Deregulated Nras expression in knock-in animals harboring a gammaretroviral long terminal repeat at the Nras/Csde1 locus.

Autor: Borja Ballarín-González, Louise Berkhoudt Lassen, Randi Jessen, Annette Füchtbauer, Ernst-Martin Füchtbauer, Finn Skou Pedersen

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56029 (2013)

To investigate mechanisms and phenotypic effects of insertional mutagenesis by gammaretroviruses, we have developed mouse lines containing a single Akv 1-99 long terminal repeat (LTR) and a floxed PGK/Tn5 neomycin cassette at the Nras proto-oncogene

Externí odkaz: https://doaj.org/article/6352d533bc8d46d188d090b649b97ff0

Intraintestinal and Parenteral Administration of an Insulin Analogue Leads to Comparable Activation of Signaling Downstream of the Insulin Receptor in the Small Intestine

Autor: Jonas Ahnfelt-Rønne, Henning Hvid, Borja Ballarín-González, Trine Porsgaard, Erica Nishimura, Mikkel S Jørgensen, Kim Kristensen, Jonas Kildegaard, Bo Falck Hansen

Publikováno v: J Diabetes Sci Technol

Background: Oral delivery of insulin was recently demonstrated to have therapeutic relevance in patients with diabetes. Insulin receptors are expressed in the gastrointestinal tract and can be activated by insulin in the bloodstream, but it is not kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f2a64941762218aa25b5377b26f09a
https://pubmed.ncbi.nlm.nih.gov/31189343

Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions

Autor: Borja Ballarín-González, Kenneth A. Howard

Publikováno v: Gonzalez, B B & Howard, K 2012, ' Polycation-based nanoparticle delivery of RNAi therapeutics : Adverse effects and solutions ', Advanced Drug Delivery Reviews, vol. 64, no. 15, pp. 1717-1729 . https://doi.org/10.1016/j.addr.2012.07.004

Small interfering RNA (siRNA) that silence genes by the process of RNA interference offers a new therapeutic modality for disease treatment. Polycation-based nanoparticles termed polyplexes have been developed to maximise extracellular and intracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e548da12d83db7e5ba532dcd843b01b
https://doi.org/10.1016/j.addr.2012.07.004

Clinical translation of RNAi-based treatments for respiratory diseases

Autor: Troels Bo Thomsen, Kenneth A. Howard, Borja Ballarín-González

Publikováno v: Drug Delivery and Translational Research
Gonzalez, B B, Thomsen, T B & Howard, K 2013, ' Clinical translation of RNAi-based treatments for respiratory diseases ', Drug Delivery and Translational Research, vol. 3, no. 1, pp. 84-99 . https://doi.org/10.1007/s13346-012-0098-7

The ability to harness the RNA interference (RNAi) mechanism as a potential potent therapeutic has attracted great interest from academia and industry. Numerous preclinical and recent clinical trials have demonstrated the effectiveness of RNAi trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8a935b91f67dde8cd70dfbc636aee0
https://pubmed.ncbi.nlm.nih.gov/25787868

Mucosal Delivery of RNAi Therapeutics

Autor: Ebbe Juel Bech Nielsen, Troels Bo Thomsen, Kenneth A. Howard, Borja Ballarín González

Publikováno v: Advances in Delivery Science and Technology ISBN: 9781461447436
Gonzalez, B B, Nielsen, E J B, Thomsen, T B & Howard, K 2013, Mucosal Delivery of RNAi Therapeutics . in K A Howard (ed.), RNA Interference from Biology to Therapeutics . Springer, Advances in Delivery Science and Technology, pp. 97-125 . < http://link.springer.com/chapter/10.1007%2F978-1-4614-4744-3_5#page-1 >

The effectiveness of RNA interference-based drugs is dependent on accumulation at the target site in therapeutically relevant amounts. Local administration to the mucosal surfaces lining the respiratory, gastrointestinal and genitourinary tracts allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0bc07944d09180d2d794887d0e9471
https://doi.org/10.1007/978-1-4614-4744-3_5