Výsledky vyhledávání - "Booyeon J, Han"

Akademický článek

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer

Autor: Jian Ye, Brian A Belt, Booyeon J Han, David C Linehan, Shuyang S Qin, Bradley N Mills, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)

Background Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death, which leads to the release of tumor antigen and damage-associated molecula

Externí odkaz: https://doaj.org/article/54b3ed967a784f7b9badf62aea058989

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Akademický článek

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment

Autor: Bradley N. Mills, Kelli A. Connolly, Jian Ye, Joseph D. Murphy, Taylor P. Uccello, Booyeon J. Han, Tony Zhao, Michael G. Drage, Aditi Murthy, Haoming Qiu, Ankit Patel, Nathania M. Figueroa, Carl J. Johnston, Peter A. Prieto, Nejat K. Egilmez, Brian A. Belt, Edith M. Lord, David C. Linehan, Scott A. Gerber

Publikováno v: Cell Reports, Vol 29, Iss 2, Pp 406-421.e5 (2019)

Summary: Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuv

Externí odkaz: https://doaj.org/article/4e46e83b18694648a2d984f0afc1f88a

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Data from Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer

Autor: Scott A. Gerber, David C. Linehan, Brian A. Belt, Edith M. Lord, Carl J. Johnston, Ankit P. Patel, Joseph D. Murphy, Booyeon J. Han, Tony Zhao, Bradley N. Mills, Jian Ye

Pancreatic ductal adenocarcinoma (PDAC) continues to have a dismal prognosis, in part, due to ineffective treatment strategies. The efficacy of some chemotherapies and especially radiotherapy is mediated partially by the immune system. Therefore, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834304e1f79187791daf99469dd0ac1c
https://doi.org/10.1158/2326-6066.c.6549813

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Abstract 1605: 'Reverse abscopal effect': Immunologically cold tumors alter systemic immunity and confer PD-1 resistance to immunologically hot tumors in synchronous melanoma

Autor: Shuyang S. Qin, Booyeon J. Han, Alexander C. Chacon, Alexa D. Melucci, Alyssa R. Williams, Rachel Jewell, Minsoo Kim, David C. Linehan, Scott A. Gerber, Peter A. Prieto

Publikováno v: Cancer Research. 82:1605-1605

PD-1 (programmed cell death protein-1) blockade, an immunotherapy that re-stimulates antitumor CD8 T cell response, has revolutionized the treatment of metastatic melanoma. However, the majority of melanoma patients eventually acquire therapy resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74f8ed18b46d86a9683e176060e9e032
https://doi.org/10.1158/1538-7445.am2022-1605

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Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma

Autor: Joseph D Murphy, David C. Linehan, Shuyang Qin, Bradley N. Mills, Jian Ye, Brian A. Belt, Nejat K. Egilmez, Taylor P Uccello, Edith M. Lord, Booyeon J. Han, Scott A. Gerber, Peter A. Prieto, Jesse Garrett-Larsen

Publikováno v: Immunol Invest

INTRODUCTION: The tumor-draining lymph node (TDLN) plays a role in tumor immunity. Intratumorally administered microspheres (MS) that encapsulate immunomodulatory agents have emerged as a treatment strategy capable of causing profound changes in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aab2770bc08f2515474ae3fc90ef47

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Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer

Autor: Jian Ye, Bradley N. Mills, Ankit Patel, Edith M. Lord, David C. Linehan, Scott A. Gerber, Brian A. Belt, Tony Zhao, Carl J. Johnston, Joseph D Murphy, Booyeon J. Han

Publikováno v: Cancer Immunol Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056bfa8bfaafb51101bfbb4ad57b9535
https://pubmed.ncbi.nlm.nih.gov/31719057

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Targeting both tumour-associated CXCR2

Autor: Timothy M, Nywening, Brian A, Belt, Darren R, Cullinan, Roheena Z, Panni, Booyeon J, Han, Dominic E, Sanford, Ryan C, Jacobs, Jian, Ye, Ankit A, Patel, William E, Gillanders, Ryan C, Fields, David G, DeNardo, William G, Hawkins, Peter, Goedegebuure, David C, Linehan

Publikováno v: Gut. 67(6)

Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive tumour microenvironment (TME). Targeting tumour-associated CXCR2Blood, bone marrow and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e01854102c8866ce7411882328cb890b
https://pubmed.ncbi.nlm.nih.gov/29217750

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