Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Boris Kantor"'
Autor:
Boris Kantor, Bernadette O’Donovan, Joseph Rittiner, Dellila Hodgson, Nicholas Lindner, Sophia Guerrero, Wendy Dong, Austin Zhang, Ornit Chiba-Falek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Safely and efficiently controlling gene expression is a long-standing goal of biomedical research, and CRISPR/Cas system can be harnessed to create powerful tools for epigenetic editing. Adeno-associated-viruses (AAVs) represent the delivery
Externí odkaz:
https://doaj.org/article/d740925713534bfe9a186ede159412a0
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102084- (2024)
Overexpression of SNCA has been implicated in the pathogenesis of synucleinopathies, particularly Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). While PD and DLB share some clinical and pathological similarities, each disease present
Externí odkaz:
https://doaj.org/article/a9ee28d40a73477abb5a6c1f09997ea4
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Epigenetic dysregulation is an important determinant of many pathological conditions and diseases. Designer molecules that can specifically target endogenous DNA sequences provide a means to therapeutically modulate gene function. The prokaryote-deri
Externí odkaz:
https://doaj.org/article/89557838df4841e4825115c9d5a7344c
Autor:
Jeffrey Gu, Julio Barrera, Young Yun, Susan K. Murphy, Thomas G. Beach, Randy L. Woltjer, Geidy E. Serrano, Boris Kantor, Ornit Chiba-Falek
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Parkinson’s disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. SNCA gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies o
Externí odkaz:
https://doaj.org/article/ef6ea94f3e824e5c94102fc7c3ebdfe6
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100152- (2020)
Summary: Lentiviral vectors are an ideal gene-delivery system for large gene-editing tools, such as the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system, due to their high packaging capacity and broad tropism. Here, we pr
Externí odkaz:
https://doaj.org/article/2cca949c819847798746c7ef39a9edbb
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Diseases of the central nervous system (CNS) have historically been among the most difficult to treat using conventional pharmacological approaches. This is due to a confluence of factors, including the limited regenerative capacity and overall compl
Externí odkaz:
https://doaj.org/article/6ae33d433b594eb2ab84c560caef3533
Autor:
Wendy Dong, Boris Kantor
Publikováno v:
Viruses, Vol 13, Iss 7, p 1288 (2021)
CRISPR/Cas technology has revolutionized the fields of the genome- and epigenome-editing by supplying unparalleled control over genomic sequences and expression. Lentiviral vector (LV) systems are one of the main delivery vehicles for the CRISPR/Cas
Externí odkaz:
https://doaj.org/article/5b2753024f3645e08eb2faa330a2c70b
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 153-164 (2017)
The CRISPR/Cas9 systems have revolutionized the field of genome editing by providing unprecedented control over gene sequences and gene expression in many species, including humans. Lentiviral vectors (LVs) are one of the primary delivery platforms f
Externí odkaz:
https://doaj.org/article/83c2fd577b794d9585b86f6fd00e7f20
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1244 (2021)
Alzheimer’s disease (AD) has a critical unmet medical need. The consensus around the amyloid cascade hypothesis has been guiding pre-clinical and clinical research to focus mainly on targeting beta-amyloid for treating AD. Nevertheless, the vast ma
Externí odkaz:
https://doaj.org/article/c33174fe142948c8966ba6e337f1453d
Autor:
Mark A Titus, Brian Zeithaml, Boris Kantor, Xiangping Li, Karin Haack, Dominic T Moore, Elizabeth M Wilson, James L Mohler, Tal Kafri
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30192 (2012)
Prostate cancer (CaP) is the second leading cause of cancer death in American men. Androgen deprivation therapy is initially effective in CaP treatment, but CaP recurs despite castrate levels of circulating androgen. Continued expression of the andro
Externí odkaz:
https://doaj.org/article/acd202f4d611417ca97fd015a69978d3