Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Boon‐Cher Goh"'
Autor:
Le Cheng, Limin Zhang, Xiaoxiao Wang, Yufei Wang, Jiahui Yu, Mengnan Li, Zhaowu Ma, Paul Chi-Lui Ho, Xiaoguang Chen, Lingzhi Wang, Gautam Sethi, Boon-Cher Goh
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107419- (2024)
Hepatocellular carcinoma (HCC) stands as the sixth most prevalent cancer and the third leading cause of cancer mortality globally. Despite surgical resection being the preferred approach for early-stage HCC, most patients are diagnosed at intermediat
Externí odkaz:
https://doaj.org/article/70f31f83321e445c8d89a965930617ee
Autor:
Harue Mizokami, Atsushi Okabe, Ruchi Choudhary, Masato Mima, Kenta Saeda, Masaki Fukuyo, Bahityar Rahmutulla, Motoaki Seki, Boon-Cher Goh, Satoru Kondo, Hirotomo Dochi, Makiko Moriyama-Kita, Kiyoshi Misawa, Toyoyuki Hanazawa, Patrick Tan, Tomokazu Yoshizaki, Melissa Jane Fullwood, Atsushi Kaneda
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105057- (2024)
Summary: Background: Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its
Externí odkaz:
https://doaj.org/article/0d406c389ac048dea04ff8c3811564af
Autor:
Darren Wan-Teck Lim, Hsiang-Fong Kao, Lisda Suteja, Constance H. Li, Hong Sheng Quah, Daniel Shao-Weng Tan, Sze-Huey Tan, Eng-Huat Tan, Wan-Ling Tan, Justina Nadia Lee, Felicia Yu-Ting Wee, Amit Jain, Boon-Cher Goh, Melvin L. K. Chua, Bin-Chi Liao, Quan Sing Ng, Ruey-Long Hong, Mei-Kim Ang, Joe Poh-Sheng Yeong, N. Gopalakrishna Iyer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Single-agent checkpoint inhibitor (CPI) activity in Epstein-Barr Virus (EBV) related nasopharyngeal carcinoma (NPC) is limited. Dual CPI shows increased activity in solid cancers. In this single-arm phase II trial (NCT03097939), 40 patients
Externí odkaz:
https://doaj.org/article/9dac3f0d6a524296a18f65ed171dcbf2
Autor:
Malia Alexandra Foo, Mingliang You, Shing Leng Chan, Gautam Sethi, Glenn K. Bonney, Wei-Peng Yong, Edward Kai-Hua Chow, Eliza Li Shan Fong, Lingzhi Wang, Boon-Cher Goh
Publikováno v:
Biomarker Research, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics and Artificial Intelligence (AI) have contributed greatly to preclinical drug development and precision medicine. The intrinsic ability to maintain genetic and ph
Externí odkaz:
https://doaj.org/article/f0a8fa04d01c460ea1d92472ba0a469d
Autor:
Zhaowu Ma, Clariis Yi-Ning Woon, Chen-Guang Liu, Jun-Ting Cheng, Mingliang You, Gautam Sethi, Andrea Li-Ann Wong, Paul Chi-Lui Ho, Daping Zhang, Peishi Ong, Lingzhi Wang, Boon-Cher Goh
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cancer has become a global health problem, accounting for one out of six deaths. Despite the recent advances in cancer therapy, there is still an ever-growing need for readily accessible new therapies. The process of drug discovery and development is
Externí odkaz:
https://doaj.org/article/134f4c87496546d8ab087ad844cf8e3e
Autor:
Sneha Rajiv Jain, Wilson Sim, Cheng Han Ng, Yip Han Chin, Wen Hui Lim, Nicholas L. Syn, Nur Haidah Bte Ahmad Kamal, Mehek Gupta, Valerie Heong, Xiao Wen Lee, Nur Sabrina Sapari, Xue Qing Koh, Zul Fazreen Adam Isa, Lucius Ho, Caitlin O’Hara, Arvindh Ulagapan, Shi Yu Gu, Kashyap Shroff, Rei Chern Weng, Joey S. Y. Lim, Diana Lim, Brendan Pang, Lai Kuan Ng, Andrea Wong, Ross Andrew Soo, Wei Peng Yong, Cheng Ean Chee, Soo-Chin Lee, Boon-Cher Goh, Richie Soong, David S.P. Tan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
PurposePrecision oncology, such as next generation sequencing (NGS) molecular analysis and bioinformatics are used to guide targeted therapies. The laboratory turnaround time (TAT) is a key performance indicator of laboratory performance. This study
Externí odkaz:
https://doaj.org/article/480d74809a6444808db8f8d1fd0737bc
Autor:
Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai, Boon-Cher Goh
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-10 (2018)
Abstract Background Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. Methods An open-label, non-inf
Externí odkaz:
https://doaj.org/article/087728fcda5943cda118924e863a9094
Autor:
Chee-Seng Tan, Nesaretnam Barr Kumarakulasinghe, Yi-Qing Huang, Yvonne Li En Ang, Joan Rou-En Choo, Boon-Cher Goh, Ross A. Soo
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-14 (2018)
Abstract Acquired T790 M mutation is the commonest cause of resistance for advanced non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) mutant patients who had progressed after first line EGFR TKI (tyrosine kinase inhibitor). S
Externí odkaz:
https://doaj.org/article/84a238cb5bb54ebe9e8039ed5b019262
Autor:
Matilda Lee, Jayshree L. Hirpara, Jie-Qing Eu, Gautam Sethi, Lingzhi Wang, Boon-Cher Goh, Andrea L. Wong
Publikováno v:
Redox Biology, Vol 25, Iss , Pp - (2019)
Drug resistance invariably limits the response of oncogene-addicted cancer cells to targeted therapy. The upregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a mechanism of drug resistance in a range of o
Externí odkaz:
https://doaj.org/article/b330188b745046ad9a8a87415c4adf74
Autor:
Win Lwin Thuya, Janique Michelle Peyper, Tan Ti Myen, Nur Diana Anuar, Arif Anwar, Ranga Gudimella, Nurul Huda Rutt, Nurul Shielawati Mohamed Rosli, Noorul Hidayah Badri, Teh Norleila Abdul Rahman, Raja Nurashirin, Gautam Sethi, John Kit Chung Tam, Andrea Li-Ann Wong, Ross Soo, Jonathan M. Blackburn, Lingzhi Wang, Boon Cher Goh
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/74ef3dedaf8c41c5bf5fa6cdfbdd40a4