Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Boon Hooi Tan"'
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
Since the discovery of its role in vitamin D metabolism, significant progress has been made in the understanding of gene organisation, protein structure, catalytic function, and genetic polymorphism of cytochrome P450 2R1 (CYP2R1). Located on chromos
Externí odkaz:
https://doaj.org/article/b47450a71af4493e94b255595e2061a9
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 20, Iss 1 (2018)
In vitro and in silico models of drug metabolism are utilized regularly in the drug research and development as tools for assessing pharmacokinetic variability and drug-drug interaction risk. The use of in vitro and in silico predictive approaches of
Externí odkaz:
https://doaj.org/article/8a824964e2b84c0d9dbb8d60f96cdde3
Autor:
Boon Hooi Tan, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Iekhsan Othman, Beow Chin Yiap, Chin Eng Ong
Five natural anti-arthritic compounds, diacerein, rhein, glucosamines (glucosamine 3-sulfate, G3S, and glucosamine 6-sulfate, G6S), and chondroitin disaccharide Δdi-4S (C4S) were docked individually to the defined binding site in CYP2C9 based on pub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7794d816bdd26f79b630419b594cdcdc
https://doi.org/10.21203/rs.3.rs-2354931/v1
https://doi.org/10.21203/rs.3.rs-2354931/v1
Publikováno v:
Current drug metabolism. 23(5)
Abstracts: Cancer is a leading cause of mortality globally. Cytochrome P450 (CYP) enzymes play a pivotal role in the biotransformation of both endogenous and exogenous compounds. Various lines of evidence from epidemiological, animal, and clinical st
Publikováno v:
Drug Metabolism and Personalized Therapy.
Objectives Glucosamine, chondroitin and diacerein are natural compounds commonly used in treating osteoarthritis. Their concomitant intake may trigger drug–natural product interactions. Cytochrome P450 (CYP) has been implicated in such interactions
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
Since the discovery of its role in vitamin D metabolism, significant progress has been made in the understanding of gene organisation, protein structure, catalytic function, and genetic polymorphism of cytochrome P450 2R1 (CYP2R1). Located on chromos
Autor:
Iekhsan Othman, Nafees Ahemad, Beow Chin Yiap, Boon Hooi Tan, Yan Pan, Chin Eng Ong, Uma Devi Palanisamy
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:205-217
Many dietary supplements are promoted to patients with osteoarthritis (OA) including the three naturally derived compounds, glucosamine, chondroitin and diacerein. Despite their wide spread use, research on interaction of these antiarthritic compound
Publikováno v:
Pharmaceutical Biocatalysis ISBN: 9780429295034
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa3cb011f420c9b2a0407353e0cb828
https://doi.org/10.1201/9780429295034-15
https://doi.org/10.1201/9780429295034-15
Publikováno v:
Clinical and experimental pharmacologyphysiology. 45(10)
Over the past 2 decades, knowledge of the role and clinical value of pharmacogenetic markers has expanded so that individualized pre-emptive therapy based on genetic background of patients could be within reach for clinical implementation. This is ev
Autor:
Boon Hooi, Tan, Nafees, Ahemad, Yan, Pan, Uma Devi, Palanisamy, Iekhsan, Othman, Beow Chin, Yiap, Chin Eng, Ong
Publikováno v:
Biopharmaceuticsdrug disposition. 39(4)
Many dietary supplements are promoted to patients with osteoarthritis (OA) including the three naturally derived compounds, glucosamine, chondroitin and diacerein. Despite their wide spread use, research on interaction of these antiarthritic compound