Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Boris Z. Simkhovich"'
Publikováno v:
Cardiovascular Drugs and Therapy. 28:295-301
Topical capsaicin application was shown to reduce infarct size in experimental animal models. We hypothesized that cardioprotective properties of topical capsaicin application could be related to its hypothermic effect. In the first arm of the study,
Publikováno v:
Journal of Cardiovascular Electrophysiology. 23:1374-1383
Remote Ischemic Preconditioning and Cardiac Arrhythmias. Introduction: The effect of remote ischemic preconditioning (RIPC) on arrhythmias in in vivo models is unknown. Our purpose was to determine effects of both acute and delayed RIPC on arrhythmia
Autor:
Ruty Mehrian-Shai, Michael Mac Kinnon, Gang Feng, Paul Willet, Michael T. Kleinman, Boris Z. Simkhovich, Karina Salazar, Robert A. Kloner, Simon Lin, Ya-Hsuan Hsu, Glenn Gookin, Dianne Meacher
Publikováno v:
Air Quality, Atmosphere & Health. 4:15-25
Exposure to ambient particulate matter (PM) significantly increases cardiovascular morbidity and mortality in the general population. We hypothesized that some components of PM can affect the gene expression patterns in the hearts of rats exposed for
Autor:
Michael T. Kleinman, Andrew Keebaugh, Glenn Gookin, Boris Z. Simkhovich, Karina Salazar, Paul Willet, Robert A. Kloner
Publikováno v:
Air Quality, Atmosphere & Health. 4:27-36
Exposure to ambient particulate matter (PM) is linked to increases in cardiovascular morbidity and mortality. The exact mechanism by which PM induces cardiovascular toxicity is not completely understood. We sought to study histopathological changes i
Publikováno v:
Current Opinion in Cardiology. 24:604-609
Air pollution poses a significant health risk. The article focuses on the adverse effects of air pollution on the cardiovascular system.Short-term and long-term studies clearly indicate that relatively modest exposures to particulate matter in the am
Publikováno v:
Journal of the American College of Cardiology. 52:719-726
Recent epidemiologic studies show that increased levels of air pollutants are positively associated with cardiovascular morbidity and mortality. Inhalation of air pollutants affects heart rate, heart rate variability, blood pressure, vascular tone, b
Publikováno v:
Journal of Cardiovascular Pharmacology. 47:493-499
Mildronate is a fatty acid oxidation inhibitor approved as an antianginal drug in parts of Europe. We carried out the first study to determine whether a 10-day course of mildronate could reduce myocardial infarct size (IS) during acute myocardial isc
Autor:
Constantinos Sioutas, Loren E. Wold, Boris Z. Simkhovich, Robert A. Kloner, Michael T. Kleinman, Joan Dow, Margaret A. Nordlie
Publikováno v:
Cardiovascular Toxicology. 6:69-78
Exposure to ultrafine particles (UFPs) by inhalation increases the number and severity of cardiac events. The specific mechanism(s) of action are unknown. This study was designed to examine whether UFPs could exert a direct effect on the cardiovascul
Autor:
Tatsuya Iso, Robert A. Kloner, Coralie Poizat, Laurence Kedes, Kimi Y. Kong, Boris Z. Simkhovich, Yasuo Hamamori
Publikováno v:
Seminars in Nephrology. 24:437-440
Similar to the kidney in uremia, end-stage cardiac failure is an outcome common to many disparate disease processes including hypertension, various inflammatory pathologies, as well as ischemic loss of tissue. In regard to the heart, cellular and mol
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 9:83-90
Background: Our laboratory demonstrated that mild regional hypothermia reduced myocardial infarct size by an average of 65% in the rabbit model of regional ischemia. The exact mechanism for this benefit has not been explored. We hypothesized that a m