Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Boris Sarvin"'
Autor:
Alon Stern, Mariam Fokra, Boris Sarvin, Ahmad Abed Alrahem, Won Dong Lee, Elina Aizenshtein, Nikita Sarvin, Tomer Shlomi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The inability to inspect metabolic activities within distinct subcellular compartments has been a major barrier to our understanding of eukaryotic cell metabolism. Previous work addressed this challenge by analyzing metabolism in isolated or
Externí odkaz:
https://doaj.org/article/98008274ca3d4b729756bb30a8190f9e
Autor:
Boris Sarvin, Shoval Lagziel, Nikita Sarvin, Dzmitry Mukha, Praveen Kumar, Elina Aizenshtein, Tomer Shlomi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Flow-injection mass spectrometry (FI-MS) enables high-throughput metabolomic profiling, but ion overload typically limits its sensitivity. Here, the authors show rapid and highly sensitive FI-MS overcoming an overload of the Orbitrap by analyzing sam
Externí odkaz:
https://doaj.org/article/c2489466f4664b04acf5985ee64b9758
Autor:
Shani Journo, Anat Klein Goldberg, Ethan S Sokol, Lotem Zinger, Metsada Pasmanik-Chor, Boris Sarvin, Dor Simkin, Sivan Fuchs, Tomer Shlomi, Ido Wolf, Tami Rubinek
Publikováno v:
Oncogene. 41:1468-1481
Metastases are often the direct cause of death from pancreatic ductal adenocarcinoma (PDAC). The role of genomic alterations (GA) in mediating tropism and metastasis formation by PDAC cells is currently unknown. We aimed to identify GAs predisposing
Autor:
Nina Mayorek, Miriam Schlossberg, Yousef Mansour, Nir Pillar, Ilan Stein, Fatima Mushasha, Guy Baziza, Eleonora Medvedev, Zakhariya Manevitch, Julia Menzel, Elina Aizenshtein, Boris Sarvin, Nikita Sarvin, Tomer Shlomi, Michael Klutstein, Eli Pikarsky
2-hydroxyglutarate (2HG) is recognized as an epigenetic regulator in cancer and some transient biological processes. Of all organs, the testis harbors the highest baseline physiological levels of 2HG, yet it’s putative functions in germ cell biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cda96a459f9166d8d00af93a72a17a65
https://doi.org/10.1101/2022.05.29.493890
https://doi.org/10.1101/2022.05.29.493890
Autor:
Dzmitry Mukha, Mariam Fokra, Alona Feldman, Boris Sarvin, Nikita Sarvin, Keren Nevo-Dinur, Elazar Besser, Elior Hallo, Elina Aizenshtein, Zachary T. Schug, Tomer Shlomi
Publikováno v:
Cell Metab
The folic acid cycle mediates the transfer of one-carbon (1C) units to support nucleotide biosynthesis. While the importance of serine as a mitochondrial and cytosolic donor of folate-mediated 1C units in cancer cells has been thoroughly investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e6106efeea8b2afa74a0158e1a5979
https://europepmc.org/articles/PMC9583459/
https://europepmc.org/articles/PMC9583459/
Autor:
Praveen Kumar, Shoval Lagziel, Tomer Shlomi, Boris Sarvin, Elina Aizenshtein, Dzmitry Mukha, Nikita Sarvin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Mass spectrometry based metabolomics is a widely used approach in biomedical research. However, current methods coupling mass spectrometry with chromatography are time-consuming and not suitable for high-throughput analysis of thousands of samples. A
Autor:
Boris Sarvin, Andrey Stavrianidi, Markus Himmelsbach, Oleg A. Shpigun, Wolfgang Buchberger, Igor Rodin, T. M. Baygildiev
Publikováno v:
Journal of Chromatography A. 1597:214-219
In this research an accumulation of nerve agent markers in garden cress (Lepidium sativum) as a model plant object was studied using LC-QTOF hybrid system. For the determination of methylphosphonic acid and alkyl methylphosphonates, which are specifi
Autor:
Andrey Stavrianidi, Vladimir V. Kuznetsov, Ilya E. Zlobin, Alexander V. Kartashov, Boris Sarvin, Yury V. Ivanov
Publikováno v:
Environmental and Experimental Botany. 157:151-160
Sugars, sugar alcohols and starch are the main components of the mobile carbon pool in plants. Water stress substantially affects the carbon balance in plants and the reserves of mobile carbon and can lead to their exhaustion and the development of c
Publikováno v:
Journal of Chromatography B. 1092:138-144
The ultrasound-assisted extraction method for isolation of 17 sugars and sugar alcohols from conifers with a subsequent hydrophilic interaction liquid chromatography-tandem mass spectrometry method for their determination is proposed. The optimizatio
Autor:
Nikita Sarvin, Shachar Raz, Shoval Lagziel, Elina Aizenshtein, Won Dong Lee, Dzmitry Mukha, Keren Nevo-Dinur, Tomer Shlomi, Anna Chiara Pirona, Elazar Besser, Boris Sarvin, Alon Stern
Publikováno v:
Cell metabolism. 33(1)
Summary Folate metabolism supplies one-carbon (1C) units for biosynthesis and methylation and has long been a target for cancer chemotherapy. Mitochondrial serine catabolism is considered the sole contributor of folate-mediated 1C units in proliferat