Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension.

Autor: Ranasinghe ADCU; Harper Cancer Research Institute (A.D.C.U.R., V.A.P., F.J.C., M.A.S.).; Department of Chemistry and Biochemistry, University of Notre Dame (A.D.C.U.R., A.K., V.A.P., F.J.C., M.A.S.)., Holohan M; Departments of Pediatrics and Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, South Bend, IN (M.H., M.G., M.A.S.)., Borger KM; Department of Biology, University of Notre Dame (K.M.B., R.D.K.)., Donahue DL; W. M. Keck Center for Transgene Research, University of Notre Dame (D.L.D., V.A.P., F.J.C.)., Kuc RD; Department of Biology, University of Notre Dame (K.M.B., R.D.K.)., Gerig M; Departments of Pediatrics and Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, South Bend, IN (M.H., M.G., M.A.S.)., Kim A; Department of Chemistry and Biochemistry, University of Notre Dame (A.D.C.U.R., A.K., V.A.P., F.J.C., M.A.S.)., Ploplis VA; Harper Cancer Research Institute (A.D.C.U.R., V.A.P., F.J.C., M.A.S.).; Department of Biology, University of Notre Dame (K.M.B., R.D.K.).; W. M. Keck Center for Transgene Research, University of Notre Dame (D.L.D., V.A.P., F.J.C.)., Castellino FJ; Harper Cancer Research Institute (A.D.C.U.R., V.A.P., F.J.C., M.A.S.).; Department of Chemistry and Biochemistry, University of Notre Dame (A.D.C.U.R., A.K., V.A.P., F.J.C., M.A.S.).; W. M. Keck Center for Transgene Research, University of Notre Dame (D.L.D., V.A.P., F.J.C.)., Schwarz MA; Harper Cancer Research Institute (A.D.C.U.R., V.A.P., F.J.C., M.A.S.).; Department of Chemistry and Biochemistry, University of Notre Dame (A.D.C.U.R., A.K., V.A.P., F.J.C., M.A.S.).; Departments of Pediatrics and Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, South Bend, IN (M.H., M.G., M.A.S.).

Publikováno v: Circulation research [Circ Res] 2023 Sep 29; Vol. 133 (8), pp. 704-719. Date of Electronic Publication: 2023 Sep 12.