Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Boris Zinshteyn"'
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009813 (2021)
Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminatin
Externí odkaz:
https://doaj.org/article/fa5279b562774fcdb51142e48baba02b
Autor:
Niladri K Sinha, Alban Ordureau, Katharina Best, James A Saba, Boris Zinshteyn, Elayanambi Sundaramoorthy, Amit Fulzele, Danielle M Garshott, Timo Denk, Matthias Thoms, Joao A Paulo, J Wade Harper, Eric J Bennett, Roland Beckmann, Rachel Green
Publikováno v:
eLife, Vol 9 (2020)
Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to systematically
Externí odkaz:
https://doaj.org/article/900a514023304981b6374d2c536978ff
Autor:
Syed Usman Enam, Boris Zinshteyn, Daniel H Goldman, Madeline Cassani, Nathan M Livingston, Geraldine Seydoux, Rachel Green
Publikováno v:
eLife, Vol 9 (2020)
Puromycin is a tyrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypeptide chains from translating ribosomes. Puromycin has been used in molecular biology research for decades as a translation inhibitor. The developmen
Externí odkaz:
https://doaj.org/article/4f34ce7e063048d9bde53f7974f89f11
Autor:
Chad M. Kurylo, Matthew M. Parks, Manuel F. Juette, Boris Zinshteyn, Roger B. Altman, Jordana K. Thibado, C. Theresa Vincent, Scott C. Blanchard
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 236-248.e6 (2018)
Summary: Prevailing dogma holds that ribosomes are uniform in composition and function. Here, we show that nutrient limitation-induced stress in E. coli changes the relative expression of rDNA operons to alter the rRNA composition within the actively
Externí odkaz:
https://doaj.org/article/d3e78170d5eb4275abba28b85e6953b7
Autor:
Boris Zinshteyn, Wendy V Gilbert
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003675 (2013)
Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of translation in all organisms. The anticodon modification mcm(5)s(2)U(34) is required for normal growth and stress resistance in yeast; mutants lacking this modifica
Externí odkaz:
https://doaj.org/article/5848734c31b94514996c2795a9f43fd6
Autor:
Timm O. Koller, Ullrich Scheid, Teresa Kösel, Jennifer Herrmann, Daniel Krug, Helena I. M. Boshoff, Bertrand Beckert, Joanna C. Evans, Jan Schlemmer, Becky Sloan, Danielle M. Weiner, Laura E. Via, Atica Moosa, Thomas R. Ioerger, Michael Graf, Boris Zinshteyn, Maha Abdelshahid, Fabian Nguyen, Stefan Arenz, Franziska Gille, Maik Siebke, Tim Seedorf, Oliver Plettenburg, Rachel Green, Anna-Luisa Warnke, Joachim Ullrich, Ralf Warrass, Clifton E. Barry, Digby F. Warner, Valerie Mizrahi, Andreas Kirschning, Daniel N. Wilson, Rolf Müller
Publikováno v:
Journal of the American Chemical Society.
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be ex
Publikováno v:
RNA
Ribosome footprint profiling is a high-throughput sequencing–based technique that provides detailed and global views of translation in living cells. An essential part of this technology is removal of unwanted, normally very abundant, ribosomal RNA
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation
Publikováno v:
Cell Syst
Translational control shapes the proteome in normal and pathophysiological conditions. Current high-throughput approaches reveal large differences in mRNA-specific translation activity but cannot identify the causative mRNA features. We developed dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d896707277ba3aacd95643c4123cf985
https://europepmc.org/articles/PMC8930539/
https://europepmc.org/articles/PMC8930539/
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009813 (2021)
PLoS Genetics
PLoS Genetics
Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminatin
Autor:
Thomas M. Carlile, Wendy V. Gilbert, Tristan A Bell, Nicole M. Martinez, Boris Zinshteyn, Amanda Su, Cassandra Schaening
Publikováno v:
Nature chemical biology
Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions that affect gene expression. mRNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms re