Výsledky vyhledávání - "Boris A. Leibovitch"

Akademický článek

The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells

Autor: Nisha Rani Dahiya, Boris A. Leibovitch, Rama Kadamb, Nidhi Bansal, Samuel Waxman

Publikováno v: Cells, Vol 11, Iss 7, p 1179 (2022)

Retinoids are essential in balancing proliferation, differentiation and apoptosis, and they exert their effects through retinoic acid receptors (RARs) and retinoid X receptors (RXRs). RARβ is a tumor-suppressor gene silenced by epigenetic mechanisms

Externí odkaz: https://doaj.org/article/8a0d23dd00bc4165aa2de2446ac8b453

Zobrazit plný text záznamu

Akademický článek

Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

Autor: Rama Kadamb, Boris A Leibovitch, Eduardo F Farias, Nisha Dahiya, Hemant Suryawanshi, Nidhi Bansal, Samuel Waxman

Publikováno v: Translational Oncology, Vol 16, Iss , Pp 101320- (2022)

SIN3A, a scaffold protein has regulatory functions in tumor biology. Through its Paired amphipathic helix (PAH2) domain, SIN3A interacts with PHF12 (PF1), a protein with SIN3 interaction domain (SID) that forms a complex with MRG15 and KDM5A/B. These

Externí odkaz: https://doaj.org/article/c27e9a15035544499057071060a93669

Zobrazit plný text záznamu

Supplementary Table S1 and Fig S1 and S2 from Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

Supplementary Table S1 and Fig S1 and S2. Supplementary Table 1: qPCR primers used in this study; Supplementary Figure S1: Structures of compounds screened in Figure 1A and 1B; Supplementary Figure S2: Proximity ligation assay (PLA) analyzing SIN3A-M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2661226bcf1adfebdb4ad0b4e75309
https://doi.org/10.1158/1535-7163.22501737.v1

Zobrazit plný text záznamu

Supplementary Table S2 from Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

Supplementary Table S2. List of genes with expression regulated by selamectin treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359c53a496fbbd8957c2887bf8f293a8
https://doi.org/10.1158/1535-7163.22501731.v1

Zobrazit plný text záznamu

Data from Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

Triple-negative breast cancers (TNBC) lacking estrogen, progesterone, and HER2 receptors account for 10% to 20% of breast cancer and are indicative of poor prognosis. The development of effective treatment strategies therefore represents a pressing u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56370da14bb776869d71153456a22616
https://doi.org/10.1158/1535-7163.c.6536886.v1

Zobrazit plný text záznamu

Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells

Autor: Boris A. Leibovitch, Arthur Zelent, Eduardo F. Farias, Yeon-Jin Kwon, Samuel Waxman, Nidhi Bansal, Lutecia Pereira, Edgardo V. Ariztia, Chi-Yeh Chung

Publikováno v: Oncotarget

// Yeon-Jin Kwon 1 , Boris A. Leibovitch 1 , Nidhi Bansal 1 , Lutecia Pereira 2 , Chi-Yeh Chung 1 , Edgardo V. Ariztia 1 , Arthur Zelent 2 , Eduardo F. Farias 1 and Samuel Waxman 1 1 Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3d348467d5031a83c97508d72420a6
http://europepmc.org/articles/PMC5687616

Zobrazit plný text záznamu

Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer

Autor: Jianshi Yu, Jace W. Jones, Lutecia Pereira, Maureen A. Kane, Melissa Fishel, Arthur Zelent, Elena Cubedo, Boris A. Leibovitch, Keely Pierzchalski, Eduardo F. Farias, Almudena Bosch, Samuel Waxman, Nidhi Bansal

Publikováno v: Oncotarget

// Nidhi Bansal 1 , Almudena Bosch 1, * , Boris Leibovitch 1, * , Lutecia Pereira 2 , Elena Cubedo 2 , Jianshi Yu 3 , Keely Pierzchalski 3 , Jace W. Jones 3 , Melissa Fishel 1 , Maureen Kane 3 , Arthur Zelent 2 , Samuel Waxman 1 , Eduardo Farias 1 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99ff7e886132ac7856d52eb06a74baa
https://doi.org/10.18632/oncotarget.9905

Zobrazit plný text záznamu

Abstract 31: Targeted dissociation of PF1 from SIN3A chromatin regulator complex inhibits tumor growth and metastasis in triple-negative breast cancer

Autor: Boris A. Leibovitch, Nidhi Bansal, Rama Kadamb, Samuel Waxman, Eduardo F. Farias, Yeon-Jin Kwon, Ming-Ming Zhou

Publikováno v: Cancer Research. 78:31-31

Triple negative breast cancer (TNBC) is characterized by an aggressive, poorly differentiated phenotype associated with early recurrence. Chemotherapy is the only treatment option due to the lack of an effective molecular target. Targeting reversible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0b8d9200c8f0184d066226eab3b9001
https://doi.org/10.1158/1538-7445.am2018-31

Zobrazit plný text záznamu

Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells

Autor: Boris A. Leibovitch, Janice Murtagh, Kevin Petrie, Eduardo F. Farias, Tino Schenk, Manuel Boix Chornet, Arthur Zelent, Samuel Waxman

Publikováno v: Proceedings of the National Academy of Sciences. 107:11811-11816

Sin3A/B is a master transcriptional scaffold and corepressor that plays an essential role in the regulation of gene transcription and maintenance of chromatin structure, and its inappropriate recruitment has been associated with aberrant gene silenci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b772a18b9ac07c553f1de590702a59ab
https://doi.org/10.1073/pnas.1006737107

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání