Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Boris I. RATNIKOV"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008101 (2021)
Proteases are an important class of enzymes, whose activity is central to many physiologic and pathologic processes. Detailed knowledge of protease specificity is key to understanding their function. Although many methods have been developed to profi
Externí odkaz:
https://doaj.org/article/d3cb82b7268547169dae5205c45e6cdd
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127877 (2015)
CleavPredict (http://cleavpredict.sanfordburnham.org) is a Web server for substrate cleavage prediction for matrix metalloproteinases (MMPs). It is intended as a computational platform aiding the scientific community in reasoning about proteolytic ev
Externí odkaz:
https://doaj.org/article/49c3fe72c6144da4b4f863a1ca9e968b
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131952 (2015)
Externí odkaz:
https://doaj.org/article/004f6eb158d441d391ec694a13228b92
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008101 (2021)
PLoS Computational Biology
PLoS Computational Biology
Proteases are an important class of enzymes, whose activity is central to many physiologic and pathologic processes. Detailed knowledge of protease specificity is key to understanding their function. Although many methods have been developed to profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169221cf601b5e57806ed8c09b6a052f
https://doi.org/10.1101/2020.06.30.179820
https://doi.org/10.1101/2020.06.30.179820
Autor:
Sergey A Shiryaev, Alexei Y Savinov, Piotr Cieplak, Boris I Ratnikov, Khatereh Motamedchaboki, Jeffrey W Smith, Alex Y Strongin
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4952 (2009)
Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The classic MBP isoforms
Externí odkaz:
https://doaj.org/article/bbd584347aae4faf9ca8cda3726db973
Autor:
Andrei L. Osterman, Boris I. Ratnikov, Jeffrey W. Smith, David A. Scott, Pedro Aza-Blanc, Ze'ev Ronai
Publikováno v:
Oncotarget
// Boris Ratnikov 1 , Pedro Aza-Blanc 1 , Ze’ev A. Ronai 1 , Jeffrey W. Smith 1 , Andrei L. Osterman 1 , David A. Scott 1 1 Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA Correspondence to: Andrei L. Osterman, e-mail: o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3feb7b0a173a7a4b1ad3d3e214b353a
https://doi.org/10.18632/oncotarget.3132
https://doi.org/10.18632/oncotarget.3132
Autor:
Gennady V. Ponomarev, Mikhail S. Gelfand, Piotr Cieplak, Gennady G. Fedonin, Evgenii V. Matveev, Marat D. Kazanov, Boris I. Ratnikov, Alexey Eroshkin
Publikováno v:
Biochim Biophys Acta Proteins Proteom
Bioinformatics-based prediction of protease substrates can help to elucidate regulatory proteolytic pathways that control a broad range of biological processes such as apoptosis and blood coagulation. The majority of published predictive models are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e931892da21cf4a521b00fa827afc8
https://doi.org/10.1016/j.bbapap.2019.07.006
https://doi.org/10.1016/j.bbapap.2019.07.006
Publikováno v:
Oncoscience
Recent studies highlight the importance of glutamine metabolism in metabolic reprogramming, which underlies cancer cell addiction to glutamine. Examples for the dependence on glutamine metabolism are seen across different tumor types as during differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db95489f3ece7d6196edd01b245538d6
http://europepmc.org/articles/PMC4580059
http://europepmc.org/articles/PMC4580059
Autor:
Andrei L. Osterman, Jeffrey W. Smith, Boris I. Ratnikov, David A. Scott, Fabian V. Filipp, Jessica De Ingeniis
Publikováno v:
Pigment Cell & Melanoma Research. 25:732-739
In this perspective, we revise the historic notion that cancer is a disease of mitochondria. We summarize recent findings on the function and rewiring of central carbon metabolism in melanoma. Metabolic profiling studies using stable isotope tracers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::908c2a86c3f951414d3bc5daac6eb8cc
https://doi.org/10.1111/pcmr.12000
https://doi.org/10.1111/pcmr.12000
Autor:
Piotr Cieplak, Alexey Eroshkin, Andrei L. Osterman, Jeffrey W. Smith, Adam Godzik, Zhanwen Li, Boris I. Ratnikov, Marat D. Kazanov, Yoshinobu Igarashi, Ying Zhang
Publikováno v:
Journal of Proteome Research. 10:3642-3651
Limited or regulatory proteolysis plays a critical role in many important biological pathways like blood coagulation, cell proliferation, and apoptosis. A better understanding of mechanisms that control this process is required for discovering new pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01051c05493ca0890610edc531160402
https://doi.org/10.1021/pr200271w
https://doi.org/10.1021/pr200271w