Late eating is associated with poor glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 diabetes.

Autor: Díaz-Rizzolo DA; Division of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA.; Health Science Faculty, Universitat Oberta de Catalunya, Barcelona, Spain., Santos Baez LS; Division of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA., Popp CJ; Department of Population Health, New York Langone Health Grossman School of Medicine, New York, NY, USA., Borhan R; Division of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA., Sordi-Guth A; Division of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA., Manoogian ENC; Salk Institute for Biological Studies, Regulatory Biology Laboratory, La Jolla, CA, USA., Panda S; Salk Institute for Biological Studies, Regulatory Biology Laboratory, La Jolla, CA, USA., Cheng B; Department of Biostatistics, Columbia University Irving Medical Center, New York, NY, USA., Laferrère B; Division of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA. bbl14@columbia.edu.

Publikováno v: Nutrition & diabetes [Nutr Diabetes] 2024 Oct 25; Vol. 14 (1), pp. 90. Date of Electronic Publication: 2024 Oct 25.

Analysis of nonleukemic cellular subcompartments reconstructs clonal evolution of acute myeloid leukemia and identifies therapy‐resistant preleukemic clones

Autor: Anthony D. Ho, Wolfgang Huber, Anna Jauch, Volker Eckstein, Andreas Trumpp, Linda Manta, Borhan R. Saeed, Wenwen Wang, Paul Theodor Pyl, Simon Raffel, Christoph Lutz, Eike C. Buss

Publikováno v: International Journal of Cancer. 148:2825-2838

To acquire a better understanding of clonal evolution of acute myeloid leukemia (AML) and to identify the clone(s) responsible for disease recurrence, we have comparatively studied leukemia-specific mutations by whole-exome-sequencing (WES) of both t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58062e2ded4d5ab76d74443e56b5dff
https://doi.org/10.1002/ijc.33461

N,N‑diethylaminobenzaldehyde targets aldehyde dehydrogenase to eradicate human pancreatic cancer cells

Autor: Hao Ge, Wenwen Wang, Shiya Zheng, Borhan R. Saeed, Haiju He

Publikováno v: Exp Ther Med

Pancreatic cancer is a common cause of worldwide cancer-related mortality with a poor 5-year survival rate. Aldehyde dehydrogenase (ALDH) activity is a possible marker for malignant stem cells in solid organ systems, including the pancreas, and N,N-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d035744ace77127323c43b7d7190223
https://doi.org/10.3892/etm.2020.8691

The molecular signature of AML with increased ALDH activity suggests a stem cell origin

Autor: Olga Ermakova, Christoph Lutz, Andreas Trumpp, Vladimir Benes, Simon Raffel, Borhan R. Saeed, Volker Eckstein, Anthony D. Ho, Eugen Rempel, Wenwen Wang, Rachel Blume, Linda Manta

Publikováno v: Leukemia & Lymphoma. 59:2201-2210

Enrichment of leukemic blasts with a stem cell phenotype correlates with poor survival in acute myeloid leukemia (AML). In this context, measurement of the stem cell marker aldehyde-dehydrogenase (ALDH) activity can distinguish poor prognosis cases w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1be35eb5e250bd5355836754315718
https://doi.org/10.1080/10428194.2017.1422862

N,N-diethylaminobenzaldehyde targets aldehyde dehydrogenase to eradicate human pancreatic cancer cells.

Autor: Wang, Wenwen, Zheng, Shiya, He, Haiju, Ge, Hao, Saeed, Borhan R.

Publikováno v: Experimental & Therapeutic Medicine; Jul2020, Vol. 20 Issue 1, p662-670, 9p