Discovery of Novel Small-Molecule Compounds with Selective Cytotoxicity for Burkitt’s Lymphoma Cells Using 3D Ligand-Based Virtual Screening

Autor: Martina Gobec, Izidor Sosič, Boris Brus, Aleš Obreza, Stanislav Gobec, Irena Mlinarič-Raščan

Publikováno v: Molecules, Vol 19, Iss 11, Pp 19209-19219 (2014)

We describe a ligand-based approach towards compounds with more specific targeting for Burkitt’s lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are c

Externí odkaz: https://doaj.org/article/9f1e9e27e86545b3af0a0b1fffba65d7

Aggressive conditions during primary drying as a contemporary approach to optimise freeze-drying cycles of biopharmaceuticals

Autor: Pegi Ahlin Grabnar, Manca Logar, Katarina Bolko Seljak, Uroš Trstenjak, Boris Brus, Maja Bjelošević

Publikováno v: European Journal of Pharmaceutical Sciences. 122:292-302

Freeze-drying is the method of choice to dry formulations with biopharmaceutical drugs, to enhance protein stability. This is usually done below the glass transition temperature of maximally freeze-concentrated solutions (T g ′), to avoid protein a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a9b81bec57d361e7128a75c865de98
https://doi.org/10.1016/j.ejps.2018.07.016

Nep1-like proteins as a target for plant pathogen control

Autor: Anita Kotar, Izidor Sosič, Thorsten Nürnberger, Gregor Anderluh, Janez Plavec, Katja Pirc, Jure Borišek, Stanislav Gobec, Marjetka Podobnik, Simon Caserman, Martina Damuzzo, Tea Lenarčič, Vesna Hodnik, Isabell Albert, Hannah Böhm, Tina Snoj, Boris Brus, Alessandra Magistrato

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 4, p e1009477 (2021)

The lack of efficient methods to control the major diseases of crops most important to agriculture leads to huge economic losses and seriously threatens global food security. Many of the most important microbial plant pathogens, including bacteria, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b6df3ead0543b41cadc2dc40368e4c
https://doi.org/10.1371/journal.ppat.1009477

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Autor: Adrian Podkowa, Anja Pišlar, Florian Nachon, Urban Košak, Kinga Sałat, Jure Stojan, Boris Brus, Jurij Trontelj, Nicolas Coquelle, Jacques-Philippe Colletier, Simon Žakelj, Damijan Knez, Xavier Brazzolotto, Roman Šink, Marko Jukič, Stanislav Gobec, Marko Živin, Janko Kos

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (1), pp.119-139. ⟨10.1021/acs.jmedchem.7b01086⟩
Journal of Medicinal Chemistry, 2018, 61 (1), pp.119-139. ⟨10.1021/acs.jmedchem.7b01086⟩

International audience; The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the progression of Alzheimer's disease, thus classifying BChE as a promising drug target in advanced Alzheimer's disease. We used structure-bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb24ec04f8a5814caef80c8bf2a5f252
https://hal.archives-ouvertes.fr/hal-01991973

Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

Autor: Katarzyna Dudek, Marek Bajda, Natalia Szałaj, Stanislav Gobec, Barbara Malawska, Boris Brus

Publikováno v: Archiv der Pharmazie. 348:556-563

Alzheimer's disease (AD) is a fatal and complex neurodegenerative disorder for which effective treatment remains the unmet challenge. Using donepezil as a starting point, we aimed to develop novel potential anti-AD agents with a multidirectional biol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0883e2b6b5079fd28f7e7c83eac00cf
https://doi.org/10.1002/ardp.201500117