Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Boris Yagen"'
Autor:
Pishan Chang, Benoit Orabi, Rania M. Deranieh, Manik Dham, Oliver Hoeller, Jakob A. Shimshoni, Boris Yagen, Meir Bialer, Miriam L. Greenberg, Matthew C. Walker, Robin S. B. Williams
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 1, Pp 115-124 (2012)
SUMMARY Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. Our previous work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple
Externí odkaz:
https://doaj.org/article/d203726140b3427493440a80b9c53ea0
Publikováno v:
Journal of food protection. 52(8)
A promising method for the destruction of aflatoxin B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ba3aa257421d9d17befaa7f091186d6
https://pubmed.ncbi.nlm.nih.gov/31003328
https://pubmed.ncbi.nlm.nih.gov/31003328
Publikováno v:
Epilepsy & Behavior. 49:298-302
sec-Butylpropylacetamide (SPD) is a one-carbon homologue of valnoctamide (VCD), a chiral constitutional isomer of valproic acid's (VPA) corresponding amide--valpromide. Racemic-SPD and racemic-VCD possess a unique and broad-spectrum antiseizure profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3b6e07d06554ca0cfd2a21db11f3a3
https://doi.org/10.1016/j.yebeh.2015.04.012
https://doi.org/10.1016/j.yebeh.2015.04.012
Publikováno v:
Clinical Biochemistry. 46:1532-1537
Purpose To determine the cytotoxicity of valproic acid (VPA) and its derivatives in human hepatoblastoma (HepG2) cells, and to study the possible toxicity of these compounds in human lymphocytes from patients with known hypersensitivity syndrome reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4318ff9b94b20251b42436f56c0d6c
https://doi.org/10.1016/j.clinbiochem.2013.07.003
https://doi.org/10.1016/j.clinbiochem.2013.07.003
Publikováno v:
Epilepsia. 54:99-102
Summary sec-Butyl-propylacetamide (SPD) is a one-carbon homolog of valnoctamide (VCD), a chiral constitutional isomer of valproic acid's (VPA) corresponding amide valpromide. VCD has potential as a therapy in epilepsy including status epilepticus (SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634b643eaf1a5629015f0e7fd4f7331a
https://doi.org/10.1111/epi.12290
https://doi.org/10.1111/epi.12290
Autor:
Meir Bialer, Wendy A. Pouliot, K. Ricks, C. Nelson, Tawfeeq Shekh-Ahmad, F.E. Dudek, Naama Hen, Boris Yagen, Bonnie Roach, Dan Kaufmann
Publikováno v:
Neuroscience. 231:145-156
Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies. The effect of sec-butyl-propylacetamide (SPD), an amide derivative of valproic acid (VPA), on electrographic statu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d9fd81652e547d13ab0753b9743747
https://doi.org/10.1016/j.neuroscience.2012.11.005
https://doi.org/10.1016/j.neuroscience.2012.11.005
Autor:
H. Steve White, Misty D. Smith, Kevin C. Brennan, Marshall Devor, Meir Bialer, Dan Kaufmann, Boris Yagen, Peter J. West
Publikováno v:
Pharmacological research. 117
Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population. sec-Butylpropylacetamide (SPD) is a novel amide analogue of valproic acid (VPA) previously shown to posse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6996d6a2c35e12ac85c7d4fc47f85a5e
https://pubmed.ncbi.nlm.nih.gov/27890817
https://pubmed.ncbi.nlm.nih.gov/27890817
Publikováno v:
Journal of Medicinal Chemistry. 55:2835-2845
A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5bb706c48671f9f821b5cfa8076672
https://doi.org/10.1021/jm201751x
https://doi.org/10.1021/jm201751x
Autor:
James P. Stables, Naama Hen, John H. McDonough, Amanda L. Pollock, H. Steve White, Dan Kaufmann, Anitha Alex, Karen S. Wilcox, Meir Bialer, Boris Yagen, Tawfeeq Shekh-Ahmad
Publikováno v:
Epilepsia. 53:134-146
Purpose sec-Butyl-propylacetamide (SPD) is a one-carbon homologue of valnoctamide (VCD), a CNS-active amide derivative of valproic acid (VPA) currently in phase II clinical trials. The current study evaluated the anticonvulsant activity of SPD in a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c70ce7ef477c3aaa5c4aac22b1989c4
https://doi.org/10.1111/j.1528-1167.2011.03338.x
https://doi.org/10.1111/j.1528-1167.2011.03338.x
Autor:
Andrea Scozzafava, Boris Yagen, Robert McKenna, Claudiu T. Supuran, Naama Hen, Alfonso Maresca, Mayank Aggarwal, Arthur H. Robbins, Meir Bialer
Publikováno v:
Journal of Medicinal Chemistry; Vol 54
Aromatic amides comprising branched aliphatic carboxylic acids and 4-aminobenzenesulfonamide were evaluated for their inhibition of carbonic anhydrase (CA) isoforms. Of the most anticonvulsant-active compounds (2, 4, 13, 16, and 17), only 13, 16, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baab1f9ebd4230dc4ee3cf51b131671