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Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

Autor: Chatterjee S; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA., Luthra P; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia 30303, USA., Esaulova E; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Computer Technologies Department, ITMO University, Saint Petersburg 197101, Russia., Agapov E; Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA., Yen BC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Borek DM; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Texas 75390, USA., Edwards MR; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA., Mittal A; Department of Biomedical Engineering, Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA., Jordan DS; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA., Ramanan P; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA., Moore ML; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA., Pappu RV; Department of Biomedical Engineering, Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA., Holtzman MJ; Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA., Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA., Basler CF; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia 30303, USA., Amarasinghe GK; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA., Leung DW; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Publikováno v: Nature microbiology [Nat Microbiol] 2017 Jun 30; Vol. 2, pp. 17101. Date of Electronic Publication: 2017 Jun 30.

Crystal structure of the human sterol transporter ABCG5/ABCG8.

Autor: Lee JY; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA., Kinch LN; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Borek DM; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Wang J; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA., Wang J; Cecil &Ida Green Center for Molecular, Computational and Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Urbatsch IL; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA., Xie XS; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA., Grishin NV; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Cohen JC; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA., Otwinowski Z; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Hobbs HH; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Rosenbaum DM; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Publikováno v: Nature [Nature] 2016 May 26; Vol. 533 (7604), pp. 561-4. Date of Electronic Publication: 2016 May 04.

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.

Autor: Brown CS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA; Biochemistry Undergraduate Program, Iowa State University, Ames, IA 50011, USA., Lee MS; Simulation Sciences Branch, US Army Research Laboratory, Aberdeen, MD 21005, USA; Department of Cell Biology and Biochemistry, USAMRIID, 1425 Porter St., Fort Detrick, MD 21702, USA., Leung DW; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Wang T; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Xu W; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Luthra P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Anantpadma M; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Shabman RS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Melito LM; Department of Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA., MacMillan KS; Department of Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA., Borek DM; Department of Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Department of Biophysics, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, IL, USA., Otwinowski Z; Department of Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Department of Biophysics, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, IL, USA., Ramanan P; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Biochemistry Graduate Program, Iowa State University, Ames, IA 50011, USA., Stubbs AJ; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA; Biochemistry Undergraduate Program, Iowa State University, Ames, IA 50011, USA., Peterson DS; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA; Biochemistry Undergraduate Program, Iowa State University, Ames, IA 50011, USA., Binning JM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Biochemistry Graduate Program, Iowa State University, Ames, IA 50011, USA., Tonelli M; National Magnetic Resonance Facility at Madison, University of Wisconsin, Madison, 433 Babcock Drive, Madison, WI 53706, USA., Olson MA; Department of Cell Biology and Biochemistry, USAMRIID, 1425 Porter St., Fort Detrick, MD 21702, USA., Davey RA; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Ready JM; Department of Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA., Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Amarasinghe GK; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: gamarasinghe@path.wustl.edu.

Publikováno v: Journal of molecular biology [J Mol Biol] 2014 May 15; Vol. 426 (10), pp. 2045-58. Date of Electronic Publication: 2014 Feb 01.

Structure of the human cohesin inhibitor Wapl.

Autor: Ouyang Z; Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jul 09; Vol. 110 (28), pp. 11355-60. Date of Electronic Publication: 2013 Jun 17.