Synthesis and biological evaluation of - n[4-(2- trans-[([2,6-diamino-4(3 H)-oxopyrimidin-5-yl]methyl)thio]cyclobutyl)benzoyl] -l-glutamic acid a novel 5-thiapyrimidinone inhibitor of dihydrofolate reductase.

Autor: Varney, Michael D., Romines, William H., Boritzki, Theodore, Margosiak, Stephen A., Bartlett, Charlotte, Howland, Eleanor J.

Publikováno v: Journal of Heterocyclic Chemistry; Sep1995, Vol. 32 Issue 5, p1493-1498, 6p

AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies.

Autor: Webber, S., Bartlett, Charlotte A., Boritzki, Theodore J., Hilliard, Jill A., Howland, Eleanor F., Johnston, Amanda L., Kosa, Maha, Margosiak, Stephen A., Morse, Cathy A., Shetty, Bhasker V., Bartlett, C A, Boritzki, T J, Hillard, J A, Howland, E F, Johnston, A L, Kosa, M, Margosiak, S A, Morse, C A, Shetty, B V

Publikováno v: Cancer Chemotherapy & Pharmacology; Mar1996, Vol. 37 Issue 6, p509-517, 9p

AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

Autor: Boritzki, Theodore, Barlett, Charlotte, Zhang, Cathy, Howland, Eleanor, Margosiak, Stephen, Palmer, Cindy, Romines, William, Jackson, Robert

Publikováno v: Investigational New Drugs; October 1996, Vol. 14 Issue: 3 p295-303, 9p

Purine and pyrimidine ribonucleotide contents of rat liver and hepatoma 3924A and the effect of ischemia

Autor: Jackson, Robert C., Boritzki, Theodore J., Morris, Harold P., Weber, George

Publikováno v: In Life Sciences 1976 19(10):1531-1536

Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

Autor: Tikhe JG; Pfizer Global R&D--La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, USA. jayashree.tikhe@pfizer.com, Webber SE, Hostomsky Z, Maegley KA, Ekkers A, Li J, Yu XH, Almassy RJ, Kumpf RA, Boritzki TJ, Zhang C, Calabrese CR, Curtin NJ, Kyle S, Thomas HD, Wang LZ, Calvert AH, Golding BT, Griffin RJ, Newell DR

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2004 Oct 21; Vol. 47 (22), pp. 5467-81.