Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Boon C Goh"'
Autor:
Lawrence Soon-U Lee, Kok-Yong Seng, Ling-Zhi Wang, Wei-Peng Yong, Kim-Hor Hee, Thomas I Soh, Andrea Wong, Pei F Cheong, Richie Soong, Nur S Sapari, Ross Soo, Lu Fan, Soo-Chin Lee, Boon C Goh
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147681 (2016)
BACKGROUND:Irinotecan toxicity correlates with UGT1A1 activity. We explored whether phenotyping UGT1A1 using a probe approach works better than current genotyping methods. METHODS:Twenty-four Asian cancer patients received irinotecan as part of the F
Externí odkaz:
https://doaj.org/article/6295a6cdf52940d7a4543df1021b5144
Autor:
Daniel Z. Hong, Thaned C. C. Ong, Dhayan P. Timbadia, Hui T. A. Tan, Eunice D. Kwa, Wan Q. Chong, Boon C. Goh, Woei S. Loh, Kwok S. Loh, Ene C. Tan, Joshua K. Tay
Publikováno v:
Otolaryngology–Head and Neck Surgery. 168:1324-1337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bee7cc9153724a4273ba819527a257e
https://doi.org/10.1002/ohn.222
https://doi.org/10.1002/ohn.222
Autor:
Alan P. Kumar, Lina H.K. Lim, Gautam Sethi, Peter E. Lobie, Louis Gaboury, Joo I. Park, Boon C. Goh, Henry Yang, Han M. Shen, Frank Arfuso, Sung W. Shin, Tuan Z. Tan, Muthu K. Shanmugam, Ramar P. Samy, Einas Yousef, Pei F. Koh, Ji E. Kim, Suruchi Arora, Madhu M. Kanchi, Shreya Kar, Yi Yuan, Luxi Chen
Metastatic breast cancer is still incurable so far; new specifically targeted and more effective therapies for triple-negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data have established that basal and claudin-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a0c0e006c3abbabd69d14315bda93e
https://doi.org/10.1158/1535-7163.c.6539263.v1
https://doi.org/10.1158/1535-7163.c.6539263.v1
Autor:
Alan P. Kumar, Lina H.K. Lim, Gautam Sethi, Peter E. Lobie, Louis Gaboury, Joo I. Park, Boon C. Goh, Henry Yang, Han M. Shen, Frank Arfuso, Sung W. Shin, Tuan Z. Tan, Muthu K. Shanmugam, Ramar P. Samy, Einas Yousef, Pei F. Koh, Ji E. Kim, Suruchi Arora, Madhu M. Kanchi, Shreya Kar, Yi Yuan, Luxi Chen
Supplementary Figure 1: High ANXA1 and PPARγ expression levels positively correlates with the invasive, high-grade phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a52bb0d216b583547635ad48b7918
https://doi.org/10.1158/1535-7163.22509319
https://doi.org/10.1158/1535-7163.22509319
Autor:
Alan P. Kumar, Lina H.K. Lim, Gautam Sethi, Peter E. Lobie, Louis Gaboury, Joo I. Park, Boon C. Goh, Henry Yang, Han M. Shen, Frank Arfuso, Sung W. Shin, Tuan Z. Tan, Muthu K. Shanmugam, Ramar P. Samy, Einas Yousef, Pei F. Koh, Ji E. Kim, Suruchi Arora, Madhu M. Kanchi, Shreya Kar, Yi Yuan, Luxi Chen
Supplementary Figure 2: ANXA1 expressing TNBC cell lines display greater sensitivity to PPARγ ligands compared to ANXA1 depleted cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48392110051076c68f80b12a3c9855ed
https://doi.org/10.1158/1535-7163.22509316
https://doi.org/10.1158/1535-7163.22509316
Autor:
