NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.

Autor: Zhang SM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden., Rehling D; Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden., Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden., Throup A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; Sygnature Discovery Limited, BioCity, Pennyfoot Street, Nottingham NG1 1GR, UK., Landázuri N; Microbial Pathogenesis Unit, Department of Medicine, Karolinska Institutet, 17164 Stockholm, Sweden; DIS Stockholm, Melodislingan 21, 11551 Stockholm, Sweden., Almlöf I; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden., Göttmann M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; German Cancer Research Center (DKFZ), Division of Brain Tumor Translational Targets, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany., Valerie NCK; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, 14152 Huddinge, Sweden., Borhade SR; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; Red Glead Discovery AB, Scheelevägen 2, 22363 Lund, Sweden., Wakchaure P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; Recipharm OT Chemistry AB, Virdings Alle 16, 75450 Uppsala, Sweden., Page BDG; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Desroses M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; Sprint Bioscience AB, Hälsovägen 7, 14157 Huddinge, Sweden., Homan EJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden., Scobie M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden., Rudd SG; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden., Berglund UW; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden., Söderberg-Nauclér C; Microbial Pathogenesis Unit, Department of Medicine, Karolinska Institutet, 17164 Stockholm, Sweden; Division of Neurology, Karolinska University Hospital, 17177 Stockholm, Sweden., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden; Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden. Electronic address: stenmark@dbb.su.se., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Box 1031, 17165 Stockholm, Sweden; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK. Electronic address: thomas.helleday@scilifelab.se.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2021 Dec 16; Vol. 28 (12), pp. 1693-1702.e6. Date of Electronic Publication: 2021 Jun 29.

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides.

Autor: Borhade SR; Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden)., Rosenström U; Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden)., Sävmarker J; Beijer Laboratory, Department of Medicinal Chemistry, BMC, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden)., Lundbäck T; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet Stockholm 171 77 (Sweden)., Jenmalm-Jensen A; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet Stockholm 171 77 (Sweden)., Sigmundsson K; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet Stockholm 171 77 (Sweden)., Axelsson H; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet Stockholm 171 77 (Sweden)., Svensson F; Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden)., Konda V; Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden)., Sköld C; Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden)., Larhed M; Department of Medicinal Chemistry, Science for Life Laboratory, BMC, Uppsala University P.O. Box 574, 751 23 Uppsala (Sweden)., Hallberg M; Beijer Laboratory, Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, BMC, Uppsala University P.O. Box 591, 751 24 Uppsala (Sweden) E-mail: mathias.hallberg@farmbio.uu.se.

Publikováno v: ChemistryOpen [ChemistryOpen] 2014 Dec; Vol. 3 (6), pp. 256-63. Date of Electronic Publication: 2014 Nov 21.

Studies on Pd/NiFe(2)O(4) catalyzed ligand-free Suzuki reaction in aqueous phase: synthesis of biaryls, terphenyls and polyaryls.

Autor: Borhade SR; Department of Chemistry, University of Pune, Ganeshkhind, Pune-411007, India., Waghmode SB

Publikováno v: Beilstein journal of organic chemistry [Beilstein J Org Chem] 2011 Mar 15; Vol. 7, pp. 310-9. Date of Electronic Publication: 2011 Mar 15.