Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Boris I Shraiman"'
Autor:
Noah P Mitchell, Dillon J Cislo, Suraj Shankar, Yuzheng Lin, Boris I Shraiman, Sebastian J Streichan
Publikováno v:
eLife, Vol 11 (2022)
Organ architecture is often composed of multiple laminar tissues arranged in concentric layers. During morphogenesis, the initial geometry of visceral organs undergoes a sequence of folding, adopting a complex shape that is vital for function. Geneti
Externí odkaz:
https://doaj.org/article/f09c7a41efc14ef283cc4d865938d3b1
Publikováno v:
eLife, Vol 8 (2019)
Rapidly evolving pathogens like influenza viruses can persist by changing their antigenic properties fast enough to evade the adaptive immunity, yet they rarely split into diverging lineages. By mapping the multi-strain Susceptible-Infected-Recovered
Externí odkaz:
https://doaj.org/article/3d5966f553df40c2a07d5612b722d5c8
Publikováno v:
eLife, Vol 7 (2018)
During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding into specific shapes. While developmental biology has identified key genes and local cellular processes, global coordination of tissue remodeling at the organ scale
Externí odkaz:
https://doaj.org/article/808e6457005543f7bf13854d34731e01
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 9, Pp 1827-1835 (2007)
Polyketides, a diverse group of heteropolymers with antibiotic and antitumor properties, are assembled in bacteria by multiprotein chains of modular polyketide synthase (PKS) proteins. Specific protein-protein interactions determine the order of prot
Externí odkaz:
https://doaj.org/article/fc8e398f599c444a8455be808654d6e4
Publikováno v:
eLife, Vol 3 (2014)
Given a sample of genome sequences from an asexual population, can one predict its evolutionary future? Here we demonstrate that the branching patterns of reconstructed genealogical trees contains information about the relative fitness of the sampled
Externí odkaz:
https://doaj.org/article/fa4a2ff954b144ccb898ac615fa78d46
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 5, p e1002512 (2012)
Many morphogenetic processes involve mechanical rearrangements of epithelial tissues that are driven by precisely regulated cytoskeletal forces and cell adhesion. The mechanical state of the cell and intercellular adhesion are not only the targets of
Externí odkaz:
https://doaj.org/article/f60151361d0547c191c4c8b17556fed2
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001315 (2011)
Here we investigate the correlations between coding sequence substitutions as a function of their separation along the protein sequence. We consider both substitutions between the reference genomes of several Drosophilids as well as polymorphisms in
Externí odkaz:
https://doaj.org/article/b12e19aff3884b7a8066f88b9f55e3f7
Autor:
Yoram Burak, Boris I Shraiman
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 12, p e1000628 (2009)
Cells in the wing blade of Drosophila melanogaster exhibit an in-plane polarization causing distal orientation of hairs. Establishment of the Planar Cell Polarity (PCP) involves intercellular interactions as well as a global orienting signal. Many of
Externí odkaz:
https://doaj.org/article/789d967bb17746fcb64d42595a1021cc
Publikováno v:
bioRxiv
Shape changes of epithelia during animal development, such as convergent extension, are achieved through concerted mechanical activity of individual cells. While much is known about the corresponding large scale tissue flow and its genetic drivers, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3a6054ecfbdd306cc18d9fbe468f98
https://europepmc.org/articles/PMC10312603/
https://europepmc.org/articles/PMC10312603/
Publikováno v:
Physical Review X, Vol 10, Iss 1, p 011072 (2020)
Cellular mechanics drives epithelial morphogenesis, the process wherein cells collectively rearrange to produce tissue-scale deformations that determine organismal shape. However, quantitative understanding of tissue mechanics is impaired by the diff
Externí odkaz:
https://doaj.org/article/d5d5d3216ced40f186fa87ddb57e5a6c