Photochemical properties of photosystem 1 immobilized in a mesoporous semiconductor matrix.

Autor: Nikandrov, V.¹ nikandrov@inbi.ras.ru, Borisova, Ya.¹, Bocharov, E.¹, Usachev, M.², Nizova, G.², Nadtochenko, V.³, Lukashev, E.⁴, Trubitsin, B.⁴, Tikhonov, A.⁴, Kurashov, V.⁵, Mamedov, M.⁵, Semenov, A.⁵

Publikováno v: High Energy Chemistry. May2012, Vol. 46 Issue 3, p200-205. 6p.

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A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways.

Autor: Kalitin NN; N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478, Moscow, Russia. Electronic address: f.oskolov@mail.ru., Ektova LV; N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478, Moscow, Russia., Kostritsa NS; M.V. Lomonosov Moscow State University, 1 Leninskiye Gory, 119234, Moscow, Russia., Sivirinova AS; M.V. Lomonosov Moscow State University, 1 Leninskiye Gory, 119234, Moscow, Russia., Kostarev AV; University of Tübingen, Geschwister-Scholl-Platz, 72074, Tübingen, Germany., Smirnova GB; N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478, Moscow, Russia., Borisova YA; N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478, Moscow, Russia., Golubeva IS; N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478, Moscow, Russia., Ermolaeva EV; I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991, Moscow, Russia., Vergun MA; I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991, Moscow, Russia., Babaeva MA; M.V. Lomonosov Moscow State University, 1 Leninskiye Gory, 119234, Moscow, Russia., Lushnikova AA; N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478, Moscow, Russia., Karamysheva AF; N.N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478, Moscow, Russia.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2022 Sep 01; Vol. 364, pp. 110056. Date of Electronic Publication: 2022 Jul 21.

Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E Conjugate.

Autor: Machulkin AE; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Uspenskaya AA; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Zyk NU; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Nimenko EA; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Ber AP; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Petrov SA; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Polshakov VI; Center for Magnetic Tomography and Spectroscopy, Faculty of Fundamental Medicine, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Shafikov RR; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, Moscow 117997, Russian Federation., Skvortsov DA; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Plotnikova EA; National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2 Botkinskiy Proezd, 3, Moscow 125284, Russian Federation., Pankratov AA; National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2 Botkinskiy Proezd, 3, Moscow 125284, Russian Federation., Smirnova GB; N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russian Federation., Borisova YA; N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russian Federation., Pokrovsky VS; N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russian Federation.; RUDN University, Miklukho-Maklaya Street 6, Moscow 117198, Russian Federation., Kolmogorov VS; National University of Science and Technology MISiS, 9 Leninskiy Prospekt, Moscow 119049, Russian Federation., Vaneev AN; National University of Science and Technology MISiS, 9 Leninskiy Prospekt, Moscow 119049, Russian Federation., Khudyakov AD; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Chepikova OE; Department of Biotechnology, Sirius University of Science and Technology, 1 Olympic Avenue, Sochi 354340, Russian Federation., Kovalev S; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Zamyatnin AA Jr; Department of Biotechnology, Sirius University of Science and Technology, 1 Olympic Avenue, Sochi 354340, Russian Federation.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya Street 8-2, Moscow 119991, Russian Federation.; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow 119992, Russian Federation.; Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, U.K., Erofeev A; National University of Science and Technology MISiS, 9 Leninskiy Prospekt, Moscow 119049, Russian Federation., Gorelkin P; National University of Science and Technology MISiS, 9 Leninskiy Prospekt, Moscow 119049, Russian Federation., Beloglazkina EK; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Zyk NV; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Khazanova ES; LLC Izvarino-Pharma, v. Vnukovskoe, Vnukovskoe Shosse, Fifth km., Building 1, Moscow 108817, Russian Federation., Majouga AG; Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation.; National University of Science and Technology MISiS, 9 Leninskiy Prospekt, Moscow 119049, Russian Federation.; Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, Moscow 125047, Russian Federation.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Dec 09; Vol. 64 (23), pp. 17123-17145. Date of Electronic Publication: 2021 Nov 19.