Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition.

Autor: Nguyen MTH; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States.; Department of Life Science, Vietnam Academy of Science and Technology, University of Science and Technology of Hanoi, Hanoi, Vietnam., Imanishi M; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Li S; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Chau K; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Banerjee P; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Velatooru LR; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Ko KA; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Samanthapudi VSK; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Gi YJ; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Lee LL; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Abe RJ; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., McBeath E; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Deswal A; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Lin SH; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Palaskas NL; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Dantzer R; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Fujiwara K; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Borchrdt MK; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Turcios EB; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Olmsted-Davis EA; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Kotla S; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Cooke JP; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Wang G; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States., Abe JI; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Le NT; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2023 Aug 30; Vol. 10, pp. 1187490. Date of Electronic Publication: 2023 Aug 30 (Print Publication: 2023).