Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Boris Aguilar"'
Autor:
Yue Zhang, Guangrong Qin, Boris Aguilar, Noa Rappaport, James T. Yurkovich, Lance Pflieger, Sui Huang, Leroy Hood, Ilya Shmulevich
Publikováno v:
Frontiers in Digital Health, Vol 6 (2024)
IntroductionA digital twin is a virtual representation of a patient's disease, facilitating real-time monitoring, analysis, and simulation. This enables the prediction of disease progression, optimization of care delivery, and improvement of outcomes
Externí odkaz:
https://doaj.org/article/42febbed3fe641b9be4078e0077dd232
Autor:
Fernando Cantarero-Rivera, Jaro Camphuijsen, Greg Potter, Chris Clark, Jiajia Chen, Simon Kahan, Boris Aguilar
Publikováno v:
Frontiers in Food Science and Technology, Vol 3 (2024)
Highly productive and efficient biomass growth in bioreactors is an essential bioprocess outcome in many industrial applications. Large-scale biomass creation in the cultivated meat industry will be critical given the demand size in the conventional
Externí odkaz:
https://doaj.org/article/5fe0757681cd4ed7b654e4343862c129
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0282122 (2023)
The capacity of cells to process information is currently used to design cell-based tools for ecological, industrial, and biomedical applications such as detecting dangerous chemicals or for bioremediation. In most applications, individual cells are
Externí odkaz:
https://doaj.org/article/5b9c6966ed1740d0a8c1d02f46a20cc9
Autor:
William Longabaugh, John Phan, Christopher J. Kemp, David Pot, Guangrong Qin, Bahar Tercan, Boris Aguilar, Taek-Kyun Kim, Ilya Shmulevich, Nyasha Chambwe
Publikováno v:
F1000Research, Vol 11 (2022)
Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in cancer, as exemplified by the recent success of PARP inh
Externí odkaz:
https://doaj.org/article/7c4bbf65475849088bbbbf90b4c43749
Autor:
Eric A. Stahlberg, Mohamed Abdel-Rahman, Boris Aguilar, Alireza Asadpoure, Robert A. Beckman, Lynn L. Borkon, Jeffrey N. Bryan, Colleen M. Cebulla, Young Hwan Chang, Ansu Chatterjee, Jun Deng, Sepideh Dolatshahi, Olivier Gevaert, Emily J. Greenspan, Wenrui Hao, Tina Hernandez-Boussard, Pamela R. Jackson, Marieke Kuijjer, Adrian Lee, Paul Macklin, Subha Madhavan, Matthew D. McCoy, Navid Mohammad Mirzaei, Talayeh Razzaghi, Heber L. Rocha, Leili Shahriyari, Ilya Shmulevich, Daniel G. Stover, Yi Sun, Tanveer Syeda-Mahmood, Jinhua Wang, Qi Wang, Ioannis Zervantonakis
Publikováno v:
Frontiers in Digital Health, Vol 4 (2022)
We are rapidly approaching a future in which cancer patient digital twins will reach their potential to predict cancer prevention, diagnosis, and treatment in individual patients. This will be realized based on advances in high performance computing,
Externí odkaz:
https://doaj.org/article/46e800c638964bf3bdfa34d7236e108c
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104951- (2022)
Summary: We developed a computational approach to find the best intervention to achieve transcription factor (TF) mediated transdifferentiation. We construct probabilistic Boolean networks (PBNs) from single-cell RNA sequencing data of two different
Externí odkaz:
https://doaj.org/article/b856b7ecc15d4d0583d23fc89a21619d
Publikováno v:
Entropy, Vol 25, Iss 2, p 319 (2023)
Communication between cells enables the coordination that drives structural and functional complexity in biological systems. Both single and multicellular organisms have evolved diverse communication systems for a range of purposes, including synchro
Externí odkaz:
https://doaj.org/article/e1e93d091c644d5798059f2025e5dfd9
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The maintenance and function of tissues in health and disease depends on cell–cell communication. This work shows how high-level features, representing cell–cell communication, can be defined and used to associate certain signaling “axes” wit
Externí odkaz:
https://doaj.org/article/bccdebd8be4742e3a54c33ce7983d479
Autor:
Eliza J.R. Peterson, Abrar A. Abidi, Mario L. Arrieta-Ortiz, Boris Aguilar, James T. Yurkovich, Amardeep Kaur, Min Pan, Vivek Srinivas, Ilya Shmulevich, Nitin S. Baliga
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109287- (2021)
Externí odkaz:
https://doaj.org/article/1abf755d817443709719f3666ca00913
Autor:
Eliza J.R. Peterson, Abrar A. Abidi, Mario L. Arrieta-Ortiz, Boris Aguilar, James T. Yurkovich, Amardeep Kaur, Min Pan, Vivek Srinivas, Ilya Shmulevich, Nitin S. Baliga
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Mycobacterium tuberculosis (MTB) displays the remarkable ability to transition in and out of dormancy, a hallmark of the pathogen’s capacity to evade the immune system and exploit susceptible individuals. Uncovering the gene regulatory pro
Externí odkaz:
https://doaj.org/article/c019f6341eab44dc908e3aa1afddd802