Výsledky vyhledávání - "Boris P. Kopnin"

Significance of NOTCH1 Expression in the Progression of Human Lung and Colorectal Cancers

Autor: Maria V. Vasileva, Natalia V. Khromova, Boris P. Kopnin, Vera B. Dugina, Pavel B. Kopnin

Publikováno v: Biochemistry (Moscow). 87:1199-1205

Lung and colorectal cancers are the most common types of cancer characterized by a poor prognosis and a high mortality rate. Mutations in the genes encoding components of the main intra- and extracellular signaling pathways, in particular the NOTCH1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e7151c233c278f425163702f8c81f9
https://doi.org/10.1134/s0006297922100133

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Data from Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

Autor: Peter M. Chumakov, Boris P. Kopnin, Larissa S. Agapova, Pavel B. Kopnin

Oncogenic mutations within RAS genes and inactivation of p53 are the most common events in cancer. Earlier, we reported that activated Ras contributes to chromosome instability, especially in p53-deficient cells. Here we show that an increase in intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60eb5080becc63b123b81e9e211649ea
https://doi.org/10.1158/0008-5472.c.6494789

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Supplementary Figures 1-2 from Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

Autor: Peter M. Chumakov, Boris P. Kopnin, Larissa S. Agapova, Pavel B. Kopnin

Supplementary Figures 1-2 from Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3810f899a0e77ab813d54bef677c20f3
https://doi.org/10.1158/0008-5472.22365629.v1

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71P Breast cancer cells’ taxol-resistance is associated with cytoplasmic actin isoforms balance shift and acquisition of more malignant phenotype

Autor: Vera Dugina, P.B. Kopnin, Sergei Boichuk, M.V. Novikova, Boris P. Kopnin

Publikováno v: Annals of Oncology. 32:S1367

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::035d5ba2a29bccc782e5716be32ee815
https://doi.org/10.1016/j.annonc.2021.08.2067

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E-CADHERIN EXPRESSION DOWNREGULATION ELEVATES TUMOROGENIC POTENTIAL OF HUMAN COLON CANCER CELL LINE HCT116 VIA INCREASE IN CANCER STEM CELLS AMOUNT

Autor: Pavel Kopnin, N. V. Khromova, Boris P. Kopnin, M. D. Farmakovskaya

Publikováno v: Russian Journal of Biotherapy. 15:6-14

Introduction. E-cadherin aberrant expression or complete loss is common for a number of human malignant neoplasms, and can be a launching mechanism of an epithelial-mesenchymal transition. Passing through epithelial-mesenchymal transition could in tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f7da1f0b7e64bfe41568103b158e8f1
https://doi.org/10.17650/1726-9784-2016-15-3-06-14

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62P Cytoplasmic actin isoforms influence on CSC-like properties

Autor: Boris P. Kopnin, O. Sokova, P. Kopnin, Vera Dugina, M.V. Novikova

Publikováno v: Annals of Oncology. 31:S1236

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a92d74a38df36e5c523d07239a09df8a
https://doi.org/10.1016/j.annonc.2020.08.2221

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64P Notch- and P53-dependent crosstalk between tumour and stromal cells

Autor: Vera Dugina, Boris P. Kopnin, M.V. Novikova, P. Kopnin, N. Khromova

Publikováno v: Annals of Oncology. 31:S1236

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83749a7d5106db4ca53a28644c43a929
https://doi.org/10.1016/j.annonc.2020.08.2223

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E-Cadherin repression increases amount of cancer stem cells in human A549 lung adenocarcinoma and stimulates tumor growth

Autor: N. V. Khromova, Vera A. Rybko, Boris P. Kopnin, Vera Dugina, Pavel Kopnin, M. Farmakovskaya

Publikováno v: Cell cycle (Georgetown, Tex.). 15(8)

Here we show that cancer stem cells amount in human lung adenocarcinoma cell line A549 depends on E-cadherin expression. In fact, downregulation of E-cadherin expression enhanced expression of pluripotent genes (c-MYC, NESTIN, OCT3/4 and SOX2) and en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6327911b2bdeac075fc9fadfa9450238
https://pubmed.ncbi.nlm.nih.gov/26940223

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PO-081 Notch signalling pathway plays a crucial role in maintaining the cancer stem cell population in lung and colorectal cancer

Autor: Pavel Kopnin, Vera A. Rybko, Boris P. Kopnin, Maria Novikova, N. V. Khromova, Vera Dugina

Publikováno v: ESMO Open. 3:A52-A53

Introduction There is increasing evidence that cancer stem cells (CSCs) could mediate resistance to chemo- and radiotherapy, metastasis and recurrence in a wide range of solid tumours. Notch signalling pathway is involved in CSCs maintenance. Notch i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9958e9fcf7b41d023d24dc44c48eedc5
https://doi.org/10.1136/esmoopen-2018-eacr25.124

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PO-267 Notch-dependent tumourigenic mechanism associated with exosome signalling

Autor: Boris P. Kopnin, Pavel Kopnin, Vera A. Rybko, N. V. Khromova, Maria Novikova

Publikováno v: ESMO Open. 3:A331-A332

Introduction Tumour microenvironment (TME) plays a crucial role in tumours initiation, progression and response to therapy. It is becoming increasingly clear that one of the most important promoters of tumour growth and progression is a subpopulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f47dfca711ae5c5c50c0dea92336ff90
https://doi.org/10.1136/esmoopen-2018-eacr25.781

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