Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Borislav Dejanovic"'
Autor:
Sameer Aryal, Kevin Bonanno, Bryan Song, D.R. Mani, Hasmik Keshishian, Steven A. Carr, Morgan Sheng, Borislav Dejanovic
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112497- (2023)
Summary: Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased proteomic profiling of synapses purified from the dorsolateral pref
Externí odkaz:
https://doaj.org/article/0709b3c745bc4d1e9ed02f715192f2bd
Autor:
Ashley L Comer, Tushare Jinadasa, Balaji Sriram, Rhushikesh A Phadke, Lisa N Kretsge, Thanh P H Nguyen, Giovanna Antognetti, James P Gilbert, Jungjoon Lee, Elena R Newmark, Frances S Hausmann, SaraAnn Rosenthal, Kevin Liu Kot, Yenyu Liu, William W Yen, Borislav Dejanovic, Alberto Cruz-Martín
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000604 (2020)
Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased expression of the immune gene C4 has been linked to a greater risk of developing schizophrenia; however, it is not known whether C4 plays a causative role in this br
Externí odkaz:
https://doaj.org/article/34077f597f684c8f99d99f9949e1343a
Autor:
Tiffany Wu, Borislav Dejanovic, Vineela D. Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H. Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael C. Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2111-2123.e6 (2019)
Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focuse
Externí odkaz:
https://doaj.org/article/6cf938f6916a4deca5b7f57d27bda622
Autor:
Borislav Dejanovic, Dennis Lal, Claudia B. Catarino, Sita Arjune, Abdel A. Belaidi, Holger Trucks, Christian Vollmar, Rainer Surges, Wolfram S. Kunz, Susanne Motameny, Janine Altmüller, Anna Köhler, Bernd A. Neubauer, EPICURE Consortium, Peter Nürnberg, Soheyl Noachtar, Günter Schwarz, Thomas Sander
Publikováno v:
Neurobiology of Disease, Vol 67, Iss , Pp 88-96 (2014)
Gephyrin is a postsynaptic scaffolding protein, essential for the clustering of glycine and γ-aminobutyric acid type-A receptors (GABAARs) at inhibitory synapses. An impairment of GABAergic synaptic inhibition represents a key pathway of epileptogen
Externí odkaz:
https://doaj.org/article/0d3c71caf84e4afe864b20bdcfaa14a1
Autor:
Dennis Lal, Eva M Reinthaler, Borislav Dejanovic, Patrick May, Holger Thiele, Anna-Elina Lehesjoki, Günter Schwarz, Erik Riesch, M Arfan Ikram, Cornelia M van Duijn, Andre G Uitterlinden, Albert Hofman, Hannelore Steinböck, Ursula Gruber-Sedlmayr, Birgit Neophytou, Federico Zara, Andreas Hahn, Genetic Commission of the Italian League against Epilepsy, EuroEPINOMICS CoGIE Consortium, Padhraig Gormley, Felicitas Becker, Yvonne G Weber, Maria Roberta Cilio, Wolfram S Kunz, Roland Krause, Fritz Zimprich, Johannes R Lemke, Peter Nürnberg, Thomas Sander, Holger Lerche, Bernd A Neubauer
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150426 (2016)
ObjectiveThe SCN1A gene, coding for the voltage-gated Na+ channel alpha subunit NaV1.1, is the clinically most relevant epilepsy gene. With the advent of high-throughput next-generation sequencing, clinical laboratories are generating an ever-increas
Externí odkaz:
https://doaj.org/article/57fdd972a5f4468aab854329d85979d2
Autor:
Borislav Dejanovic, Marcus Semtner, Silvia Ebert, Tobias Lamkemeyer, Franziska Neuser, Bernhard Lüscher, Jochen C Meier, Guenter Schwarz
Publikováno v:
PLoS Biology, Vol 12, Iss 7, p e1001908 (2014)
Postsynaptic scaffolding proteins regulate coordinated neurotransmission by anchoring and clustering receptors and adhesion molecules. Gephyrin is the major instructive molecule at inhibitory synapses, where it clusters glycine as well as major subse
Externí odkaz:
https://doaj.org/article/e6cf87bccb0541ceb1903100e4195d4e
Autor:
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D. Gandham, Christopher M. Rose, Corey E. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C. Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Nature Aging. 2:837-850
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependen
Autor:
Jiechao Zhou, Sarah D. Wade, David Graykowski, Mei-Fang Xiao, Binhui Zhao, Lucia A. A. Giannini, Jesse E. Hanson, John C. van Swieten, Morgan Sheng, Paul F. Worley, Borislav Dejanovic
Publikováno v:
Science Translational Medicine. 15(689)
Complement overactivation mediates microglial synapse elimination in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown. We identif
Autor:
Hu Zeng, Jiahao Huang, Haowen Zhou, William J. Meilandt, Borislav Dejanovic, Yiming Zhou, Christopher J. Bohlen, Seung-Hye Lee, Jingyi Ren, Albert Liu, Zefang Tang, Hao Sheng, Jia Liu, Morgan Sheng, Xiao Wang
Publikováno v:
Nature Neuroscience.
Autor:
Zohreh Farsi, Ally Nicolella, Sean K. Simmons, Sameer Aryal, Nate Shepard, Kira Brenner, Sherry Lin, Linnea Herzog, Wangyong Shin, Vahid Gazestani, Bryan Song, Kevin Bonanno, Hasmik Keshishian, Steven A. Carr, Evan Macosko, Sandeep Datta, Borislav Dejanovic, Eunjoon Kim, Joshua Z. Levin, Morgan Sheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b39ac0e3e8f874d530b13f1e86b50f
https://doi.org/10.2139/ssrn.4309117
https://doi.org/10.2139/ssrn.4309117