Exploring immune response toward transplanted human kidney tissues assembled from organoid building blocks.

Autor: Borges TJ; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Ganchiku Y; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Aceves JO; Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United states., van Gaal R; Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United states., Uzel SGM; Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United states.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United states., Rosales IA; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United states., Rubins JE; Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United states., Kobayashi K; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United states.; Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Hiratsuka K; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United states.; Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Tekguc M; Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states.; Harvard Stem Cell Institute (HSCI), Cambridge, MA, United states., Ribas GT; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Lima K; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Gassen RB; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Morizane R; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United states.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United states.; Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states., Lewis JA; Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United states.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United states.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United states., Riella LV; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United states.

Publikováno v: IScience [iScience] 2024 Sep 13; Vol. 27 (10), pp. 110957. Date of Electronic Publication: 2024 Sep 13 (Print Publication: 2024).

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models.

Autor: Efe O; Center for Transplantation Sciences, Department of Surgery.; Division of Nephrology, Department of Medicine, and., Gassen RB; Center for Transplantation Sciences, Department of Surgery., Morena L; Center for Transplantation Sciences, Department of Surgery., Ganchiku Y; Center for Transplantation Sciences, Department of Surgery., Al Jurdi A; Center for Transplantation Sciences, Department of Surgery.; Division of Nephrology, Department of Medicine, and., Lape IT; Center for Transplantation Sciences, Department of Surgery., Ventura-Aguiar P; Center for Transplantation Sciences, Department of Surgery., LeGuern C; Center for Transplantation Sciences, Department of Surgery., Madsen JC; Center for Transplantation Sciences, Department of Surgery.; Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Shriver Z; Visterra Inc., Waltham, Massachusetts, USA., Babcock GJ; Visterra Inc., Waltham, Massachusetts, USA., Borges TJ; Center for Transplantation Sciences, Department of Surgery., Riella LV; Center for Transplantation Sciences, Department of Surgery.; Division of Nephrology, Department of Medicine, and.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Mar 01; Vol. 134 (5). Date of Electronic Publication: 2024 Mar 01.

Stress biology: Complexity and multifariousness in health and disease.

Autor: Mayer MP; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany. Electronic address: m.mayer@zmbh.uni-heidelberg.de., Blair L; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA., Blatch GL; Biomedical Research and Drug Discovery Research Group, Faculty of Health Sciences, Higher Colleges of Technology, Sharjah, United Arab Emirates; Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa., Borges TJ; Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Chadli A; Georgia Cancer Center, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA., Chiosis G; Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., de Thonel A; CNRS, UMR 7216, 75250 Paris Cedex 13, Paris, France; Univeristy of Paris Diderot, Sorbonne Paris Cité, Paris, France; Département Hospitalo-Universitaire DHU PROTECT, Paris, France., Dinkova-Kostova A; Division of Cellular and Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, UK., Ecroyd H; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales 2522, Australia., Edkins AL; Biomedical Biotechnology Research Unit (BioBRU), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa., Eguchi T; Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan., Fleshner M; Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA., Foley KP; Ranok Therapeutics, Waltham, MA 02451, USA., Fragkostefanakis S; Department of Biosciences, Molecular Cell Biology of Plants, Goethe University Frankfurt am Main, Frankfurt am Main 60438, Germany., Gestwicki J; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94158, USA., Goloubinoff P; Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Heritz JA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Heske CM; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Hibshman JD; Biology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Joutsen J; Department of Pathology, Lapland Central Hospital, Lapland Wellbeing Services County, Rovaniemi, Finland., Li W; Department of Dermatology and the Norris Comprehensive Cancer Center, University of Southern California Keck Medical Center, Los Angeles, CA 90033, USA., Lynes M; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA., Mendillo ML; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Mivechi N; Molecular Chaperone Biology, Medical College of Georgia, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA., Mokoena F; Department of Biochemistry, North-West University, Mmabatho 2735, South Africa., Okusha Y; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Prahlad V; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA., Repasky E; Department of Hematology and Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Sannino S; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Scalia F; Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy., Shalgi R; Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel., Sistonen L; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Sontag E; Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA., van Oosten-Hawle P; Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA., Vihervaara A; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden., Wickramaratne A; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Wang SXY; Developmental Therapeutics Program, VCU Comprehensive Massey Cancer Center, VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA., Zininga T; Department of Biochemistry, Stellenbosch University, Stellenbosch 7602, South Africa.

Publikováno v: Cell stress & chaperones [Cell Stress Chaperones] 2024 Feb; Vol. 29 (1), pp. 143-157. Date of Electronic Publication: 2024 Feb 03.

Inhibitory innate receptors and their potential role in transplantation.

Autor: Lima K; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil., Ribas GT; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Professional and Technological Education Sector, Federal University of Paraná, Curitiba, Paraná, Brazil., Riella LV; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Borges TJ; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: tdejesusborges@mgh.harvard.edu.

Publikováno v: Transplantation reviews (Orlando, Fla.) [Transplant Rev (Orlando)] 2023 Jul; Vol. 37 (3), pp. 100776. Date of Electronic Publication: 2023 Jul 07.

SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies.

Autor: Lima K; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Fontoura JC; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., de Souza PO; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Fazolo T; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Hilario G; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Zorzetto R; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Rodrigues Junior LC; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Coimbra LD; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Borin A; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Bispo-Dos-Santos K; Laboratory of Emerging Viruses (LEVE), Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil., Granja F; Laboratory of Emerging Viruses (LEVE), Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil.; Biodiversity Research Centre, Federal University of Roraima (UFRR), Boa Vista, Brazil., Marques RE; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Zavaglia GO; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Fernandes IR; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Varela FH; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Polese-Bonatto M; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Tonini ML; Coordenação-Geral de Vigilância das Doenças de Transmissão Respiratória de Condições Crônicas, Departamento de Doenças de Condições Crônicas e IST, Secretaria de Vigilância em Saúde - Ministério da Saúde (CGDR/DCCI/SVS/MS)., Brasília, Brazil., Ikeda do Carmo GM; Departamento de Imunizações e doenças transmissíveis, Secretaria de Vigilância em Saúde - Ministério da Saúde (DEIDT/SVS/MS), Brasília, Brazil., de Almeida WAF; Departamento de Imunizações e doenças transmissíveis, Secretaria de Vigilância em Saúde - Ministério da Saúde (DEIDT/SVS/MS), Brasília, Brazil., Borges TJ; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Nakaya HI; Computational System Biology Laboratory (CSBL), Hospital Israelita Albert Einstein, São Paulo, Brazil., Proenca-Modena JL; Laboratory of Emerging Viruses (LEVE), Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil.; Hub of Global Health (HGH), University of Campinas (Unicamp), Campinas, Brazil., Callegari-Jacques SM; Departamento de Estatística, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Scotta MC; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil.; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS, Porto Alegre, Brazil., Stein RT; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil.; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS, Porto Alegre, Brazil., Bonorino C; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil.; Department of Surgery, University of California at San Diego - UCSD, La Jolla, CA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Nov 02; Vol. 13, pp. 1033364. Date of Electronic Publication: 2022 Nov 02 (Print Publication: 2022).