Transcriptional Targets of TWIST1 in Human Mesenchymal Stem/Stromal Cells Mechanistically Link Stem/Progenitor and Paracrine Functions.

Autor: Haga CL; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Department of Molecular Medicine, Jupiter, FL, USA., Booker CN; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Department of Molecular Medicine, Jupiter, FL, USA., Carvalho A; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Department of Molecular Medicine, Jupiter, FL, USA., Boregowda SV; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Department of Molecular Medicine, Jupiter, FL, USA., Phinney DG; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Department of Molecular Medicine, Jupiter, FL, USA.

Publikováno v: Stem cells (Dayton, Ohio) [Stem Cells] 2023 Dec 14; Vol. 41 (12), pp. 1185-1200.

Novel role for alpha-2-macroglobulin (A2M) as a disease modifying protein in senile osteoporosis.

Autor: Boregowda SV; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, United States., Haga CL; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, United States., Supper VM; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, United States., Booker CN; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, United States., Phinney DG; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, United States.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Oct 30; Vol. 11, pp. 1294438. Date of Electronic Publication: 2023 Oct 30 (Print Publication: 2023).

Mesenchymal stem/stromal cells from a transplanted, asymptomatic patient with Fanconi anemia exhibit an aging-like phenotype and dysregulated expression of genes implicated in hematopoiesis and myelodysplasia.

Autor: Haga CL; Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA., Boregowda SV; Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA., Booker CN; Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA., Krishnappa V; Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA., Strivelli J; Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA., Cappelli E; Hematology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Phinney DG; Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA. Electronic address: dphinney@ufl.edu.

Publikováno v: Cytotherapy [Cytotherapy] 2023 Apr; Vol. 25 (4), pp. 362-368. Date of Electronic Publication: 2022 Dec 05.

Author Correction: Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts.

Autor: Booker CN; Department of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, 33458, USA., Haga CL; Department of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, 33458, USA., Boregowda SV; Department of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, 33458, USA., Strivelli J; Department of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, 33458, USA., Phinney DG; Department of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, 33458, USA. dphinney@scripps.edu.

Publikováno v: NPJ microgravity [NPJ Microgravity] 2021 Dec 15; Vol. 7 (1), pp. 54. Date of Electronic Publication: 2021 Dec 15.

Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging.

Autor: Dorronsoro A; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA., Santiago FE; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.; Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Grassi D; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA., Zhang T; Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Lai RC; Institute of Medical Biology, ASTAR, Singapore, Singapore., McGowan SJ; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.; Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Angelini L; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.; Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Lavasani M; The Shirley Ryan AbilityLab, Chicago, Illinois, USA., Corbo L; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA., Lu A; The Steadman Philippon Research Institute, Vail, Colorado, USA., Brooks RW; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA., Garcia-Contreras M; Diabetes Research Institute, University of Miami, Miami, Florida, USA., Stolz DB; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylveniya, USA., Amelio A; Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.; Department of Bioinformatics, Scripps Research, Jupiter, Florida, USA., Boregowda SV; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA., Fallahi M; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.; Department of Bioinformatics, Scripps Research, Jupiter, Florida, USA., Reich A; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.; Department of Bioinformatics, Scripps Research, Jupiter, Florida, USA., Ricordi C; Diabetes Research Institute, University of Miami, Miami, Florida, USA., Phinney DG; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA., Huard J; The Steadman Philippon Research Institute, Vail, Colorado, USA., Lim SK; Institute of Medical Biology, ASTAR, Singapore, Singapore., Niedernhofer LJ; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.; Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Robbins PD; Center on Aging and Departments of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.; Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

Publikováno v: Aging cell [Aging Cell] 2021 Apr; Vol. 20 (4), pp. e13337. Date of Electronic Publication: 2021 Mar 16.