Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Boris G Wilson"'
Publikováno v:
eLife, Vol 4 (2015)
ISWI family chromatin remodelers typically organize nucleosome arrays, while SWI/SNF family remodelers (RSC) typically disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivo. Here, we describe two independent gen
Externí odkaz:
https://doaj.org/article/d3b2e526e71741b5a4fbe3148eadee59
Autor:
Xiaofeng Wang, Adrianna K. San Roman, Burak H. Alver, Charles W. M. Roberts, Agoston T. Agoston, Boris G. Wilson, Radhika Mathur, Peter J. Park, Ramesh A. Shivdasani
Publikováno v:
Nature genetics
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in ∼20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b14f501c6258b1feb7016e0edf537ff
https://doi.org/10.1038/ng.3744
https://doi.org/10.1038/ng.3744
Autor:
Craig Mickanin, Linda Bagdasarian, Gregory R. Hoffman, Jeffery A. Porter, Kay Xiang, Huili Zhai, Zainab Jagani, Matthew J. Meyer, Frank Buxton, Vic E. Myer, Nadire Ramadan, Rami Rahal, Elizabeth Frias, Charles W. M. Roberts, Janina Huber, Frank Stegmeier, Kristy Haas, Gregory McAllister, Tanushree Phadke, Mariela Jaskelioff, Rodrigo Romero, Veronica Saenz-Vash, Alicia Lindeman, Dongshu Chen, Boris G. Wilson, Margaret E. McLaughlin, Nicholas Keen
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3128-3133
Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic candidates. We therefore set out to systematically interrogate epigenetic cancer dependenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7b9048773c54b470f77944d734533b
https://doi.org/10.1073/pnas.1316793111
https://doi.org/10.1073/pnas.1316793111
Autor:
Haley E. Manchester, Jeffrey R. Haswell, Youngha Kim, Charles W. M. Roberts, Zainab Jagani, William C. Hahn, Andrew J. Aguirre, Boris G. Wilson, Katherine C. Helming, Mahmoud Ghandi, Zhong Wang, Francisca Vazquez, Gregory V. Kryukov, Levi A. Garraway, Xiaofeng Wang
Publikováno v:
Nature medicine
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-like), is frequently mutated across a variety of human cancers and also has bona fide tumor suppressor properties. Consequently, identification of vulnerabilities c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc490c78ea08f1afbb1bd576c3fc0162
http://europepmc.org/articles/PMC3954704
http://europepmc.org/articles/PMC3954704
Autor:
Burak H. Alver, Charles W. M. Roberts, Erik J. Tillman, Michael Y. Tolstorukov, Boris G. Wilson, Edward C. Koellhoffer, Courtney G. Sansam, Katherine C. Helming, Peter J. Park, Ping Lu, Julia A. Evans
Publikováno v:
Proceedings of the National Academy of Sciences. 110:10165-10170
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established, are dynamically maintained, and subsequently contribute to transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122d08fd28488c76d0e7a67c118c38a4
https://doi.org/10.1073/pnas.1302209110
https://doi.org/10.1073/pnas.1302209110
Autor:
Hye-Jung Kim, Phuong L. Nguyen, Courtney G. Sansam, Boris G. Wilson, Charles W. M. Roberts, Jonathan W. Wischhusen, Xi Wang, Christopher S. Thom, Miriam B. F. Werneck, Michael J. Kluk, Julia A. Evans, Jonathan L. Jesneck, Harvey Cantor
Publikováno v:
Journal of Clinical Investigation. 121:3834-3845
A fundamental goal in cancer research is the identification of the cell types and signaling pathways capable of initiating and sustaining tumor growth, as this has the potential to reveal therapeutic targets. Stem and progenitor cells have been impli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2782f279bfb84b5ffbe896dd51e18a
https://doi.org/10.1172/jci37210
https://doi.org/10.1172/jci37210
Autor:
Charles W. M. Roberts, Boris G. Wilson
Publikováno v:
Nature Reviews Cancer. 11:481-492
SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel nucleosomes and to modulate transcription. Growing evidence indicates that these complexes have a widespread role in tumour suppression, as inactivating mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed474f410d112d044b6e21d23345b7f
https://doi.org/10.1038/nrc3068
https://doi.org/10.1038/nrc3068
Autor:
Charles W. M. Roberts, Scott L. Pomeroy, Yoon Jae Cho, Xiaohua Shen, Madeleine E. Lemieux, Edward C. Koellhoffer, Stuart H. Orkin, Elizabeth S. McKenna, Boris G. Wilson, Xi Wang
Publikováno v:
Cancer Cell. 18(4):316-328
SummaryEpigenetic alterations have been increasingly implicated in oncogenesis. Analysis of Drosophila mutants suggests that Polycomb and SWI/SNF complexes can serve antagonistic developmental roles. However, the relevance of this relationship to hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01f631b0313bbab658d90b80514ad00
Autor:
Charles W. M. Roberts, Agoston T. Agoston, Boris G. Wilson, Burak H. Alver, Adrianna K. San Roman, Radhika Mathur, Xiaofeng Wang, Peter J. Park, Ramesh A. Shivdasani
Publikováno v:
Cancer Research. 77:LB-286
Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are collectively mutated in ~20% of all human cancers, but the mechanism by which these mutations promote tumorigenesis is unclear. In this study, we investigate the tumor suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0b027b04f994fec26c2b27f44f660fb
https://doi.org/10.1158/1538-7445.am2017-lb-286
https://doi.org/10.1158/1538-7445.am2017-lb-286
Autor:
William C. Hahn, Francisca Vazquez, Charles W. M. Roberts, Xiaofeng Wang, Zainab Jagani, Boris G. Wilson, Youngha Kim, Katherine C. Helming
Publikováno v:
Molecular and cellular biology. 34(6)
Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex are mutated in 20% of all human cancers, with the SMARCA4 (BRG1) subunit being one of the most frequently mutated. The SWI/SNF complex modulates chromatin remodel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e792b2ea75f6b12127ce64e34da6ce73
https://pubmed.ncbi.nlm.nih.gov/24421395
https://pubmed.ncbi.nlm.nih.gov/24421395