Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Boris Kysela"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Cancer is a significant and constantly growing clinical problem all over the word. For many types of cancer there has been little change in mortality rate of CRC in the past decades and treatment options are limited. A striking example is malignant G
Externí odkaz:
https://doaj.org/article/a32e4e8857124526a153f5f7ff603612
Publikováno v:
Neoplasma. 65:708-719
Ku70 protein in hetero-trimeric complex with Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) represents a critical component of the nonhomologous-end-joining (NHEJ), the major machinery of DSBs repair in mammalian cells. It has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb30bb46911973a077e4ca20a268dd53
https://doi.org/10.4149/neo_2018_171020n673
https://doi.org/10.4149/neo_2018_171020n673
Autor:
Richard I. Tuxworth, Ane Martin Anduaga, Alaa Hussien-Ali, Matthew J. Taylor, Adam M. Thompson, Sotiroula Chatzimatthaiou, Pavlos Alifragis, Boris Kysela, Charalambos P. Kyriacou, Joanne Longland, Sharif Almutiri, Zubair Ahmed
Publikováno v:
Brain Communications
DNA double strand breaks feature in neurological disorders, including many forms of neurodegeneration, stroke and acute neurotrauma. Tuxworth et al. show that inhibiting the DNA damage sensing response is neuroprotective, axon regenerative and improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8793ed66e866197b36212fff03d339e7
https://doi.org/10.1093/braincomms/fcz005
https://doi.org/10.1093/braincomms/fcz005
Autor:
Ane Martin Anduaga, Richard I. Tuxworth, Matthew J. Taylor, Sharif Almutiri, Zubair Ahmed, Joanne Longland, Boris Kysela, Charalambos P. Kyriacou, Alaa Hussien-Ali, Pavlos Alifragis, Sotiroula Chatzimatthaiou, Adam M. Thompson
Publikováno v:
Brain Communications
DNA double-strand breaks are a feature of many acute and long-term neurological disorders, including neurodegeneration, following neurotrauma and after stroke. Persistent activation of the DNA damage response in response to double strand breaks contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494691945f17eac4a954807c7415f34f
https://doi.org/10.1101/440636
https://doi.org/10.1101/440636
Autor:
Valérie Cormier-Daire, Hanna IJspeert, Boris Kysela, Grant S. Stewart, Marco Cappa, Gail E. Graham, Mirjam van der Burg, Louise S. Bicknell, Francesco Brancati, Armand Bottani, Eissa Faqeih, Jennie E. Murray, Takashi Ochi, Emmanuelle Ranza, Alireza Jawad, Tom L. Blundell, Edward S. Miller, Andrew P. Jackson, Andrea Leitch, Charu Deshpande, Qian Wu, Paula Carroll
Publikováno v:
American Journal of Human Genetics, 96(3), 412-424. Cell Press
Non-homologous end joining (NHEJ) is a key cellular process ensuring genome integrity. Mutations in several components of the NHEJ pathway have been identified, often associated with severe combined immunodeficiency (SCID), consistent with the requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f25ebd09a7eb0552c5841786343d5d
https://doi.org/10.1016/j.ajhg.2015.01.013
https://doi.org/10.1016/j.ajhg.2015.01.013
Autor:
Heather Beamish, P. A. Jeggo, Tracy Blunt, Boris Kysela, Anne Priestley, Enriqueta Riballo, R. Jessberger
DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase (DNA-PK), has a phosphoinositol 3-kinase (PI 3-K) domain close to its C-terminus. Cell lines derived from the SCID mouse have been utilised as a model DNA-PKcs-defective system. The SCID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8087ed65820fb4d4db8f7ec09333168
http://doc.rero.ch/record/304425/files/gkd266.pdf
http://doc.rero.ch/record/304425/files/gkd266.pdf
Publikováno v:
Proceedings of the National Academy of Sciences. 102:1877-1882
DNA nonhomologous end-joining in vivo requires the DNA-dependent protein kinase (DNA-PK) and DNA ligase IV/XRCC4 (LX) complexes. Here, we have examined the impact of histone octamers and linker histone H1 on DNA end-joining in vitro . Packing of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65aa9e949298c30c4c32f3da001b5de1
https://doi.org/10.1073/pnas.0401179102
https://doi.org/10.1073/pnas.0401179102
Autor:
Boris Kysela, Céline Baldeyron, Penny A. Jeggo, Kostas G. Manolis, Michael R. Lieber, Julianne Smith, Dora Papadopoulo, Enriqueta Riballo, Christel Masson
Publikováno v:
Nucleic Acids Research. 31:2157-2167
A DNA ligase IV (LIG4)‐null human pre‐B cell line and human cell lines with hypomorphic mutations in LIG4 are significantly impaired in the frequency and fidelity of end joining using an in vivo plasmid assay. Analysis of the null line demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5243fa51816b0472aeeb98b64fab6eae
https://doi.org/10.1093/nar/gkg317
https://doi.org/10.1093/nar/gkg317
Autor:
Kostas G. Manolis, T. O. Harville, Penny A. Jeggo, Yan Dai, L. A. Hanakahi, Boris Kysela, Markus Stumm, Stephen C. West, Enriqueta Riballo, Marjorie A. Oettinger
Publikováno v:
Proceedings of the National Academy of Sciences. 100:2462-2467
DNA nonhomologous end-joining (NHEJ) is the major pathway for repairing DNA double-strand breaks in mammalian cells. It also functions to carry out rearrangements at the specialized breaks introduced during V(D)J recombination. Here, we describe a pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df5a589476e6af60519169d07007f25
https://doi.org/10.1073/pnas.0437964100
https://doi.org/10.1073/pnas.0437964100
Autor:
Kevin M. Devine, Aidan J. Doherty, Elizabeth Scanlan, Stephen P. Jackson, Geoffrey R. Weller, Adam Wilkinson, Marina Della, Boris Kysela, Susanne Krogh Devine, Richard P. Bowater, Louise M. Tonkin, Jonathan P. Day, Rajat Roy, Fabrizio d'Adda di Fagagna, Penny A. Jeggo
Publikováno v:
Science. 297:1686-1689
In eukaryotic cells, double-strand breaks (DSBs) in DNA are generally repaired by the pathway of homologous recombination or by DNA nonhomologous end joining (NHEJ). Both pathways have been highly conserved throughout eukaryotic evolution, but no equ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a82ed73af1050cd9eca2d18a07eeaaf
https://doi.org/10.1126/science.1074584
https://doi.org/10.1126/science.1074584