Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Boris Klebansky"'
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 597 (2024)
Current anti-cancer immune checkpoint therapy relies on antibodies that primarily target the PD-1/PD-L1(-L2) negative regulatory pathway. Although very successful in some cases for certain cancers, these antibodies do not help most patients who, pres
Externí odkaz:
https://doaj.org/article/10b1e02d1e2c450a9aabe5d4b701fa26
Autor:
Matthew Gibbs, Marcel Winnig, Irene Riva, Nicola Dunlop, Daniel Waller, Boris Klebansky, Darren W Logan, Stephen J Briddon, Nicholas D Holliday, Scott J McGrane
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277607 (2022)
As the most favoured animal companion of humans, dogs occupy a unique place in society. Understanding the senses of the dog can bring benefits to both the dogs themselves and their owners. In the case of bitter taste, research may provide useful info
Externí odkaz:
https://doaj.org/article/c4168cb992604476a8d28af15dfe6e90
Autor:
Richard E. Fine, Lidia Sambucetti, Peter D. Hobbs, Joy M. Calaoagan, Barbara G. Sato, Sarah J. Duellman, Keith R. Laderoute, Wan-Ru Chao, Boris Klebansky, Nathan Collins
Publikováno v:
Biochemical Pharmacology. 80:819-826
The orphan nuclear receptor estrogen-related receptor α (ERRα) has been implicated in the development of various human malignancies, including breast, prostate, ovary, and colon cancer. ERRα, bound to a co-activator protein (e.g., peroxisome proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af311192b05c78c3343a63e60fd0b1c
https://doi.org/10.1016/j.bcp.2010.05.024
https://doi.org/10.1016/j.bcp.2010.05.024
Autor:
Chi Ching Mak, Xianchang Gong, Elena Dneprovskaia, Andrew McPherson, Ved P. Pathak, J. Hood, Binqi Zeng, Boris Klebansky, Richard M. Fine, W. Liao, Wolfgang Wrasidlo, Glenn Noronha, Joel Renick, Ningning Zhao, Y. Zhou, Kathy Barrett, Colleen Gritzen, Moorthy S. S. Palanki, Xinshan Kang, Ge Li, Ute Splittgerber, Richard M. Soll, Daniel L. Lohse, Jianguo Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5546-5550
We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c3a59d9d64cb5d6108ec85b738a7b4
https://doi.org/10.1016/j.bmcl.2006.08.035
https://doi.org/10.1016/j.bmcl.2006.08.035
Autor:
Glen Noronha, Jianguo Cao, Chun Chow, Elena Dneprovskaia, Linda Hwang, Dan Lohse, Chi Ching Mak, Andrew McPherson, Richard M. Fine, Xinshan Kang, Boris Klebansky, Moorthy S.S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d4f3146de588732bf746c8ec5d69ab
https://doi.org/10.2174/978160805201110703010121
https://doi.org/10.2174/978160805201110703010121
Autor:
Guy Servant, Haitian Liu, Catherine Tachdjian, Feng Zhang, Hong Xu, Boris Klebansky, Richard M. Fine, Mark Zoller, Xiaodong Li
Positive allosteric modulators of the human sweet taste receptor have been developed as a new way of reducing dietary sugar intake. Besides their potential health benefit, the sweet taste enhancers are also valuable tool molecules to study the genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff1393eed61ca40fee59198226f5c27
https://europepmc.org/articles/PMC2842058/
https://europepmc.org/articles/PMC2842058/
Autor:
Feng Zhang, Hong Xu, Xiaodong Li, Haitian Liu, Catherine Tachdjian, Alexey Pronin, Boris Klebansky, Richard M. Fine
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(52)
Umami is one of the 5 basic taste qualities. The umami taste of L-glutamate can be drastically enhanced by 5′ ribonucleotides and the synergy is a hallmark of this taste quality. The umami taste receptor is a heteromeric complex of 2 class C G-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90f3d91bfeaf6908297a96d842abcab
https://pubmed.ncbi.nlm.nih.gov/19104071
https://pubmed.ncbi.nlm.nih.gov/19104071
Autor:
Elena Dneprovskaia, Daniel L. Lohse, Richard Soll, Andrew McPherson, Chi Ching Mak, John Hood, Boris Klebansky, Richard M. Fine, Joel Renick, Jianguo Cao, Chun P. Chow, Moorthy S. S. Palanki, Glenn Noronha, Ved P. Pathak, Binqi Zeng, Xinshan Kang
Publikováno v:
Current topics in medicinal chemistry. 8(10)
Chronic myelogenous leukemia (CML) is a hematological stem cell disorder caused by increased and unregulated growth of myeloid cells in the bone marrow, and the accumulation of excessive white blood cells. Abelson tyrosine kinase (ABL) is a non-recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12165fa94b4010e1abb10fefa72becb6
https://pubmed.ncbi.nlm.nih.gov/18673174
https://pubmed.ncbi.nlm.nih.gov/18673174
Autor:
Ved P. Pathak, Chun P. Chow, Shiyin Yee, Michael D. Martin, Binqi Zeng, Hong Zhu, Shu Kachi, John Doukas, Naoyasu Umeda, Andrew McPherson, Dellamary Luis A, Hideo Akiyama, J. Hood, Boris Klebansky, Moorthy S.S. Palanki, Richard M. Fine, Katsutoshi Yokoi, Peter A. Campochiaro, Ahmed A Kousba, Joel Renick, Glenn Noronha, Dan Lohse, Xinshan Kang, Richard M. Soll, Colleen Gritzen, Chi Ching Mak, Steven Hu, Jianguo Cao
Publikováno v:
Journal of medicinal chemistry. 51(6)
Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to treat AMD has been validated clinically. A large body of evidence suggests that inhibitors ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60c2e3e531b4630c43bbf6701bffacd
https://pubmed.ncbi.nlm.nih.gov/18311895
https://pubmed.ncbi.nlm.nih.gov/18311895
Autor:
Chi Ching Mak, Richard E. Fine, Andrew McPherson, John Hood, Daniel L. Lohse, Moorthy S. S. Palanki, Xinshan Kang, Colleen Gritzen, Boris Klebansky, Ved P. Pathak, Joel Renick, Richard Soll, Jianguo Cao, Binqi Zeng, Hong Zhu, Glenn Noronha
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
We describe the design, synthesis and structure-activity relationship studies in optimizing a series of benzotriazine compounds as potent inhibitors of both Abl and Abl-T315I enzymes. The design includes targeting of an acid functional residue on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9487248cf8bfc4677744d54717e2e8d8
https://pubmed.ncbi.nlm.nih.gov/17827012
https://pubmed.ncbi.nlm.nih.gov/17827012