Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Boriana Popkirova"'
1
Mapping the isoprenoid binding pocket of PDEδ by a semisynthetic, photoactivatable N-ras lipoprotein
Autor: Radovan Dvorsky, Herbert Waldmann, Markos Pechlivanis, Boriana Popkirova, Jürgen Kuhlmann, Luc Brunsveld, Michael Alexander, Marc Gerauer
Publikováno v: ChemBioChem, 10(1), 98-108. Wiley-VCH Verlag
Biologically functional Ras isoforms undergo post-translational modifications starting with farnesylation of the most C-terminal cysteine. Combined with further processing steps, this isoprenylation allows for the anchoring of these proteins in endom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4195c0d72e4c744891e76829b8115a5b
https://doi.org/10.1002/cbic.200800275
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2
Prenylation of Ras Facilitates hSOS1-Promoted Nucleotide Exchange, upon Ras Binding to the Regulatory Site
Autor: J. Kuhlmann, Rieke Ringel, Boriana Popkirova, Markos Pechlivanis
Publikováno v: Biochemistry. 46:5341-5348
The oncoprotein Ras is anchored in lipid membranes due to its C-terminal lipid modification. The ubiquitously expressed Ras nucleotide exchange-factor hSOSI promotes nucleotide exchange and thus Ras activation. This reaction is enhanced by a positive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c95548077f248531eecbced6c4a832
https://doi.org/10.1021/bi602353k
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4
Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library
Autor: Jürgen Kuhlmann, Michael Thutewohl, Thorsten Nowak, Michael Bate, Ionna-Maria Karaguni, Lars Kissau, Oliver Müller, Boriana Popkirova, Herbert Waldmann
Publikováno v: Bioorganic & Medicinal Chemistry. 11:2617-2626
A library of 51 analogues of the naturally occurring protein farnesyltransferase inhibitor pepticinnamin E was investigated biologically. Several compounds with pronounced inhibitory activity were discovered with the lowest IC 50 value reaching 1 μM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b569638b1e14e7578c563c870a387893
https://doi.org/10.1016/s0968-0896(03)00160-3
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8
Synthesis and biological activity of photoactivatable N-ras peptides and proteins
Autor: Koji Uwai, Jürgen Kuhlmann, Melanie Wagner, Herbert Waldmann, Andreas Tebbe, Martin Völkert, Boriana Popkirova
Publikováno v: Journal of the American Chemical Society. 125(42)
A modular strategy for the assembly of farnesylated N-Ras heptapeptides carrying a photoactivatable benzophenone (BP) group within the lipid residue is described. This strategy is based on the fragment condensation of a N-terminal hexapeptide synthes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0938ca3704cda1c546e3107e454b4e00
https://pubmed.ncbi.nlm.nih.gov/14558822
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