: Ghislaine Scelo, Mark P. Purdue, Kevin M. Brown, Mattias Johansson, Zhaoming Wang, Jeanette E. Eckel-Passow, Yuanqing Ye, Jonathan N. Hofmann, Jiyeon Choi, Matthieu Foll, Valerie Gaborieau, Mitchell J. Machiela, Leandro M. Colli, Peng Li, Joshua N. Sampson, Behnoush Abedi-Ardekani, Celine Besse, Helene Blanche, Anne Boland, Laurie Burdette, Amelie Chabrier, Geoffroy Durand, Florence Le Calvez-Kelm, Egor Prokhortchouk, Nivonirina Robinot, Konstantin G. Skryabin, Magdalena B. Wozniak, Meredith Yeager, Gordana Basta-Jovanovic, Zoran Dzamic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Neonila Szeszenia-Dabrowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Laura Baglietto, Heiner Boeing, Kay-Tee Khaw, Elisabete Weiderpass, Borje Ljungberg, Raviprakash T. Sitaram, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Kvetoslava Koppova, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Paul Pharoah, Gabriella Andreotti, Laura E. Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Peter Kraft, Mark A. Preston, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Amanda Black, Neal D. Freedman, Wen-Yi Huang, John G. Anema, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E. Moore, Christopher Wood, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G. Mark Lathrop, Nathaniel Rothman, Jean-Francois Deleuze, James D. McKay, Alexander S. Parker, Xifeng Wu, Richard S. Houlston, Paul Brennan, Stephen J. Chanock

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Risk for renal cell carcinoma (RCC) is higher when there are first-degree family members with the disease. Here, Scelo and colleagues perform a genome-wide association meta-analysis and new genome-wide scan to identify seven new loci with significant

Externí odkaz: https://doaj.org/article/ad47bc9f89b649d087928811441ea01d

Local Treatment of Recurrent Renal Cell Carcinoma May Have a Significant Survival Effect Across All Risk-of-recurrence Groups

Autor: Lorenzo Marconi, Teele Kuusk, Umberto Capitanio, Christian Beisland, Thomas Lam, Sergio Fernandez Pello, Grant D. Stewart, Tobias Klatte, Alessandro Volpe, Borje Ljungberg, Saeed Dabestani, Axel Bex

Publikováno v: European Urology Open Science. 47:65-72

BACKGROUND: Retrospective comparative studies suggest a survival benefit after complete local treatment of recurrence (LTR) in renal cell carcinoma (RCC), which may be largely due to an indication bias. OBJECTIVE: To determine the role of LTR in a ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41c8d708cf6a665069a349dd8d3e087
https://doi.org/10.1016/j.euros.2022.11.008

Kidney tumor biopsy – an unmet need for personalized treatment

Autor: Borje Ljungberg

Publikováno v: Scandinavian Journal of Urology. 56:373-374

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25357a62cee6817d47f7fc561d59f7e8
https://doi.org/10.1080/21681805.2022.2119275

Expression of HIF‑α and their association with clinicopathological parameters in clinical renal cell carcinoma

Autor: Raviprakash T. Sitaram, Börje Ljungberg

Publikováno v: Upsala Journal of Medical Sciences, Vol 129, Pp 1-8 (2024)

Objectives: This study aimed to assess the cellular localization and expression levels of hypoxia-inducible factor (HIF) -α proteins (specifically HIF-1α, HIF-2α, and HIF-3α) that play a role in the hypoxia pathway and to determine their correlat

Externí odkaz: https://doaj.org/article/87468b09f05246208a5784c5638a4cf0

Outcome after resection of occult and non-occult lymph node metastases at the time of nephrectomy

Autor: Teele, Kuusk, Tobias, Klatte, Patricia, Zondervan, Brunolf, Lagerveld, Niels, Graafland, Kees, Hendricksen, Umberto, Capitanio, Andrea, Minervini, Grant D, Stewart, Borje, Ljungberg, Simon, Horenblas, Axel, Bex

Publikováno v: World journal of urology. 39(9)

There is sparse evidence on outcomes of resected occult LN metastases at the time of nephrectomy (synchronous disease). We sought to analyse a large international cohort of patients and to identify clinico-pathological predictors of long-term surviva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73a3e379ee6b0a0e2d67f64ebf02ca3d
https://pubmed.ncbi.nlm.nih.gov/33634323