Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Bori Shushan"'
Autor:
Bori Shushan
Publikováno v:
Mass Spectrometry Reviews. 29:930-944
Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) technology is emerging as a complementary method to traditional methodology used for clinical applications. Enhanced specificity and high-throughput capabilities are providing sig
Autor:
Víctor R. De Jesús, David C. Kasper, Bori Shushan, Thomas F. Metz, Thomas P. Mechtler, Joseph L. Herman
Publikováno v:
Rapid Communications in Mass Spectrometry. 24:986-994
Lysozomal storage disorders are just beginning to be routinely screened using enzyme activity assays involving dried blood spots and tandem mass spectrometry (MS/MS). This paper discusses some of the analytical challenges associated with published as
Publikováno v:
Clinical Chemistry. 48:323-331
Background: Determination of urinary catecholamines (CATs) is considered important for clinical diagnosis of pheochromocytoma, paraganglioma, and neuroblastoma. The major disadvantages of existing tests include relatively long instrumental analysis t
Publikováno v:
Clinical Chemistry. 47:1993-2002
Background: Methylmalonic acid (MMA) is a dicarboxylic acid whose concentration can be increased in blood and urine in patients with an inborn error of metabolism or vitamin B12 deficiency. We developed a method for the selective analysis of dicarbox
Publikováno v:
Rapid Communications in Mass Spectrometry. 11:325-329
Three cases of protein characterization are presented where mixed-mode scanning sequences are executed. The processes involve identification of sites of glycosylation in fetuin, and phosphorylation in β-casein (based on work by Carr et al) and deter
Autor:
Ron Bonner, Bori Shushan
Publikováno v:
Rapid Communications in Mass Spectrometry. 9:1077-1080
A method for matching proteins in databases with unknown samples using data derived from peptide product ion masses is described. The power of the method is due to the speed of analysis and to the ability to locate proteins in a database even when th
Autor:
Katharina M. Ostermann, Hannes G. Müller, Thomas P. Mechtler, Kurt R. Herkner, Joseph M. Di Bussolo, Bori Shushan, Víctor R. De Jesús, Rene Ratschmann, Thomas F. Metz, Joseph L. Herman, David C. Kasper
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 908
The interest in screening lysosomal storage disorders (LSDs) in newborns and high-risk population has increased in the last years due to the availability of novel treatment strategies coupled with the development of diagnostic techniques. We report t
Publikováno v:
Analytical Chemistry. 66:236-243
Packed capillary perfusion columns were evaluated for their ability to rapidly separate and sequence enzyme digest by HPLC/MS/MS using electrospray ionization (ESI) and were compared directly against packed capillary (180-μm and 320-μm i.d.) and mi
Publikováno v:
Clinical Chemistry. 48:1126-1128
Measurements of acylcarnitines in plasma have several diagnostic applications, and various tandem mass spectrometry methods are more specific and accurate than earlier methods (1)(2)(3)(4). Libert et al. (5) reported that propionylcarnitine (PrCRN) a
Autor:
Bori Shushan, Thomas P. Mechtler, David C. Kasper, Chike B. Item, Monica Martin, Joseph J. Orsini, Kurt R. Herkner, Berthold Streubel, Joseph L. Herman, Thomas F. Metz, Rene Ratschmann
Publikováno v:
Clinical chemistry. 57(9)
BACKGROUND Interest in lysosomal storage disorders, a collection of more than 40 inherited metabolic disorders, has increased because of new therapy options such as enzyme replacement, stem cell transplantation, and substrate reduction therapy. We de