Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Boris V, Skryabin"'
Autor:
Franziska Werner, Estefania Prentki Santos, Konstanze Michel, Hanna Schrader, Katharina Völker, Tamara Potapenko, Lisa Krebes, Marco Abeßer, Dorothe Möllmann, Martin Schlattjan, Hannes Schmidt, Boris V. Skryabin, Katarina Špiranec Spes, Kai Schuh, Christopher P. Denton, Hideo A. Baba, Michaela Kuhn
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Excessive activation of cardiac fibroblasts (CFs) in response to injury provokes cardiac fibrosis, stiffness, and failure. The local mediators counterregulating this response remain unclear. Exogenous C-type natriuretic peptide (CNP) exerts antifibro
Externí odkaz:
https://doaj.org/article/7283f518feaf421cb1374fda596e995c
Autor:
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev
Publikováno v:
Cells, Vol 12, Iss 11, p 1543 (2023)
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isofo
Externí odkaz:
https://doaj.org/article/c301bbb2157d47f39041d05dc51f0267
Autor:
Nadja I. Bork, Anna Kuret, Melanie Cruz Santos, Cristina E. Molina, Beate Reiter, Hermann Reichenspurner, Andreas Friebe, Boris V. Skryabin, Timofey S. Rozhdestvensky, Michaela Kuhn, Robert Lukowski, Viacheslav O. Nikolaev
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102179- (2021)
3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many of which are associated with hypoxia. For example, in myocardial infarction and heart
Externí odkaz:
https://doaj.org/article/06f06ef82ac1467b9416c06fe88290d6
Autor:
Vladimir V. Matchkov, Henrik Black Joergensen, Dmitrii Kamaev, Andreas Hoegh Jensen, Hans Christian Beck, Boris V. Skryabin, Christian Aalkjaer
Publikováno v:
Physiological Reports, Vol 8, Iss 22, Pp n/a-n/a (2020)
Abstract A Ca2+‐activated Cl− channel protein, ANO1, is expressed in vascular smooth muscle cells where Cl− current is thought to potentiate contraction by contributing to membrane depolarization. However, there is an inconsistency between prev
Externí odkaz:
https://doaj.org/article/3e4d7138a8154e6db823e29a760b0017
Autor:
Konstanze Michel, Melissa Herwig, Franziska Werner, Katarina Špiranec Spes, Marco Abeßer, Kai Schuh, Swati Dabral, Andreas Mügge, Hideo A. Baba, Boris V. Skryabin, Nazha Hamdani, Michaela Kuhn
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility. The upstream pathways stimulating PKGI-mediated titin phosphorylati
Externí odkaz:
https://doaj.org/article/bc488a37aaa24a19ac2437a35f753e5f
Autor:
Toni Weinhage, Timo Wirth, Paula Schütz, Philipp Becker, Aloys Lueken, Boris V. Skryabin, Helmut Wittkowski, Dirk Foell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its role in acute
Externí odkaz:
https://doaj.org/article/d8837fd0bfc24332817bb5dad0e379c5
Autor:
Prabu Siva Sankar, Marimuthu Citartan, Aminah Ahmed Siti, Boris V. Skryabin, Timofey S. Rozhdestvensky, Goot Heah Khor, Thean Hock Tang
Publikováno v:
Iranian Journal of Microbiology, Vol 11, Iss 2 (2019)
Background and Objectives: Pfu DNA polymerase is an enzyme that exhibits the lowest error rate in the 3´ to 5´ exonuclease (proofreading) activity during DNA synthesis in Polymerase Chain Reactions (PCRs). This study was aimed to express and purify
Externí odkaz:
https://doaj.org/article/8c0f6334da53419cbf36a747f1cc7fec
Autor:
Nikolaev, Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O.
Publikováno v:
Cells; Volume 12; Issue 11; Pages: 1543
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a5d4791e9430863dccb40c6c37aaa8c2
Autor:
Aliska K. Brugmans, Carolin Walter, Natalia Moreno, Carolin Göbel, Dörthe Holdhof, Flavia W. de Faria, Marc Hotfilder, Daniela Jeising, Michael C. Frühwald, Boris V. Skryabin, Timofey S. Rozhdestvensky, Lydia Wachsmuth, Cornelius Faber, Martin Dugas, Julian Varghese, Ulrich Schüller, Thomas K. Albert, Kornelius Kerl
Publikováno v:
Cellular and Molecular Neurobiology.
The BAF (BRG1/BRM-associated factor) chromatin remodelling complex is essential for the regulation of DNA accessibility and gene expression during neuronal differentiation. Mutations of its core subunit SMARCB1 result in a broad spectrum of pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f431ab753ecc727dd8f6daa0fc8fb8e
https://doi.org/10.1007/s10571-023-01361-5
https://doi.org/10.1007/s10571-023-01361-5
Autor:
Dingding Mo, Xinping Li, Carsten A. Raabe, Timofey S. Rozhdestvensky, Boris V. Skryabin, Juergen Brosius
Publikováno v:
Cells, Vol 9, Iss 10, p 2196 (2020)
Alzheimer’s disease (AD) is an age-related detrimental dementia. Amyloid beta peptides (Aβ) play a crucial role in the pathology of AD. In familial AD, Aβ are generated from the full-length amyloid beta precursor protein (APP) via dysregulated pr
Externí odkaz:
https://doaj.org/article/43fd0b8b91f746e899bd068394eb13e4