Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Boris Freydin"'
Publikováno v:
Bioinformatics
Motivation Quantitative immunofluorescence is often used for immunohistochemistry quantification of proteins that serve as cancer biomarkers. Advanced image analysis systems for pathology allow capturing expression levels in each individual cell or s
Autor:
Inna Chervoneva, Hai Hu, Melanie A. Girondo, Amy R. Peck, Chengbao Liu, Albert J. Kovatich, Boris Freydin, Hallgeir Rui, Terry Hyslop, Jeffrey A. Hooke, Edith P. Mitchell, Craig D. Shriver
Publikováno v:
Modern Pathology
Protein marker levels in formalin-fixed, paraffin-embedded tissue sections traditionally have been assayed by chromogenic immunohistochemistry and evaluated visually by pathologists. Pathologist scoring of chromogen staining intensity is subjective a
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) is widely used for molecular diagnostics and evaluating prognosis in cancer. The utility of mRNA expression biomarkers relies heavily on the accuracy and precision of quantificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc6a86caf0467d5b15a7f8a5b6a0a54
https://europepmc.org/articles/PMC5756704/
https://europepmc.org/articles/PMC5756704/
Autor:
Inna Chervoneva, Jeffrey A. Hooke, Amy R. Peck, Edith P. Mitchell, Boris Freydin, Terry Hyslop, Albert J. Kovatich, Hallgeir Rui, Melanie A. Girondo, Craig D. Shriver
Publikováno v:
Cancer Research. 73:P1-08
Previous analyses of three breast cancer cohorts revealed that loss of phospho-Stat5 in breast cancer is associated with significantly elevated risk of hormone therapy failure (1, 2). Nuclear localized tyrosine phosphorylated Stat5 (Nuc-pYStat5) may
Autor:
Jeffrey A. Hooke, Lynn M. Neilson, Thai H. Tran, Inna Chervoneva, Albert J. Kovatich, Hallgeir Rui, Craig D. Shriver, Chengbao Liu, Boris Freydin, Serge Y. Fuchs, Amy R. Peck, Melanie A. Girondo, Takahiro Sato, Terry Hyslop, Chelain R. Goodman
Publikováno v:
Oncogene
Prolactin controls the development and function of milk-producing breast epithelia but also supports growth and differentiation of breast cancer, especially luminal subtypes. A principal signaling mediator of prolactin, Stat5, promotes cellular diffe
Autor:
Alexander C. Klimowicz, Anne L. Rosenberg, Anthony M. Magliocco, Craig D. Shriver, Hallgeir Rui, David L. Rimm, Jeffrey A. Hooke, Ginger A. Stringer, Ning Yang, Terry Hyslop, Boris Freydin, Albert J. Kovatich, Edward Pequignot, Amy R. Peck, Chang Gong Liu, Agnes Witkiewicz, Thai H. Tran
Publikováno v:
Cancer Research. 71:P1-06
Nuclear-localized and tyrosine-phosphorylated Stat5 has been reported as a favorable prognostic marker and predictor of response to antiestrogen therapy in breast cancer. Phospho-Stat5 antibodies do not distinguish between phosphorylated Stat5a and t
Autor:
Matias E. Valsecchi, Boris Freydin, Jonathan R. Brody, Charles J. Yeo, Charalambos C. Solomides, Mph Mary McDonald Md, Stephen C. Peiper, Agnieszka K. Witkiewicz, Terry Hyslop
Publikováno v:
Cancer. 118:3484-3493
BACKGROUND: The aim of this study was to evaluate the expression of epidermal growth factor receptor (EGFR) and insulinlike growth factor 1 receptor (IGF-1R) proteins and IGF-1R gene copy numbers in pancreatic ductal adenocarcinoma in relation to pat
Autor:
Tatiyana V. Apanasovich, Boris Freydin, Erik S. Knudsen, Jessica Kline, Gordon F. Schwartz, Agnes Witkiewicz
Publikováno v:
Cancer Research. 70:P1-15
The retinoblastoma (RB) tumor suppressor is functionally inactivated at high frequency in human malignancies including breast cancer. By immunohistochemistry loss of RB function is associated with p16ink4a overexpression and high Ki67 proliferation i
Autor:
David W. Rittenhouse, Eugene P. Kennedy, Jonathan R. Brody, Nathan G. Richards, Joseph A. Cozzitorto, Charles J. Yeo, Hallgeir Rui, Agnieszka K. Witkiewicz, Greg Gonye, Dane R. Grenda, Boris Freydin
Publikováno v:
Annals of Surgery. 252:499-506
Background: Pancreatic ductal adenocarcinoma (PDA) is a devastating disease that killed nearly 38,000 people in the United States this past year. Objective: Treatment of PDA typically includes surgery and/or chemotherapy with gemcitabine. No reliable
Autor:
Hallgeir Rui, Boris Freydin, Agnieszka K. Witkiewicz, Gordon F. Schwartz, Wendy Rizzo, Jonathan R. Brody, Inna Chervoneva, Magdalena Potoczek, Michael P. Lisanti
Publikováno v:
Cancer Biology & Therapy. 10:391-396
The current classification of ductal carcinoma in situ (DCIS) is based on nuclear grade, architectural differentiation and the presence of necrosis that does not adequately predict the likelihood of recurrence after breast conserving therapy; therefo