Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment

Autor: Michael Fehlings, Suchit Jhunjhunwala, Marcin Kowanetz, William E. O’Gorman, Priti S. Hegde, Hermi Sumatoh, Boon Heng Lee, Alessandra Nardin, Etienne Becht, Susan Flynn, Marcus Ballinger, Evan W. Newell, Mahesh Yadav

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Background There is strong evidence that immunotherapy-mediated tumor rejection can be driven by tumor-specific CD8+ T cells reinvigorated to recognize neoantigens derived from tumor somatic mutations. Thus, the frequencies or characteristic

Externí odkaz: https://doaj.org/article/521c2f3238b047f6a7391405547e902b

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

Autor: Annemarie Voorberg-van der Wel, Guglielmo Roma, Devendra Kumar Gupta, Sven Schuierer, Florian Nigsch, Walter Carbone, Anne-Marie Zeeman, Boon Heng Lee, Sam O Hofman, Bart W Faber, Judith Knehr, Erica Pasini, Bernd Kinzel, Pablo Bifani, Ghislain M C Bonamy, Tewis Bouwmeester, Clemens H M Kocken, Thierry Tidiane Diagana

Publikováno v: eLife, Vol 6 (2017)

Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of the parasite is poorly understood which hinders drug discovery. We report a com

Externí odkaz: https://doaj.org/article/fe01f6ed27ac49e38c3c509c4167af68

Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung

Autor: Alessandra Nardin, Rajhmun Madansein, Amanda Ardain, Khadija Khan, Kaylesh J. Dullabh, Alveera Singh, Taryn Naidoo, Alessandro Sette, Farina Karim, Samuel M. Behar, Alasdair Leslie, Paul T. Elkington, Liku B. Tezera, Duran Ramsuran, Michael G. Fehlings, Abigail Ngoepe, Paul Ogongo, Cecilia S. Lindestam Arlehamn, Henrik N. Kløverpris, Shepherd Nhamoyebonde, Adrie J. C. Steyn, Boon Heng Lee

Publikováno v: The Journal of Clinical Investigation
Ogongo, P, Tezera, L B, Ardain, A, Nhamoyebonde, S, Ramsuran, D, Singh, A, Ng’oepe, A, Karim, F, Naidoo, T, Khan, K, Dullabh, K J, Fehlings, M, Lee, B H, Nardin, A, Lindestam Arlehamn, C S, Sette, A, Behar, S M, Steyn, A J C, Madansein, R, Kløverpris, H N, Elkington, P T & Leslie, A 2021, ' Tissue-resident-like CD4 + T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung ', Journal of Clinical Investigation, vol. 131, no. 10, e142014 . https://doi.org/10.1172/JCI142014

T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood cells. Mounting evidence, however, indicates that tissue-resident memory T cells (Trms) are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c54f1e337bceef35ac1e1654d343094
http://europepmc.org/articles/PMC8121523

Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses.

Autor: Mai Ping Tan, Patricia Sequeira, Wen Wei Lin, Wai Yee Phong, Penelope Cliff, Seow Hwee Ng, Boon Heng Lee, Luis Camacho, Dirk Schnappinger, Sabine Ehrt, Thomas Dick, Kevin Pethe, Sylvie Alonso

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13356 (2010)

There are strong evidences that Mycobacterium tuberculosis survives in a non-replicating state in the absence of oxygen in closed lesions and granuloma in vivo. In addition, M. tuberculosis is acid-resistant, allowing mycobacteria to survive in acidi

Externí odkaz: https://doaj.org/article/cdb947bf7d294f19b849e7705ac8e9c1

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

Autor: Clemens H. M. Kocken, Judith Knehr, Devendra Kumar Gupta, Ghislain M. C. Bonamy, Bart W. Faber, Boon Heng Lee, Sam O. Hofman, Erica M. Pasini, Sven Schuierer, Florian Nigsch, Tewis Bouwmeester, Walter Carbone, Annemarie Voorberg-van der Wel, Thierry T. Diagana, Guglielmo Roma, Bernd Kinzel, Anne-Marie Zeeman, Pablo Bifani

Publikováno v: eLife, Vol 6 (2017)

Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of the parasite is poorly understood which hinders drug discovery. We report a com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d131bbca6690c622bfa8ecdf24ce7c77
https://elifesciences.org/articles/29605