Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy.

Autor: Michelle Spaan, Sebastiaan J Hullegie, Boris J B Beudeker, Kim Kreefft, Gertine W van Oord, Zwier M A Groothuismink, Marjolein van Tilborg, Bart Rijnders, Robert J de Knegt, Mark A A Claassen, Andre Boonstra

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159243 (2016)

Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and fun

Externí odkaz: https://doaj.org/article/ceeec7d7dbc8492488ce103792aa7e08

Circulating biomarkers for early detection of hepatocellular carcinoma

Autor: Boris J. B. Beudeker, Andre Boonstra

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 13 (2020)

Hepatocellular carcinoma (HCC) is estimated to be the fourth leading cause of cancer-related deaths worldwide. HCC patients face a dismal prognosis because symptoms usually appear in an advanced stage of disease. The detection of early stage HCC allo

Externí odkaz: https://doaj.org/article/ed0d85501a764cc0a702b73eb6b3c2f0

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

Autor: Gertine W. van Oord, Jasmin Joseph-Chazan, Raymond T. Chung, Jordan J. Feld, Juan D. Sanchez Vasquez, Chris Oetheimer, Martin Arreola Villanueva, Ira Fleming, Nir Hacohen, Alex S. Genshaft, Georg M. Lauer, Nancy Tran, Sonu Subudhi, Alex K. Shalek, Jacques Bollekens, Lauke L. Boeijen, Nadia Conceição-Neto, Aman Mehrotra, Adam J. Gehring, Nadia Alatrakchi, Arlin Keo, Constantine Tzouanas, Boris J. B. Beudeker, Zgjim Osmani, Robert J. de Knegt, Mike Vilme, Jeroen Aerssens, Harmen J.G. van de Werken, Harry L.A. Janssen, Shirin Nkongolo, Deeqa Mahamed, Andre Boonstra, Zwier M. A. Groothuismink, Riley Drake

Blood samples are frequently collected in human studies of the immune system but poorly represent tissue-resident immunity. Understanding the immunopathogenesis of tissue-restricted diseases, such as chronic hepatitis B, necessitates direct investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e22266594a757319da157dc9cd79ba9a
https://doi.org/10.1101/2021.11.30.470634

Prevalence of hepatitis delta virus among chronic hepatitis B carriers in a large tertiary center in the Netherlands

Autor: Boris J. B. Beudeker, Corine H. GeurtsvanKessel, Annemiek A. van der Eijk, Jolanda J.C. Voermans, Tamara Kuhlemann, Andre Boonstra, Robert J. de Knegt

Publikováno v: Journal of Clinical Virology
Journal of Clinical Virology, 141:104870. Elsevier

Background & aims Hepatitis D virus infection (HDV) is considered the most severe form of viral hepatitis. In this study, we aimed to evaluate the prevalence of HDV infection in a tertiary center of a large, multi-ethnic city in the Netherlands. More

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8720034e7b149d77f8e16edb0cb3897f

Circulating biomarkers for early detection of hepatocellular carcinoma

Autor: Andre Boonstra, Boris J. B. Beudeker

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 13 (2020)
Therapeutic Advances in Gastroenterology
Therapeutic Advances in Gastroenterology, 13. SAGE Publications Ltd

Hepatocellular carcinoma (HCC) is estimated to be the fourth leading cause of cancer-related deaths worldwide. HCC patients face a dismal prognosis because symptoms usually appear in an advanced stage of disease. The detection of early stage HCC allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc98dca2dede52d0a0f6090162e5dedd
https://pure.eur.nl/en/publications/a227f577-ac09-44c2-905d-57c039952326