Alan P. Kumar, Lina H.K. Lim, Gautam Sethi, Peter E. Lobie, Louis Gaboury, Joo I. Park, Boon C. Goh, Henry Yang, Han M. Shen, Frank Arfuso, Sung W. Shin, Tuan Z. Tan, Muthu K. Shanmugam, Ramar P. Samy, Einas Yousef, Pei F. Koh, Ji E. Kim, Suruchi Arora, Madhu M. Kanchi, Shreya Kar, Yi Yuan, Luxi Chen
Supplementary methods and supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6963a538aeeeffe32e7e217be5f31
https://doi.org/10.1158/1535-7163.22509322.v1
https://doi.org/10.1158/1535-7163.22509322.v1
Autor:
Alan P. Kumar, Lina H.K. Lim, Gautam Sethi, Peter E. Lobie, Louis Gaboury, Joo I. Park, Boon C. Goh, Henry Yang, Han M. Shen, Frank Arfuso, Sung W. Shin, Tuan Z. Tan, Muthu K. Shanmugam, Ramar P. Samy, Einas Yousef, Pei F. Koh, Ji E. Kim, Suruchi Arora, Madhu M. Kanchi, Shreya Kar, Yi Yuan, Luxi Chen
Supplementary Figure 3: PPARγ induced expression of ANXA1 and cell death is abrogated in TNBC cells with pre-incubation of a PPARγ-specific antagonist or use of a dominant negative derivative of PPARγ.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0f8a276b53f71a91851a1a8a4f6ab9
https://doi.org/10.1158/1535-7163.22509313.v1
https://doi.org/10.1158/1535-7163.22509313.v1
Autor:
Alan P. Kumar, Lina H.K. Lim, Gautam Sethi, Peter E. Lobie, Louis Gaboury, Joo I. Park, Boon C. Goh, Henry Yang, Han M. Shen, Frank Arfuso, Sung W. Shin, Tuan Z. Tan, Muthu K. Shanmugam, Ramar P. Samy, Einas Yousef, Pei F. Koh, Ji E. Kim, Suruchi Arora, Madhu M. Kanchi, Shreya Kar, Yi Yuan, Luxi Chen
Supplementary Figure 4: PPARγ ligand-induced changes in expression of RIP1 and NEMO and therefore NFκB activity are receptor dependent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d9325507dd54cc45444196a0bdeaf
https://doi.org/10.1158/1535-7163.22509310
https://doi.org/10.1158/1535-7163.22509310
Autor:
Mei S, Ong, Wanpei, Cai, Yi, Yuan, Hin C, Leong, Tuan Z, Tan, Asad, Mohammad, Ming L, You, Frank, Arfuso, Boon C, Goh, Sudha, Warrier, Gautam, Sethi, Nicholas S, Tolwinski, Peter E, Lobie, Celestial T, Yap, Shing C, Hooi, Ruby Y, Huang, Alan P, Kumar
Publikováno v:
British journal of pharmacology. 174(24)
Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology, as non-coding RNAs and related processes have been found to be important in regulating gene expression. MicroRNAs and long non-coding RNAs (l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::727f07ab918afd6e74829097d3bf452e
https://pubmed.ncbi.nlm.nih.gov/28736855
https://pubmed.ncbi.nlm.nih.gov/28736855
Autor:
Su Pin Choo, Quan Sing Ng, Wallace Jian Jun Chen, Chee Kian Tham, Wei-Peng Yong, Ling Zhi Wang, Tong San Koh, Boon C. Goh, Choon Hua Thng, Hung The Huynh, Ying Kiat Zee, Li shan Low, Han Chong Toh
Publikováno v:
Journal of Clinical Oncology. 30:4100-4100
4100^ Background: Preclinical studies have shown that pharmacological inhibition of the MEK/ERK pathway by AZD6244 enhanced the anti-tumor effect of sorafenib in both orthotopic and ectopic models of HCC. We conducted this study to determine tolerabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9779b911f42a2dc808e5d2d735fc2788
https://doi.org/10.1200/jco.2012.30.15_suppl.4100
https://doi.org/10.1200/jco.2012.30.15_suppl.4100